IMMUNE SYSTEM DISEASES

This study tests whether a stem cell transplant from a healthy donor can safely treat people with T-cell problems that cause immune system issues. Participants receive chemotherapy and antibody therapy before the transplant to prepare their body. The goal is to see if the new imm…

This early-phase study tests a new treatment for people with Hodgkin lymphoma or cutaneous T-cell lymphoma that has not responded to standard therapy or has returned. The treatment uses a patient's own immune cells (T cells) that are genetically modified to recognize and attack c…

This study was designed to test an experimental drug called HMPL-523 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding problems. The goal was to see if the drug is safe and can raise platelet counts. However, th…

This study tests a new treatment for people with a type of leukemia that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to better find and kill leukemia cells. A special safety switch is a…

This early-phase study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. The T-cells are engineered to recognize and attack cancer cells, but also include a safety switch that can be activated to reduce severe…

This study tests a new immunotherapy called PVX108 for children and teens with peanut allergy. The goal is to see if it safely helps them tolerate more peanut protein without a severe reaction. About 90 participants aged 4 to 17 will receive either PVX108 or a placebo over severa…

This early-phase study tests a new treatment for multiple myeloma that has returned or not responded to standard therapy. The treatment uses a patient's own immune cells (T cells) that are modified in the lab to recognize and attack myeloma cells. The main goal is to find the saf…

This study is testing a new cell therapy for people with Hodgkin's or Non-Hodgkin's lymphoma that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better target cancer, and then infuse them back. The main go…

This study collects medical information and biological samples from 32 cancer patients starting or restarting immunotherapy. The goal is to better understand why some patients develop immune-related side effects and how to manage them. Researchers hope this knowledge will improve…