New pill shows promise for rare bone marrow cancer

NCT ID NCT04176198

Recruiting now Disease control Sponsor: Sumitomo Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests an experimental pill called nuvisertib for people with myelofibrosis, a rare bone marrow disorder. It is for patients whose disease is moderate to high risk and who have not responded well to standard treatments. The goal is to see if the drug is safe and can shrink an enlarged spleen and improve symptoms.

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Conditions

The condition(s) this trial relates to.

myelofibrosis primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELOFIBROSIS

Contacts and locations

Locations

ASST - Spedali Civili di Brescia
RECRUITING

Brescia, Italy
Aichi Medical University Hospital
RECRUITING

Aichi, Japan
Aomori Prefectural Central Hospital
RECRUITING

Aomori, Japan
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
RECRUITING

Alessandria, 15121, Italy
Azienda Ospedaliera Universitaria Citta' Della Salute E della Scienza di Torino
RECRUITING

Torino, 10126, Italy
Baptist Health - Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
Blood Cancer Center
RECRUITING

Denver, Colorado, 80218, United States
CHU Angers
RECRUITING

Angers, 9000, France
CHU de Liege
RECRUITING

Liège, 4000, Belgium
Centre Hospitalier Lyon Sud
RECRUITING

Lyon, 69495, France
Centre Hospitalier Universitaire D'Amiens
RECRUITING

Amiens, 80054, France
City of Hope
RECRUITING

Duarte, California, 91010, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710, United States
Eastern Health Box Hill Hospital
RECRUITING

Box Hill, Victoria, Australia
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Epworth Healthcare
RECRUITING

Richmond, Victoria, Australia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20122, Italy
Hoag Family Cancer Institute
RECRUITING

Newport Beach, California, 92663, United States
Hokkaido University Hospital
RECRUITING

Hokkaido, Japan
Hospital Saint Louis
RECRUITING

Paris, 75010, France
Hospital Universitario de Salamanca
RECRUITING

Salamanca, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Barcelona, Spain
Hospitalier Universitaire (CHU) de Nice - Hopital de l'Archet
RECRUITING

Nice, 06200, France
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS Azienda Ospedaliero -Universitaria Di Bologna - Dipartimento Malattie Oncologiche ed Ematologiche - UO Ematologia
RECRUITING

Bologna, 40138, Italy
IRCCS istituto Romagnolo per lo studio dei tumori "Dino Amadori"
RECRUITING

Meldola, 47014, Italy
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Icon Cancer Centre (Ashford Cancer Centre Research)
RECRUITING

Adelaide, Australia
Institut Catala d'Oncologia
RECRUITING

Barcelona, Spain
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Institut de cancerologie du Gard
RECRUITING

Nîmes, 30029, France
Institut de cancerologie du Gard
RECRUITING

Nîmes, France
Istituto Nazionale Tumori, IRCCS Centro di Riferimento Oncologico di Aviano
RECRUITING

Aviano, 33081, Italy
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Juntendo University Hospital
RECRUITING

Tokyo, Japan
Juravinski Cancer Center
NOT_YET_RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kyushu University Hospital
RECRUITING

Fukuoka, Japan
Lincoln County Hospital
RECRUITING

Lincoln, United Kingdom
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77054, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mie University Hospital
RECRUITING

Tsu, Japan
Monash University
RECRUITING

Clayton, Victoria, Australia
Montefiore Cancer Center
RECRUITING

The Bronx, New York, 10461, United States
National Cancer Center Hospital East
RECRUITING

Chiba, Japan
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Okayama University Hospital
RECRUITING

Okayama, Japan
Oxford University Hospitals NHS Foundation
RECRUITING

Oxford, United Kingdom
Peter McCallum Center
RECRUITING

Melbourne, Victoria, Australia
Princess Margaret Cancer Center
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Roswell Park Comprehensive Cancer Center
COMPLETED

Buffalo, New York, 14263, United States
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, Australia
Saitama Medical Center
COMPLETED

Saitama, Japan
Shizuoka Cancer Center
COMPLETED

Shizuoka, Japan
Shonan Kamakura General Hospital
RECRUITING

Kamakura, 247-8533, Japan
St Vincent's Hospital Melbourne
RECRUITING

Fitzroy, Victoria, Australia
St. Paul's Hospital Hematology/Oncology Research
RECRUITING

Vancouver, British Columbia, V6T 1Z3, Canada
The University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85724, United States
The University of Osaka Hospital
RECRUITING

Osaka, Japan
Tohoku University Hospital
RECRUITING

Sendai, Japan
Tokyo Medical University Hospital
RECRUITING

Tokyo, 160-0023, Japan
Tri-Star Centennial Medical Center
RECRUITING

Nashville, Tennessee, 37203, United States
United Lincolnshire Hospitals NHS Trust - Pilgrim Hospital
RECRUITING

Lincoln, United Kingdom
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
University College London Hospital's NHS foundation Trust
RECRUITING

London, United Kingdom
University Hospital of Poitiers
RECRUITING

Poitiers, 86021, France
University Hospitals Leuven
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
University of Alabama
RECRUITING

Birmingham, Alabama, 35294, United States
University of British Columbia
RECRUITING

Vancouver, British Columbia, V6T 1Z3, Canada
University of Calgary
RECRUITING

Calgary, Alberta, T2N 1N4, Canada
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Florida Health Shands Cancer Hospital
COMPLETED

Gainesville, Florida, 32608, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Miyazaki Hospital
RECRUITING

Miyazaki, Japan
University of Southern California
RECRUITING

Los Angeles, California, 90033, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Washington - Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Universitätsklinikum Schleswig-Holstein
RECRUITING

Lübeck, Germany
Universitätsmedizin Halle
RECRUITING

Halle, Germany
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States
ZNA Cadix
RECRUITING

Antwerp, 2020, Belgium
ZNA Middelheim
RECRUITING

Antwerp, 2030, Belgium

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