Tooth enamel regrown with a gel? a new trial explores a drill-free fix for early decay.
NCT ID NCT07730359
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This pilot trial tests a gel called Epinamel that aims to regrow tooth enamel naturally by using minerals from saliva. It includes 20 people who just had their braces removed and have white spot lesions—early signs of decay—on both sides of their mouth. The gel is applied to one side, while a standard treatment is used on the other, to see which works better at shrinking or reversing the lesions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a gel that rebuilds tooth enamel by trapping calcium and phosphate from saliva
- What this could lead to
- If it works, this could offer a simple, natural-looking way to repair early tooth decay without drilling or fillings.
- What could go wrong
- This is a very small pilot study with only 20 participants, so results may not apply widely. The gel is new and unproven compared to existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Guys and St Thomas NHS Foundation Trust Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London
RECRUITINGLondon, SE1 9RT, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.