Can immune therapy help rare muscle disorder?
NCT ID NCT06599697
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether intravenous immunoglobulin (IVIG) can help people with a rare autoimmune muscle disease called anti-HMGCR immune-mediated necrotizing myopathy. Twelve participants will receive either IVIG or a placebo every 4 weeks for 12 weeks, then all may receive IVIG in an open-label extension. The main goal is to see if IVIG lowers muscle enzyme levels and is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Intravenous immunoglobulin (IVIG)
What this could lead to
If it works, this could point toward a treatment for a rare muscle disease that causes weakness and damage.
What could go wrong
This is a very small early-phase trial with only 12 people, so results may not apply widely. IVIG can cause side effects like headache, fever, or allergic reactions.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins University
NOT_YET_RECRUITINGBaltimore, Maryland, 21218, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Pittsburgh
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15260, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Health Science Center at Houston
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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University of Washington
ACTIVE_NOT_RECRUITINGSeattle, Washington, 98195, United States