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Boosting gum grafts: do blood or gel Add-Ons reduce shrinkage?

NCT ID NCT07804888

Disease control Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This trial tests whether adding injectable platelet-rich fibrin (i-PRF) or hyaluronic acid gel to standard free gingival graft surgery improves healing and reduces graft shrinkage. Adults with gum recession and insufficient keratinized tissue will be randomly assigned to one of three groups: standard surgery, surgery with i-PRF, or surgery with hyaluronic acid. Researchers will measure graft shrinkage and wound healing over a 3-month follow-up to compare the approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Injectable platelet-rich fibrin (i-PRF) and hyaluronic acid gel, each added to free gingival graft surgery
What this could lead to
If it works, adding i-PRF or hyaluronic acid to gum graft surgery could improve healing and reduce graft shrinkage, leading to better long-term outcomes for patients with gum recession.
What could go wrong
This is a small, early-stage trial with 45 participants, so results may not apply broadly. The added treatments may not significantly improve healing or shrinkage compared to standard surgery alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 18 years or older. * Systemically healthy patients with no contraindications for periodontal surgery. * Patients presenting with gingival recession and/or inadequate width of keratinized tissue requiring Free Gingival Graft (FGG) therapy. * Non-smokers. * Patients who provide written informed consent to participate in the study. Exclusion Criteria: * Patients with systemic diseases that may affect wound healing (e.g., uncontrolled diabetes mellitus, autoimmune disorders). * Pregnant or lactating individuals. * Patients with poor oral hygiene. * Current smokers or tobacco users. * Patients who have received periodontal surgery in the designated surgical area within the last 6 months.

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession Lack of keratinized tissue Mucogingival surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Health Sciences, Gülhane Faculty of Dentistry

    Ankara, Turkey (Türkiye)

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