Celiac disease

This early-phase study tests whether combining mesenchymal stem cells (MSCs) with specially engineered immune cells (CAR-T cells) is safe and can help control autoimmune diseases. About 30 adults with established autoimmune conditions will receive the treatment and be monitored f…

This study tests whether specially engineered immune cells, called CAR-T cells, can safely treat autoimmune diseases. The cells are designed to target and suppress B cells, which play a key role in many autoimmune conditions. The trial involves 30 adults and focuses on safety and…

This study is testing a new blood filter called the Plasma Filter PX2. It is used in a procedure called therapeutic plasma exchange, which removes harmful substances from the blood of people with autoimmune diseases. About 46 adults will take part, and the study will check if the…

This early-stage trial tests a new medicine called VTP-1000 in 45 adults with celiac disease. The goal is to see if it is safe and how the body handles it, especially when exposed to gluten. Participants will receive either the drug or a placebo, and some will take a controlled g…

This study is testing whether a portable gluten-detection device, combined with regular telemedicine check-ins with a dietitian, can improve gut healing in adults newly diagnosed with celiac disease. Two hundred participants will use the technology and receive expert guidance to …

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests an experimental drug called DONQ52 in people with active celiac disease who still have gut damage and symptoms even after following a gluten-free diet for at least a year. About 92 adults will receive either the drug or a placebo to see if it can heal the small i…

This study tests whether taking omega-3 supplements (2.4 grams daily for 3 months) can lower inflammation and improve intestinal healing in adults newly diagnosed with celiac disease. Participants will also follow a gluten-free diet. The goal is to see if adding omega-3s helps mo…

This study tests whether a special type of iron supplement (Sucrosomial iron) helps children with celiac disease who also have low iron or anemia. The trial will compare children who take the supplement plus a gluten-free diet to those who only follow the diet. The goal is to see…

This study tests an oral drug called ZED1227 in 356 adults with celiac disease who still have symptoms like stomach pain and bloating even after following a gluten-free diet for at least a year. Participants will receive either the drug or a placebo for several weeks to see if sy…

This early-stage study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy works by directing the body's immune cells to attack and control overactive immune cells causing the disease. The study will…

This study tests a new biologic drug called FB102 in 100 adults with celiac disease who already follow a strict gluten-free diet. Participants will receive either FB102 or a placebo and then undergo a controlled gluten challenge to see if the drug can reduce intestinal damage and…

This early study tests a single oral dose of HB-2121 in 20 adults with suspected celiac disease. The dye is given four hours before a standard endoscopy to see how it interacts with the small intestine and whether it is safe. Researchers will track side effects and measure the dy…

This study will collect capsule endoscopy images from 10,000 patients to train an artificial intelligence system to detect bowel diseases, Crohn's disease, celiac disease, chronic diarrhea, and tumors. The goal is to improve diagnostic accuracy and reduce the time doctors spend r…

This study is testing whether an artificial intelligence system can help doctors find signs of damage in the small bowel during endoscopy. The AI is trained to spot atrophy and other abnormalities linked to celiac disease and similar conditions. Researchers will compare the AI's …

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This pilot study tests whether a new, faster radiation planning method can safely ease severe abdominal pain caused by advanced cancer. Instead of a separate planning session, doctors use existing scans to create a treatment plan on the spot. Only 5 people will take part, and the…

This study tests a nutrition education program for children ages 2 to 18 recently diagnosed with celiac disease. The program focuses on eating naturally gluten-free foods and avoiding ultra-processed gluten-free options. Researchers will compare this approach to standard gluten-f…

This study looks at whether eating a special artisanal bread made with whole wheat flour and sourdough can reduce stomach discomfort in people who usually feel sick after eating regular bread. Forty adults who are intolerant to conventional bread but do not have celiac disease wi…

This study tests whether a special toothpaste and mousse can reduce tooth sensitivity and enamel damage in adults with celiac disease. Forty participants will either use the toothpaste alone or add a nightly mousse for six months. Researchers will measure changes in sensitivity, …

This study tests whether a daily probiotic drink called Symprove can relieve ongoing gut symptoms like bloating, pain, and diarrhoea in adults with coeliac disease who already follow a strict gluten-free diet. About 24 participants will take the probiotic and report symptom chang…

