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New drug tulisokibart aims to ease back pain and stiffness in ankylosing spondylitis

NCT ID NCT07133633

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 29, 2026 · Updated 9 times

Summary

This study tests whether tulisokibart can improve symptoms of radiographic axial spondyloarthritis, a type of arthritis that causes pain and swelling in the spine and pelvis. About 315 adults with active disease will receive either the drug or a placebo for 16 weeks. Researchers will measure improvements in pain, stiffness, and physical function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tulisokibart
What this could lead to
If successful, tulisokibart could offer a new treatment option to reduce pain, stiffness, and inflammation in people with ankylosing spondylitis.
What could go wrong
This is an early-phase trial with only 315 participants, so results may not apply to everyone. The drug may not work better than a placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

spondyloarthropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AARA Arizona Arthritis & Rheumatology Associates, P.C. - Glendale ( Site 0056)

    RECRUITING

    Glendale, Arizona, 85306, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler ( Site 0036)

    RECRUITING

    Chandler, Arizona, 85225, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff ( Site 0021)

    RECRUITING

    Flagstaff, Arizona, 86001, United States

  • AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving ( Site 0032)

    RECRUITING

    Irving, Texas, 75039, United States

  • AARA Clinical Research - Murfreesboro Medical Clinic ( Site 0029)

    RECRUITING

    Murfreesboro, Tennessee, 37128, United States

  • ANKARA UNIVERSITY IBNI SINA HOSPITAL ( Site 1600)

    RECRUITING

    Ankara, 06230, Turkey (Türkiye)

  • Advanced Rheumatology of Houston ( Site 0001)

    RECRUITING

    The Woodlands, Texas, 77382, United States

  • Altoona Center for Clinical Research ( Site 0004)

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Amsterdam UMC ( Site 1101)

    RECRUITING

    Amsterdam, North Holland, 1081 HV, Netherlands

  • Arizona Arthritis & Rheumatology Associates, P.C. - Gilbert ( Site 0022)

    RECRUITING

    Gilbert, Arizona, 85297, United States

  • Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 0025)

    RECRUITING

    Tucson, Arizona, 85704-1140, United States

  • Arthritis Care of Texas ( Site 0048)

    RECRUITING

    Corpus Christi, Texas, 78415, United States

  • Arthritis and Rheumatic Disease Specialties ( Site 0016)

    RECRUITING

    Aventura, Florida, 33180, United States

  • Arthritis and Rheumatism Associates - Rockville ( Site 0019)

    RECRUITING

    Rockville, Maryland, 20850, United States

  • Barnet Hospital ( Site 1806)

    RECRUITING

    Barnet, EN5 3DJ, United Kingdom

  • Bay Area Arthritis and Osteoporosis ( Site 0041)

    RECRUITING

    Brandon, Florida, 33511, United States

  • Bioreuma ( Site 2109)

    RECRUITING

    Concepción, Biobio, 4070280, Chile

  • Bradfordhill ( Site 2110)

    RECRUITING

    Santiago, Region M. de Santiago, 8420383, Chile

  • CIREEM SAS ( Site 2204)

    ACTIVE_NOT_RECRUITING

    Bogota, Cundinamarca, 110221, Colombia

  • CMIP-CENTRO MINEIRO DE PESQUISA ( Site 1999)

    RECRUITING

    Juiz de Fora, Minas Gerais, 36010-570, Brazil

  • Centre de Recherche Musculo-Squelettique ( Site 0202)

    RECRUITING

    Trois-Rivières, Quebec, G9A 3Y2, Canada

  • Centro de Estudios GyC ( Site 2103)

    RECRUITING

    Santiago, Region M. de Santiago, 7500504, Chile

  • Centro de Pesquisas Clínicas do Hospital das Clínicas de São Paulo ( Site 1992)

    RECRUITING

    São Paulo, 05403-000, Brazil

  • Chang Gung Memorial Hospital - Linkou Branch ( Site 2904)

    RECRUITING

    Taoyuan, 33305, Taiwan

  • Chang Gung Memorial Hospital at Kaohsiung ( Site 2908)

    RECRUITING

    Kaohsiung City, 833, Taiwan

  • Charite Universitätsmedizin Berlin Campus Benjamin Franklin-Medizinische Klinik I für Gastroenterol ( Site 0601)

    RECRUITING

    Berlin, 12203, Germany

  • Chicago Arthritis & Regenerative Medicine ( Site 0042)

    RECRUITING

    Chicago, Illinois, 60661, United States

  • Chinese Academy of Medical Science Peking Union Medical College Hospital ( Site 3100)

    RECRUITING

    Beijing, Beijing Municipality, 100005, China

  • Clinica Alemana Osorno ( Site 2114)

    RECRUITING

    Osorno, Los Lagos Region, 5311089, Chile

  • Clinica de la Costa S.A.S. ( Site 2202)

    RECRUITING

    Barranquilla, Atlántico, 080020, Colombia

  • Cohen Medical Centers ( Site 0034)

