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Melatonin gel tested to help dental implants grip in infected sockets

NCT ID NCT07829393

NEW Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are testing whether a topical melatonin gel helps dental implants stay stable when placed immediately into tooth sockets that had chronic infection. Sixty adults with non-restorable teeth and long-standing apical lesions will receive either standard implant placement with a bone graft or the same procedure plus melatonin gel applied to the implant and graft material. The team will measure implant stability over 12 months using a device that taps the implant, and will also track bone loss, bone density, pain, healing, infection, and implant survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
topical melatonin gel
What this could lead to
If it works, topical melatonin could become a simple add-on that helps dental implants hold firm in sockets that were infected, possibly reducing the need for extra surgery or waiting.
What could go wrong
This is a small, single-center study of 60 people, so results may not apply broadly. Melatonin gel might not improve implant stability, and placing implants into infected sockets carries a risk of infection or implant failure.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jan 2023

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-50 years. * Non-restorable teeth associated with chronic apical lesions persisting after previous endodontic treatment and/or periapical surgery. * Adequate interarch relationship and interocclusal space for prosthetic rehabilitation. * Expected peri-implant jumping gap ≥2 mm. * Good oral hygiene and willingness to comply with follow-up visits. * The chronic periapical lesion of a predefined radiographic size range of \[4 - 10 mm\], measured as the maximum lesion diameter on preoperative CBCT. Exclusion Criteria: * Smokers. * Alcohol or drug abuse. * Pregnancy. * Systemic conditions contraindicating implant placement. * Bruxism or other parafunctional habits. * Inability or unwillingness to maintain oral hygiene or attend follow-up visits.

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Conditions

The condition(s) this trial relates to.

alveolar periostitis chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical periodontitis Dental implantation Infected extraction socket

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    Al Mansurah, 35516, Egypt

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