Collagen supplements could boost standard gum disease therapy
NCT ID NCT07683741
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This trial investigates whether taking a collagen supplement alongside standard non-surgical gum treatment (deep cleaning) can improve outcomes for people with advanced periodontitis (stage 3-4). Half of the 52 participants will receive the supplement, while the other half gets a placebo. Researchers will measure changes in gum pocket depth and tissue attachment, as well as markers of inflammation, over six months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hydrolyzed collagen peptides
- What this could lead to
- If it works, this could point toward a simple dietary supplement that improves gum health and reduces the need for more invasive procedures.
- What could go wrong
- This is a small, early-stage study with only 52 participants, so results may not apply broadly. The supplement may show no added benefit over standard treatment alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
52 people
The number who actually took part.
- Started
-
Feb 2025
- Finished
-
May 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 60 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18 - 60 age * stage 3-4 periodontitis Exclusion Criteria: * Patients who smoke more than 10 cigarettes a day * Patients using immunosuppressive, oral contraceptive, bisphosphonate drugs * Patients who are during pregnancy or lactation * Having undergone periodontal treatment in the last 6 months, having used antibiotic anti-inflammatory medication in the last 4 weeks * The presence of any autoimmune disease, osteoporotic disease or cancer disease * Patients with renal and hepatic insufficiency * Patients with thyroid dysfunction * The presence of active infectious diseases(acute hepatitis, tuberculosis, AIDS) * Chronic drug use affecting periodontal tissues(cyclosporine A, Phenytoin) * Intake of antioxidant supplements
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Periodontitis (stage 3) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Recep Tayyip Erdogan University
Rize, Rize Province, 53000, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can laser or Air-Polishing boost gum disease treatment?
- Can a Skin-Derived graft match the gold standard for saving molars?
- Can spit reveal how smoking fuels gum disease?
- Can a gentler Deep-Clean beat standard gum therapy?
- Gel boosts gum healing after deep cleaning for advanced periodontitis — trial puts it to the test
- Timing of gum disease check-ups could change treatment success