New hope for psoriatic arthritis sufferers: experimental drug sonelokimab enters final testing phase

NCT ID NCT06641089

Recruiting now Disease control Sponsor: MoonLake Immunotherapeutics AG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called sonelokimab for adults with active psoriatic arthritis who have not improved with or cannot take standard TNF-blocker medications. About 600 participants will receive either sonelokimab, a placebo, or an existing drug (risankizumab) for comparison. The main goal is to see if sonelokimab reduces joint pain and swelling by at least 50%.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

sonelokimab

What this could lead to

If successful, sonelokimab could offer a new treatment option for people with psoriatic arthritis who have not responded to or cannot tolerate current TNF-blocker therapies.

What could go wrong

This is a Phase 3 trial, but it is still experimental. The drug may not prove more effective than existing treatments, and side effects are possible. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS, PSORIATIC

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Gyula, 5700, Hungary
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Sabadell, 08208, Spain
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Avondale, Arizona, 85392, United States
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Chandler, Arizona, 85225, United States
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Flagstaff, Arizona, 86001, United States
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Mesa, Arizona, 85210, United States
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Phoenix, Arizona, 85032, United States
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Scottsdale, Arizona, 85260, United States
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Tucson, Arizona, 85748, United States
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Jonesboro, Arkansas, 72401, United States
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La Jolla, California, 92037, United States
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Pomona, California, 91767, United States
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San Diego, California, 92108, United States
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Santa Monica, California, 90404, United States
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Thousand Oaks, California, 91360, United States
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Upland, California, 91786, United States
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Avon Park, Florida, 33825, United States
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Clearwater, Florida, 33765, United States
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Hialeah, Florida, 33016, United States
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Miami Gardens, Florida, 33014, United States
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Tampa, Florida, 33607, United States
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Zephyrhills, Florida, 33542, United States
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Gainesville, Georgia, 30501, United States
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Springfield, Illinois, 62702, United States
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Lake Charles, Louisiana, 70605, United States
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Baltimore, Maryland, 21224-6821, United States
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Grand Blanc, Michigan, 48439-2451, United States
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Brooklyn, New York, 11201, United States
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Rochester, New York, 14642, United States
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Charlotte, North Carolina, 28262, United States
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Leland, North Carolina, 28451, United States
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Middleburg Heights, Ohio, 44130, United States
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Portland, Oregon, 97239, United States
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Duncansville, Pennsylvania, 16635, United States
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Jackson, Tennessee, 38305, United States
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Memphis, Tennessee, 38119, United States
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Murfreesboro, Tennessee, 37128, United States
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Allen, Texas, 75013, United States
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Austin, Texas, 78745, United States
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Baytown, Texas, 77521, United States
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Colleyville, Texas, 76034, United States
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Houston, Texas, 77089, United States
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Lubbock, Texas, 79424, United States
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Plano, Texas, 75024, United States
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Seattle, Washington, 98122, United States
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Beckley, West Virginia, 25801, United States
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Pazardzhik, 4400, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4001, Bulgaria
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Plovdiv, 4002, Bulgaria
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Plovdiv, 4003, Bulgaria
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Plovdiv, 4004, Bulgaria
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Rousse, 7000, Bulgaria
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Sofia, 1606, Bulgaria
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Sofia, 1784, Bulgaria
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Stara Zagora, 6003, Bulgaria
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Toronto, Ontario, M5S1B2, Canada
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Calgary, T2N 4L7, Canada
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Trois-Rivières, G9A 3X2, Canada
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Waterloo, N2J 1C4, Canada
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Winnipeg, R3A IM3, Canada
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Brno, 63800, Czechia
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Ostrava, 70200, Czechia
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Studénka, 742 13, Czechia
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Zlín, 760 01, Czechia
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Caluire-et-Cuire, 69300, France
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Montpellier, 34295, France
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Narbonne, 11100, France
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Nice, 06001, France
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Rouen, 76031, France
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Tours, 37170, France
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Tbilisi, 0102, Georgia
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Tbilisi, 0112, Georgia
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Tbilisi, 0141, Georgia
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Tbilisi, 0159, Georgia
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Tbilisi, 0179, Georgia
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Tbilisi, 0180, Georgia
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Berlin, 12161, Germany
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Berlin, 12203, Germany
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Berlin, 13125, Germany
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Dresden, 01067, Germany
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Erlangen, 91054, Germany
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Hamburg, 20095, Germany
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Herne, 44649, Germany
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Munich, 80639, Germany
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Munich, 81667, Germany
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München, 80336, Germany
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Budapest, 1027, Hungary
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Budapest, 1036, Hungary
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Budapest, 1036, Hungary
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Debrecen, H-4032, Hungary
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Hódmezővásárhely, 6800, Hungary
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Nyíregyháza, 4400, Hungary
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Székesfehérvár, 8000, Hungary
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Szolnok, 5000, Hungary
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Veszprém, 8200, Hungary
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Bialystok, 15707, Poland
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Bydgoszcz, 85-065, Poland
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Częstochowa, 42-202, Poland
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Elblag, 82-300, Poland
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Gdynia, 81-384, Poland
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Krakow, 30-002, Poland
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Krakow, 30-149, Poland
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Krakow, 31-501, Poland
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Lodz, 91-363, Poland
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Nadarzyn, 05-830, Poland
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Poznan, 60-324, Poland
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Poznan, 60-446, Poland
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Poznan, 60-693, Poland
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Poznan, 61-397, Poland
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Sochaczew, 96-500, Poland
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Swidnica, 58100, Poland
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Warsaw, 00-874, Poland
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Warsaw, 02-118, Poland
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Warsaw, 02-665, Poland
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Warsaw, 02-677, Poland
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Warsaw, 02-786, Poland
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Warsaw, 03-291, Poland
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Warsaw, 04-305, Poland
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Wołomin, 05-200, Poland
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Wroclaw, 51-685, Poland
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Wroclaw, 53-673, Poland
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A Coruña, 15006, Spain
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Alcobendas, 28100, Spain
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Bilbao, 48013, Spain
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Castellon, 12004, Spain
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Madrid, 28003, Spain
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Málaga, 29009, Spain
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Santiago de Compostela, 15702, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41009, Spain
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Seville, 41010, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Westcliff-on-Sea, Essex, SS0, United Kingdom
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Barnet, EN5 3DJ, United Kingdom
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Leeds, LS7 4SA, United Kingdom