New study tests simple ways to erase chalky white spots on teeth without drilling
NCT ID NCT07704983
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
Dental fluorosis can leave chalky white spots on front teeth, affecting appearance even when the enamel is intact. This trial compares two gentle treatments—resin infiltration and enamel microabrasion followed by a calcium-phosphate paste—for masking those spots. Researchers measure color matching and spot size from photos taken before, right after, and up to six months later. The goal is to find which approach works better and lasts longer.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- resin infiltration or enamel microabrasion plus CPP-ACP
- What this could lead to
- If successful, this could offer a simple, effective way to improve the appearance of fluorosis-related white spots on front teeth without drilling or filling.
- What could go wrong
- This is a small, short-term study (42 people, 6 months). Results may not apply to everyone, and the effects might fade over time.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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42 people
The number who actually took part.
- Started
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Jun 2023
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients presenting with fluorotic white spot lesions on permanent anterior teeth. * Shallow fluorotic white spot lesions confined to the outer enamel. * Chalky-white lesions with a clear border from adjacent sound enamel. * Lesions appearing bright on oblique visual inspection and mildly dim under diagnostic transillumination. * Clinical diagnosis of dental fluorosis based on the characteristic bilateral, symmetrical, and diffuse distribution of enamel opacities. * Willingness to participate in the study and comply with treatment and follow-up visits. Exclusion Criteria: * Deep subsurface enamel lesions. * Lesions consistent with molar-incisor hypomineralization. * Lesions with yellow or brown discoloration. * Known allergy or hypersensitivity to ICON, Opalustre, Tooth Mousse, or their components. * Inability to tolerate rubber-dam isolation. * Poor oral hygiene. * Inability or unwillingness to attend the scheduled follow-up assessments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Odonto-Stomatology, University of Medicine and Pharmacy, Hue University
Huế, 530000, Vietnam