    RECRUITING

    Thousand Oaks, California, 91360-3967, United States

  • Communal Nonprofit Enterprise Cherkasy Regional Hospital of Cherkasy Oblast Council ( Site 1704)

    RECRUITING

    Cherkasy, Chernivetska Oblast, 18009, Ukraine

  • Complexo Hospital de Clínicas da Universidade Federal do Paraná ( Site 1991)

    RECRUITING

    Curitiba, Paraná, 80060-900, Brazil

  • DM Clinical Research - TRA ( Site 0010)

    RECRUITING

    Tomball, Texas, 77375, United States

  • Enroll SpA ( Site 2101)

    RECRUITING

    Santiago, Region M. de Santiago, 7500587, Chile

  • Epic Medical Research ( Site 0061)

    RECRUITING

    Red Oak, Texas, 75154, United States

  • First Affiliated Hospital of Kunming Medical University ( Site 3123)

    RECRUITING

    Kunming, Yunnan, 650032, China

  • Fundación Valle del Lili ( Site 2201)

    RECRUITING

    Cali, Valle del Cauca Department, 760032, Colombia

  • G.R.M.O. (Groupe de recherche en maladies osseuses) Inc. ( Site 0200)

    RECRUITING

    Québec, Quebec, G1V 4K5, Canada

  • GNP Research - Hollywood ( Site 0020)

    RECRUITING

    Cooper City, Florida, 33024, United States

  • Guangdong Provincial People's Hospital ( Site 3110)

    RECRUITING

    Guangzhou, Guangdong, 510080, China

  • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg G ( Site 0604)

    RECRUITING

    Hamburg, 20095, Germany

  • Hacettepe Universite Hastaneleri ( Site 1603)

    RECRUITING

    Ankara, 06230, Turkey (Türkiye)

  • Hanyang University Seoul Hospital ( Site 2800)

    RECRUITING

    Seoul, 04763, South Korea

  • IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 1994)

    RECRUITING

    Rio de Janeiro, 20241-180, Brazil

  • Inland Rheumatology Clinical Trials, Inc. ( Site 0002)

    RECRUITING

    Upland, California, 91786, United States

  • Innovation Medical Research Center ( Site 0012)

    RECRUITING

    Palmetto Bay, Florida, 33157, United States

  • Inspire Santa Fe Medical Group ( Site 0011)

    RECRUITING

    Santa Fe, New Mexico, 87505, United States

  • Istanbul University Cerrahpasa Medical School Internal Diseases Institute ( Site 1604)

    RECRUITING

    Fatih, Istanbul, 34098, Turkey (Türkiye)

  • John Hopkins University ( Site 0052)

    RECRUITING

    Baltimore, Maryland, 21224, United States

  • Kansas City Physician Partners ( Site 0027)

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • Kaohsiung Veterans General Hospital ( Site 2905)

    RECRUITING

    Kaohsiung City, 813414, Taiwan

  • Kocaeli Üniversitesi ( Site 1605)

    RECRUITING

    Kocaeli, 41380, Turkey (Türkiye)

  • Konya Necmettin Erbakan Universitesi ( Site 1606)

    RECRUITING

    Konya, 42090, Turkey (Türkiye)

  • Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain ( Site 1701)

    RECRUITING

    Kyiv, 03049, Ukraine

  • Kyung Hee University Hospital ( Site 2803)

    RECRUITING

    Seoul, 02447, South Korea

  • Kyung Hee University Hosptial at Gangdong ( Site 2802)

    RECRUITING

    Seoul, 05278, South Korea

  • LMK Serviços Médicos S/S ( Site 2000)

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90480-000, Brazil

  • Logan Health Rheumatology ( Site 0015)

    RECRUITING

    Kalispell, Montana, 59901, United States

  • Lone Star Arthritis & Rheumatology Associates, P.C. ( Site 0028)

    RECRUITING

    Fort Worth, Texas, 76109, United States

  • Lviv Clin Hospital of Planned Treatment Rehabilitation Palliative Care ( Site 1710)

    RECRUITING

    Lviv, Lviv Oblast, 79011, Ukraine

  • ME "Ternopil Regional Clinical Hospital of Ternopil Regional Council" ( Site 1707)

    RECRUITING

    Ternopil, Ternopil Oblast, 46002, Ukraine

  • MICS Centrum Medyczne Bydgoszcz ( Site 1206)

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-065, Poland

  • MICS Centrum Medyczne Torun ( Site 1202)

    RECRUITING

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

  • MICS Centrum Medyczne Warszawa ( Site 1204)

    RECRUITING

    Warsaw, Masovian Voivodeship, 00-874, Poland

  • Maasstad Ziekenhuis ( Site 1102)

    RECRUITING

    Rotterdam, South Holland, 3079DZ, Netherlands

  • Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 1602)

    RECRUITING

    Istanbul, 34899, Turkey (Türkiye)

  • Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 1706)

    RECRUITING

    Kyiv, 03057, Ukraine

  • Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 1715)

    RECRUITING

    Kyiv, Kyivska Oblast, 04050, Ukraine

  • Medicover München Ost MVZ ( Site 0611)

    RECRUITING

    Munich, Bavaria, 81667, Germany

  • Municipal Non-Profit Enterprise "Khmelnytskyi Regional Hospital" of Khmelnytskyi Regional Council ( Site 1713)

    RECRUITING

    Khmelnytskiy, Khmelnytskyi Oblast, 29000, Ukraine

  • Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia ( Site 1700)

    RECRUITING

    Vinnytsa, Vinnytsia Oblast, 21018, Ukraine

  • Municipal Public Non-Profit Enterprise "City Clinical Hospital №1 of the Ivano-Frankivsk City Counc ( Site 1705)

    RECRUITING

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

  • Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im.Prof. El. Reicher-ul.Spartanska 1 ( Site 1205)

    ACTIVE_NOT_RECRUITING

    Warsaw, Masovian Voivodeship, 02-637, Poland

  • National Cheng Kung University Hospital ( Site 2903)

    RECRUITING

    Tainan, 704, Taiwan

  • National Taiwan University Hospital ( Site 2902)

    RECRUITING

    Taipei City, Taipei, 100, Taiwan

  • Newport Huntington Medical Group ( Site 0005)

    RECRUITING

    Huntington Beach, California, 92648, United States

  • Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 1800)

    RECRUITING

    Norwich, Norfolk, NR4 7UY, United Kingdom

  • Oregon Health & Science University ( Site 0059)

    RECRUITING

    Portland, Oregon, 97239, United States

  • PEOPLE'S HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION ( Site 3124)

    RECRUITING

    Ürümqi, Xinjiang, 830001, China

  • Perelman Center for Advanced Medicine ( Site 0060)

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Physician Research Collaboration, LLC ( Site 0057)

    RECRUITING

    Lincoln, Nebraska, 68516-5497, United States

  • Pingxiang People's Hospital ( Site 3115)

    RECRUITING

    Pingxiang, Jiangxi, 337055, China

  • Provecta Research Network LLC ( Site 0054)

    RECRUITING

    Houston, Texas, 77027, United States

  • Providence Medical Foundation ( Site 0049)

    RECRUITING

    Fullerton, California, 92835, United States

  • Rheuma-Research Lausitz ( Site 0609)

    RECRUITING

    Cottbus, Brandenburg, 03042, Germany

  • Rheumatologische Schwerpunktpraxis ( Site 0605)

    RECRUITING

    Berlin, 10777, Germany

  • Rheumatology Associates ( Site 0055)

    RECRUITING

    Arlington, Texas, 76012, United States

  • Rheumazentrum Ratingen Studienambulanz ( Site 0602)

    RECRUITING

    Ratingen, North Rhine-Westphalia, 40878, Germany

  • Rheumazentrum Ruhrgebiet ( Site 0600)

    RECRUITING

    Herne, North Rhine-Westphalia, 44649, Germany

  • Royal United Hospital Bath NHS Foundation Trust ( Site 1803)

    RECRUITING

    Bath, Somerset, BA1 3NG, United Kingdom

  • St Luke's Hospital ( Site 1801)

    RECRUITING

    Bradford, BD5 0NA, United Kingdom

  • Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy ( Site 1203)

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland

  • Taipei Medical University Shuang Ho Hospital ( Site 2900)

    RECRUITING

    New Taipei City, New Taipei, 235, Taiwan

  • Taipei Veterans General Hospital ( Site 2906)

    RECRUITING

    Taipei, 112, Taiwan

  • The First Affiliated Hospital of Henan University of Science &Technology ( Site 3121)

    RECRUITING

    Luoyang, Henan, 471003, China

  • The First Afflilated Hospital of Bengbu Medical College ( Site 3119)

    RECRUITING

    Bengbu, Anhui, 233004, China

  • The First Hospital Of Jilin University ( Site 3103)

    RECRUITING

    Changchun, Jilin, 130021, China

  • The Third Affiliated Hospital of Sun Yat-Sen University ( Site 3114)

    RECRUITING

    Guangzhou, Guangdong, 510630, China

  • TriWest Research Associates - Chula Vista ( Site 0013)

    COMPLETED

    Chula Vista, California, 91910, United States

  • Velocity Clinical Research - West County Rheumatology, St. Louis ( Site 0038)

    RECRUITING

    St Louis, Missouri, 63131, United States

  • Willow Rheumatology and Wellness, PLLC ( Site 0035)

    RECRUITING

    Willowbrook, Illinois, 60527, United States

  • Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 1201)

    RECRUITING

    Lublin, Lublin Voivodeship, 20-607, Poland

  • Zuyderland Medical Centre ( Site 1100)

    RECRUITING

    Heerlen, Limburg, 6419 PC, Netherlands

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