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Micro-needling vs. gum graft: a tiny trial tests a simpler fix for receding gums

NCT ID NCT05470660

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This pilot study tests whether micro-needling, combined with a gum-lifting procedure, can thicken receding gums as well as a standard gum graft substitute (Alloderm). Twenty-four adults with at least 3 mm of gum recession on a front tooth will receive one of the two treatments. The main goal is to see how much gum thickness increases after six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a gum-lifting procedure (coronally advanced flap) combined with either micro-needling or a donated skin graft substitute (Alloderm)
What this could lead to
If micro-needling works as well as a graft substitute, it could offer a simpler, less invasive option for treating receding gums.
What could go wrong
This is a very small pilot study with only 24 people, so results may not apply widely. Micro-needling is a new approach for gum recession and may not thicken gums as effectively as the graft.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Jul 2022

Finished

Jun 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient consulting in the outpatient clinic. * Able to tolerate the study procedures. * Patient ready to perform oral hygiene instructions. * Compliance with the maintenance program. * Provide informed consent. * Accepts the 6 months follow-up period * Mature permanent tooth. * Full-mouth plaque index (PI) and full-mouth bleeding on probing (BOP) score of ≤ 15%. * Presence of identifiable Cemento-enamel Junction. * RT1 facial recession defect of ≥3 mm. * Clinical indication and/or patient request for recession coverage Exclusion Criteria: * Medically compromised patients. * use of any drugs that might lead to gingival enlargement * Pregnant or nursing women. * Uncooperative patients. * Smokers. * Teeth with malocclusion, crowding, fillings, missing or supernumerary mandibular anterior teeth. * Cairo Recession Type 3 (RT3) recession defects. * Teeth with active orthodontic treatment. * Previous periodontal surgery.

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession Recession, gingival Thin-gingiva

Contacts and locations

Locations

  • Faculty of Dentistry - Cairo University

    Cairo, Egypt

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