This study tracks how well a nerve block procedure called celiac plexus neurolysis (CPN) helps manage pain in people with chronic pancreatitis. Researchers will follow 35 patients for 24 weeks, recording their pain scores and pain medication use. The goal is to see if the procedu…

This study explores whether removing wheat and cow's milk from the diet can reduce inflammation and improve skin symptoms in people with mild-to-moderate psoriasis. 82 participants will follow either a wheat- and dairy-free diet or a control diet for 2 months, then some will be r…

This study tests whether a mobile app, supported by a nurse, can improve quality of life for adults newly diagnosed with celiac disease. Sixty participants will either use the app for six months or receive standard education. The goal is to see if the app helps with diet adherenc…

This study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…

This study will analyze DNA from up to 20,000 people, including those with immune disorders and their relatives, to find genetic variants linked to conditions like atopy, autoimmunity, and primary immunodeficiency. Researchers will also study how best to return genetic results to…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study is measuring a protein called STIM1 on the surface of immune cells in 670 people with various autoimmune diseases. The goal is to find which diseases have high levels of this protein, which could help researchers develop new antibody-based treatments. Participants prov…

This study compares using one doctor versus two doctors to perform a procedure called single-balloon enteroscopy, which looks deep into the small intestine. About 228 adults with suspected small bowel disease will be randomly assigned to either technique. The goal is to see if on…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This study aims to learn more about how celiac disease damages the gut and how it heals. Researchers will look at gut cells, bacteria, the immune system, and genetics in 220 adults. The goal is to better understand symptoms and improve care for people with celiac disease.

This study is collecting health information, lifestyle data, and biological samples from up to 100,000 adults to help researchers better understand diseases like lupus, celiac disease, and kidney disease. Participants provide data and samples through a direct-to-patient platform.…

This study looks at how often children with celiac disease also have fatty liver disease, and whether a gluten-free diet helps. Researchers will review medical records of 91 children to track changes before and after starting the diet. The goal is to better understand the link be…

This study is collecting small intestine tissue samples from 300 adults to better understand and diagnose celiac disease and other small-bowel conditions. Researchers will use advanced techniques like AI image analysis and genetic profiling to create more reliable diagnostic tool…

This study looks at how the immune system of children with celiac disease responds to tiny, controlled amounts of gluten. About 51 kids on a strict gluten-free diet will get either a placebo, a small dose (50 mg), or a larger dose (5 g) of gluten daily for three days. Researchers…

This study involves 40 people with non-celiac gluten/wheat sensitivity who are already on a gluten-free diet. Researchers will use a new urine test to detect gluten proteins, checking if participants accidentally eat gluten and whether that links to their symptoms. The goal is to…

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study follows 500 infants who have a close family member with celiac disease. Researchers track their genes, diet, gut bacteria, and other factors from birth to see what leads to the disease. The goal is to find ways to predict or prevent celiac disease in children who are a…

This study looks at how people with celiac disease react to gluten in liquid form (a shake) versus solid form (a cookie). Thirty adults on a gluten-free diet will try both, in random order, with blood samples taken to measure immune markers and symptoms. The goal is to see if liq…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study compares a pre-recorded, on-demand webinar led by dietitians to traditional one-on-one appointments for people newly diagnosed with coeliac disease. Sixty adults will be split into two groups to see if the webinar is just as effective at teaching them how to follow a s…

This study is testing whether it's practical to screen thousands of children for type 1 diabetes and celiac disease during their regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 and follow them for about 5 years. The goal is to see if paren…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study tests whether using a predictive model before a double-balloon enteroscopy helps doctors fully examine the small intestine. About 338 adults with suspected small-bowel disease will be randomly assigned to have their doctor see the model score or not. The main goal is t…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study is looking at why the immune system attacks the gut in people with celiac disease and other immune-related gut disorders. Researchers will collect blood and tissue samples from 200 adults to study immune cells and genes. The goal is to better understand what goes wrong…

This study is looking at 3,500 adults with celiac disease, dermatitis herpetiformis (a related skin condition), and their healthy friends or family. Researchers want to find genetic and biological markers that explain why the disease looks different in different people. No treatm…