CELIAC DISEASE

This is the first human trial testing VTP-1000, a new nanoparticle-based therapy for celiac disease. The study aims to see if the treatment is safe and can help the immune system tolerate gluten, potentially reducing the body's harmful reaction. It will involve 45 adults with cel…

This study is testing whether an experimental drug called DONQ52 can help people with celiac disease who still experience intestinal damage and symptoms despite following a gluten-free diet. The trial will involve 92 participants who will receive either DONQ52 or a placebo for 27…

This study is testing an investigational drug called TEV-53408 to see if it can protect the gut lining in adults with celiac disease when they are exposed to gluten. The trial will involve about 48 participants who will take the drug or a placebo while undergoing controlled glute…

This study is testing whether an experimental drug called FB102 can help protect adults with celiac disease when they accidentally eat gluten. Researchers will give 100 participants either the drug or a placebo, then intentionally give them a small amount of gluten to see how the…

This study is testing if a drug called ritlecitinib can protect people with well-managed celiac disease from intestinal damage and symptoms if they accidentally eat gluten. Forty participants will take either the drug or a placebo pill daily while also consuming a small, controll…

This study is testing a new artificial intelligence (AI) system designed to help doctors diagnose celiac disease and similar gut conditions. The AI is trained to spot signs of intestinal damage in images from endoscopy procedures. Researchers will compare how accurately the AI an…

This study aims to develop artificial intelligence tools to help doctors analyze capsule endoscopy videos. Capsule endoscopy involves swallowing a tiny camera that takes thousands of pictures of the digestive tract. The AI is designed to spot potential problems faster and more ac…

This is a very early safety study to test a potential new diagnostic tool called HB-2121 for celiac disease. Researchers will give a single dose to 18 adults (some with celiac disease, some healthy) and monitor them for 30 days to check for side effects and see how the body proce…

This study is testing whether adding a special remineralizing mousse to a daily hydroxyapatite toothpaste routine works better than the toothpaste alone. It aims to reduce tooth sensitivity and help repair weakened enamel in 40 adults with celiac disease. Researchers will measure…

This study is testing whether a special mobile app, backed by a support nurse, can help adults newly diagnosed with celiac disease feel better in their daily lives. For six months, half the participants will use the app for education and guidance on managing a strict gluten-free …

This study aims to understand how the immune systems of children with celiac disease react to very small, controlled amounts of gluten. About 45 children, who are already on a strict gluten-free diet, will take either a placebo or one of two small gluten doses for three days. Res…

This large study aims to screen 33,000 children for early warning signs of type 1 diabetes and celiac disease during their regular doctor visits. Researchers want to see if routine screening can help identify children at risk before they get seriously ill. Children who test posit…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study aims to understand what goes wrong in the immune system to cause chronic gut diseases like celiac disease and inflammatory bowel disease. Researchers will analyze blood and tissue samples from 200 adult participants to learn how immune cells become dysfunctional. The g…

This study aims to understand why celiac disease affects people so differently. Researchers will compare the genes, gut bacteria, and immune responses of 3500 people with celiac disease, dermatitis herpetiformis, and healthy volunteers. The goal is to find markers that can predic…

This study aims to understand why celiac disease symptoms and gut damage vary so much between people. Researchers will observe 220 adults, including some who eat gluten and some on a gluten-free diet, to see how their bodies react. The goal is to gather information that could lea…

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…