Could a Nano-Gel inside the tooth silence Post-Root-Canal pain?
NCT ID NCT07064083
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This trial tests whether placing a nano-form of the painkiller ketorolac inside the root canal can reduce pain after root canal treatment. Adults aged 18–50 with an infected tooth nerve will receive either nano-ketorolac, regular ketorolac, or a placebo gel during the procedure. Pain levels will be measured over the following week to see if the nano version offers better relief.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nano-ketorolac gel placed inside the root canal
- What this could lead to
- If effective, this could offer a simple, targeted way to ease pain after root canal treatment, reducing the need for oral painkillers.
- What could go wrong
- This is a small early-phase trial, so results may not apply broadly. The gel is placed inside the tooth, and its pain-relieving effect may be limited or no better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
-
45 people
The number who actually took part.
- Started
-
Aug 2025
- Finished
-
Feb 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 50 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 18-50 years. * Patients who are diagnosed with necrotic pulp and chronic apical periodontitis in a single-rooted tooth. * Patients who provide written informed consent. * Patients with no systemic diseases affecting pain perception or wound healing. Exclusion Criteria: * Patients with irreversible pulpitis or acute periapical abscess * Patients with a history of NSAID or opioid use within 24 hours before treatment. * Pregnant or lactating women. * Patients who require more than two-visits root canal treatment due to anatomical or pathological factors.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Collage of Oral and Dental Surgery, Misr University for Science and Technology
Giza, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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