Spondyloarthropathy

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This study tests a drug called 608 in 380 adults with non-radiographic axial spondyloarthritis, a form of arthritis that causes back pain and stiffness but doesn't show up on X-rays. Participants will receive either 608 or a placebo injection to see if the drug reduces pain and i…

This study tests a drug called xeligekimab in 40 adults with non-radiographic axial spondyloarthritis, a form of arthritis that causes back pain but doesn't appear on X-rays. Participants receive six injections over 12 weeks, and doctors check if symptoms improve by at least 20%.…

This study tests whether a Mediterranean diet can lower disease activity and improve quality of life in 110 people with axial spondyloarthritis (a type of arthritis affecting the spine) who are already on biologic therapy. Participants will either follow a structured Mediterranea…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This study tests a dietary supplement called GenesiDol for managing muscle and joint pain in people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. About 40 adults with persistent pain will take the supplement for 8 weeks to see if it reduces pa…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests a therapeutic education program designed to improve self-image and self-esteem in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Sixty participants will complete questionnaires and interviews before and after …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study will measure the activity of a gene called TNFAIP3 in 110 people with ankylosing spondylitis or psoriatic arthritis. The goal is to see if the gene's expression is linked to how active the disease is. Researchers will use a blood test to check gene levels and compare t…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study aims to see if there is a connection between two types of inflammatory conditions: one affecting the spine and joints (spondylarthritis) and another affecting blood vessels (giant cell arteritis) or muscles (polymyalgia rheumatica). Researchers will compare 10 adults w…

This study will check if a protein called Tim-3 on certain white blood cells (neutrophils) is linked to disease activity in people with ankylosing spondylitis. Researchers will measure Tim-3 levels and compare them with inflammation markers and MRI scans of the hip and sacroiliac…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at how two different exercise programs—high-intensity intervals and moderate continuous activity—affect a blood marker called irisin, as well as disease activity, physical function, and quality of life in people with axial spondyloarthritis. About 75 adults with …

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …