Could cold plasma make root canals less painful?
NCT ID NCT07747753
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests whether cold atmospheric plasma can match standard sodium hypochlorite irrigation for disinfecting root canals in teeth with dead nerves. Sixty adults with a single necrotic tooth will receive one of the two treatments. Researchers will compare post-treatment pain levels and a healing marker called MMP-9 to see if plasma offers a comparable or better experience.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cold atmospheric plasma applied as a root canal disinfectant
- What this could lead to
- If cold plasma works as well as standard irrigation, it could offer a gentler alternative for root canal treatment, potentially reducing post-procedure pain.
- What could go wrong
- This is a small, early-stage trial, and cold plasma may not match the effectiveness of standard disinfectants. There is also a risk of increased pain or infection if disinfection is less effective.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of dentistry, Cairo University
Cairo, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.