New CAR T-Cell therapy targets Hard-to-Treat multiple myeloma
NCT ID NCT03672318
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase study tests a new treatment for multiple myeloma that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells (T cells) that are modified in the lab to recognize and attack cancer cells carrying a protein called CD138. The main goal is to find the safest dose and check for side effects in 25 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CAR138 T cells (a type of immune cell engineered to recognize and attack multiple myeloma cells)
What this could lead to
If successful, this could lead to a new treatment option for people with multiple myeloma that has not responded to other therapies.
What could go wrong
This is an early phase 1 trial with only 25 participants, so it is too small to prove effectiveness. The treatment may cause serious side effects like cytokine release syndrome or prolonged low blood counts.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Lineberger Comprehensive Cancer Center at University of North Carolina
Chapel Hill, North Carolina, 27599, United States