Celiac disease

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This study looked at whether a probiotic called LP-LDL can lower cholesterol and improve heart health in adults with celiac disease. 50 participants took the probiotic to see if it reduced their cholesterol levels and body mass index. The goal was to find a safe way to manage hea…

This study tested whether the drug ritlecitinib could prevent intestinal damage and symptoms when people with celiac disease ate gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. Th…

This early-phase trial tested a new drug called VIS171 in 61 people: first in healthy volunteers, then in patients with autoimmune diseases. The main goal was to check safety and how the body processes the drug. No results on whether it actually helps the disease are available ye…

This Phase 2 trial tested whether TAK-101, given as an intravenous infusion, can reduce gluten-related symptoms and immune activation in adults with well-controlled celiac disease who follow a gluten-free diet. Participants received two doses of TAK-101 or placebo, and all were l…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested a drug called KAN-101 in 55 adults with celiac disease who had been on a gluten-free diet for at least a year. Participants received either KAN-101 or a placebo, then underwent a two-week gluten challenge. The drug appeared to reduce gluten-induced damage to the…

This study tested a new drug called TPM502 in 28 adults with celiac disease. The goal was to see if two infusions of TPM502 could safely train the immune system to tolerate gluten, potentially reducing the need for a lifelong gluten-free diet. Participants received either TPM502 …

This study looked at a device called GLOBAFFIN that filters antibodies from the blood to help people with autoimmune diseases. It involved 34 adults and measured how much harmful antibodies were removed and if patients felt better. The goal was to see if the device is safe and wo…

This early-stage study tested whether a single oral dose of HB-2121 is safe in adults. Researchers monitored 18 participants for side effects and tracked how the drug moves through the body over 30 days. The goal is to develop a new way to diagnose celiac disease.

This study looked at 208 children who had a procedure called balloon enteroscopy to find problems in the small intestine. Researchers compared two types—single-balloon and double-balloon—to see which one worked better and was safer. The goal was to help doctors choose the best me…

This study looked at whether a newer type of blood test (CLIA) can reliably diagnose celiac disease without needing a biopsy of the small intestine. Researchers analyzed data from 765 adults who had both the blood test and a biopsy. The goal was to find the right cutoff value tha…

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study looked at whether cutting out certain carbs (FODMAPs) can help people with celiac disease who still have stomach issues even after following a gluten-free diet. Researchers surveyed and then ran a controlled trial with 80 adults who had celiac disease and irritable bow…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested a drug called PRV-015 in 388 adults with celiac disease who still had symptoms like belly pain and bloating even after following a strict gluten-free diet. The goal was to see if the drug could reduce these symptoms better than a placebo. Participants took the d…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This completed study looked at how common celiac disease is in Spain and what factors might influence it. Researchers tested nearly 5,000 people of all ages across five regions using blood tests and biopsies. They aimed to understand why earlier studies found different rates in c…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study tested a special gluten-free food guide designed to help children and teens (ages 5-18) with newly diagnosed celiac disease eat a healthier diet. Forty participants received either standard care or the new guide. Researchers measured diet quality and how well they foll…

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This completed study from Oslo University Hospital involved 33 adults with celiac disease who followed a strict gluten-free diet. Over five separate one-day challenges, participants consumed wheat gluten, barley gluten, hydrolyzed barley gluten, or a placebo. Researchers measured…

This study looked at 500 women with non-celiac wheat sensitivity (NCWS) to see if they have more gynaecological issues than healthy women or those with celiac disease or irritable bowel syndrome. Researchers also tested whether a gluten-free diet could improve these problems. A s…

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This study involved 71 children with celiac disease who follow a lifelong gluten-free diet. Researchers measured their eating habits, symptoms, and quality of life, and looked for biomarkers in blood and stool to better monitor their health. The goal was to understand dietary imb…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…

This completed observational study collected over 3,700 PillCam SB3 capsule endoscopy videos from standard care procedures. The goal was to build a large database of images showing both normal and diseased small intestine tissue. Researchers will use this data to develop and vali…