Can a Skin-Derived graft match the gold standard for saving molars?
NCT ID NCT07770256
First seen Aug 18, 2026 · Last updated Aug 18, 2026
Summary
This trial tests two surgical techniques for repairing furcation defects—areas where bone loss has occurred between the roots of lower molars—in people with advanced periodontitis. One method uses a graft derived from donated skin (acellular dermal matrix), while the other uses a connective tissue graft taken from the patient's own palate. Both are combined with enamel matrix derivative and bone graft material. The study also checks how accurately 3D imaging (CBCT) measures these defects compared to direct measurements during surgery. The goal is to see which approach better reduces pocket depth and improves attachment levels, potentially offering a less invasive option for saving teeth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Regenerative periodontal surgery comparing Acellular Dermal Matrix (ADM) plus Enamel Matrix Derivative (EMD) and xenograft versus Autogenous Connective Tissue Graft (CTG) plus EMD and xenograft.
- What this could lead to
- If successful, this could identify a better surgical approach for repairing furcation defects, potentially improving tooth retention and reducing the need for extractions in periodontitis patients.
- What could go wrong
- This is a relatively small trial (30 surgical patients) and results may not apply broadly. Surgery carries risks like infection, graft failure, or nerve damage, and long-term benefits are not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dental Clinic, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City
RECRUITINGHo Chi Minh City, 700000, Vietnam
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