Collagen supplements could boost standard gum disease therapy

NCT ID NCT07683741

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial investigates whether taking a collagen supplement alongside standard non-surgical gum treatment (deep cleaning) can improve outcomes for people with advanced periodontitis (stage 3-4). Half of the 52 participants will receive the supplement, while the other half gets a placebo. Researchers will measure changes in gum pocket depth and tissue attachment, as well as markers of inflammation, over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hydrolyzed collagen peptides
What this could lead to
If it works, this could point toward a simple dietary supplement that improves gum health and reduces the need for more invasive procedures.
What could go wrong
This is a small, early-stage study with only 52 participants, so results may not apply broadly. The supplement may show no added benefit over standard treatment alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Feb 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 - 60 age * stage 3-4 periodontitis Exclusion Criteria: * Patients who smoke more than 10 cigarettes a day * Patients using immunosuppressive, oral contraceptive, bisphosphonate drugs * Patients who are during pregnancy or lactation * Having undergone periodontal treatment in the last 6 months, having used antibiotic anti-inflammatory medication in the last 4 weeks * The presence of any autoimmune disease, osteoporotic disease or cancer disease * Patients with renal and hepatic insufficiency * Patients with thyroid dysfunction * The presence of active infectious diseases(acute hepatitis, tuberculosis, AIDS) * Chronic drug use affecting periodontal tissues(cyclosporine A, Phenytoin) * Intake of antioxidant supplements

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Recep Tayyip Erdogan University

    Rize, Rize Province, 53000, Turkey (Türkiye)

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