Celiac disease
MONDO:0005130An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
Also known as: celiac disease, celiac sprue, coeliac sprue, gluten intolerance, gluten-induced enteropathy, non tropical sprue
112 clinical trials for this condition and its sub-types.
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Broader categories
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Experimental drug aims to tame stubborn autoimmune diseases
Disease control Not yet recruitingThis early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …
Phase: NA • Sponsor: Starna Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug STR-P005 aims to tame stubborn autoimmune diseases
Disease control Not yet recruitingThis early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …
Phase: NA • Sponsor: Beijing GoBroad Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Pee test could catch hidden gluten in kids with celiac disease
Diagnosis Not yet recruitingThis study tests a urine test that detects gluten peptides in children with celiac disease who are on a gluten-free diet. The goal is to see if this test helps doctors and families identify accidental gluten exposure better than standard blood tests. One hundred children aged 2 t…
Phase: NA • Sponsor: Fondation Lenval • Aim: Diagnosis
Last updated Jun 27, 2026 12:31 UTC
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New test helps polish families track Gluten-Free diet in kids
Diagnosis Not yet recruitingThis study aims to translate and validate the Celiac Dietary Adherence Test (CDAT) for Polish children with celiac disease. Researchers will enroll 20 participants aged 2 to 18, along with their caregivers, to check if the Polish version accurately measures how well they follow a…
Sponsor: Medical University of Warsaw • Aim: Diagnosis
Last updated Jun 26, 2026 12:56 UTC
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Could one antibiotic dose before tooth pulling prevent infections in Immune-Weakened patients?
Prevention Not yet recruitingThis study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …
Phase: PHASE4 • Sponsor: University of Sao Paulo General Hospital • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC
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Gluten-Free diet tested as back pain remedy
Symptom relief Not yet recruitingThis study looks at whether a gluten-free diet can reduce inflammatory back pain. Researchers will split 50 people into two groups: one gets standard treatment, the other adds a gluten-free diet for a year. They'll measure pain levels and immune markers to see if the diet makes a…
Phase: NA • Sponsor: University of Palermo • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Painless ultrasound may spot celiac Flare-Ups without a needle
Knowledge-focused Not yet recruitingThis study explores whether a simple ultrasound and a blood test can track celiac disease activity, potentially replacing the need for invasive intestinal biopsies. Researchers will scan the small bowel and measure antibody levels in 140 people, including newly diagnosed patients…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can hospitals boost vaccine access for the most vulnerable?
Knowledge-focused Not yet recruitingThis study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Gluten-Free diet may sharpen Teens' brains and balance, study hints
Knowledge-focused Not yet recruitingThis observational study will compare teens with celiac disease who follow a gluten-free diet strictly versus those who don't, along with healthy peers. Researchers will test walking while doing mental tasks, memory, attention, muscle strength, quality of life, and fatigue. The g…
Sponsor: Inonu University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Screening for celiac disease: could early diagnosis improve lives?
Knowledge-focused Not yet recruitingThis study follows 250 adults in Finland who were previously screened for celiac disease to see how early diagnosis affects their long-term health, diet habits, and quality of life. Researchers will track symptoms, gluten-free diet adherence, and overall well-being. The goal is t…
Sponsor: Tampere University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Teens with celiac disease: are their eating habits at risk?
Knowledge-focused Not yet recruitingThis study looks at eating behaviors in teenagers aged 11-17 with celiac disease compared to healthy teens. Participants fill out questionnaires about their eating habits and concerns. A smaller group newly diagnosed with celiac disease will be followed for two years to see how t…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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New app aims to help kids with celiac disease avoid hidden gluten
Knowledge-focused Not yet recruitingThis study tests a digital diary called MyMedDiary in 120 children (ages 2-18) newly diagnosed with celiac disease. The app helps families track gluten-free foods and spot hidden sources of gluten. Researchers want to see if the app improves diet adherence compared to traditional…
Phase: NA • Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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New tests could help kids with celiac disease stay on track
Knowledge-focused Not yet recruitingThis study looks at 140 children with celiac disease, ages 2 to 18, who have been on a gluten-free diet for at least 6 months. Researchers will compare a questionnaire and rapid urine/stool tests to standard blood tests to see which methods best measure diet adherence. The goal i…
Sponsor: Medical University of Warsaw • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:56 UTC
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New study to track hidden salt and mineral imbalances in sick kids
Knowledge-focused Not yet recruitingThis study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:41 UTC