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Tiny particles, big relief? Nano-Calcium hydroxide may soothe root canal pain

NCT ID NCT07057336

Symptom relief Sponsor: Cukurova University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether a nano-sized form of calcium hydroxide, placed inside the tooth after cleaning, reduces pain following root canal treatment compared to the conventional version. Adults aged 18 to 65 with a dead nerve in a single-rooted tooth and an infection at the tip of the root are eligible. Participants receive either conventional or nano-calcium hydroxide as a temporary filling, then rate their pain on a standard scale. The goal is to see if the nano version offers better pain control during recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nano-sized calcium hydroxide
What this could lead to
If it works, nano-calcium hydroxide could become a standard intracanal medicament that makes root canal recovery more comfortable.
What could go wrong
This is a small, early-stage trial, and the benefit may be modest or not clearly better than the conventional treatment. Pain after root canal varies widely among individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

May 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-65 years * Single-rooted permanent maxillary or mandibular teeth * Asymptomatic teeth with necrotic pulps confirmed by negative response to cold test * Presence of periapical radiolucency (PAI score 2-5) * No sensitivity to percussion or palpation * Patients who signed informed consent Exclusion Criteria: * Pregnancy or lactation * Systemic diseases requiring antibiotic prophylaxis (e.g., infective endocarditis, immunosuppression) * Use of antibiotics, corticosteroids, or analgesics within the past 7 days * History of chemotherapy or radiotherapy * Uncontrolled diabetes mellitus or hypertension * Chronic renal failure, hematologic disorders * Teeth with root resorption, previous endodontic treatment, or multirooted anatomy * Teeth with periodontal pockets \>4 mm or mobility * Inability to attend follow-up visits * Patients with extensive coronal destruction rendering definitive restoration unfeasible

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical periodontitis

Contacts and locations

Locations

  • Cukurova University

    Adana, Sarıçam, 01250, Turkey (Türkiye)

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