New hope for celiac sufferers: drug targets stubborn symptoms despite Gluten-Free diet
NCT ID NCT07298343
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an oral drug called ZED1227 in 356 adults with celiac disease who still have symptoms like stomach pain and bloating even after following a gluten-free diet for at least a year. Participants will receive either the drug or a placebo for several weeks to see if symptoms improve. The goal is to find a treatment that helps when diet alone isn't enough.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ZED1227 (an oral drug)
What this could lead to
If successful, this could provide a new treatment option for celiac disease patients who still have symptoms even on a strict gluten-free diet.
What could go wrong
This is a Phase 2 trial, so it's still early. The drug may not prove effective or could have side effects. Results may not apply to all celiac patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University Medical Center Mainz
RECRUITINGMainz, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••