Can a Skin-Derived graft match the gold standard for saving molars?

NCT ID NCT07770256

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This trial tests two surgical techniques for repairing furcation defects—areas where bone loss has occurred between the roots of lower molars—in people with advanced periodontitis. One method uses a graft derived from donated skin (acellular dermal matrix), while the other uses a connective tissue graft taken from the patient's own palate. Both are combined with enamel matrix derivative and bone graft material. The study also checks how accurately 3D imaging (CBCT) measures these defects compared to direct measurements during surgery. The goal is to see which approach better reduces pocket depth and improves attachment levels, potentially offering a less invasive option for saving teeth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Regenerative periodontal surgery comparing Acellular Dermal Matrix (ADM) plus Enamel Matrix Derivative (EMD) and xenograft versus Autogenous Connective Tissue Graft (CTG) plus EMD and xenograft.
What this could lead to
If successful, this could identify a better surgical approach for repairing furcation defects, potentially improving tooth retention and reducing the need for extractions in periodontitis patients.
What could go wrong
This is a relatively small trial (30 surgical patients) and results may not apply broadly. Surgery carries risks like infection, graft failure, or nerve damage, and long-term benefits are not yet proven.

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Conditions

The condition(s) this trial relates to.

Furcation Defects periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Dental Clinic, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City

    RECRUITING

    Ho Chi Minh City, 700000, Vietnam

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