Could probiotics ease pain after root canal? new trial investigates
NCT ID NCT07683520
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This trial tests whether taking probiotics by mouth, along with standard root canal medications, can reduce pain and improve healing in people with chronic tooth infections. Participants will receive either a probiotic capsule or a placebo for 21 days, combined with one of three root canal treatments. The study measures pain levels and markers of bone healing to see if the combination works better than standard care alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Probiotics (Lactobacillus acidophilus, Bifidobacterium animalis) and propolis or calcium hydroxide intracanal medicaments
- What this could lead to
- If successful, this could point toward a simple probiotic supplement to reduce pain and improve healing after root canal treatment for chronic tooth infections.
- What could go wrong
- This is a small, early-phase trial with only 72 participants. Results may not apply to all patients, and the effect of probiotics on dental infections is still uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Faculty of Dentistry, Ain Shams University
Cairo, Cairo Governorate, 11566, Egypt
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