IMMUNE SYSTEM DISEASES

This study tests if a stem cell transplant can cure people with severe immune system diseases that haven't responded to standard treatments. Participants aged 4-69 will receive donor stem cells to rebuild their immune system. The goal is to see if the transplant can permanently f…

This study tests whether a stem cell transplant from a healthy donor can control peripheral T-cell lymphoma that has not responded to standard treatments. Participants receive antibody therapy or chemotherapy before the transplant to prepare their body, then stay in the hospital …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study is testing whether a stem cell transplant from a healthy donor can safely treat people with severe immune system problems. Participants (ages 4-75) receive chemotherapy and then donor stem cells, followed by a hospital stay and years of monitoring. The goal is to see i…

This study tests whether an online training and peer support platform (Support-t) helps teenagers with type 1 diabetes prepare for moving from pediatric to adult healthcare. About 200 teens aged 14-16 from four Quebec hospitals will either receive usual care or also get access to…

This study follows 200 people aged 12 and older with moderate-to-severe eczema who are starting a new prescription of abrocitinib. Researchers will track how well the drug controls symptoms like itching and rash over 12 months in real-world settings. The goal is to see if the imp…

This study is testing two different drug treatments to see if they can reduce harmful inflammation in people with severe immune system disorders, making them better prepared to receive a stem cell transplant. Researchers want to know if these treatments help the donated stem cell…

This study tests an online training and support platform designed to help adults with type 1 diabetes better manage their condition. About 322 participants will use the platform for 12 months, either through their usual clinic care or on their own. Researchers will measure change…

This study looks at why certain white blood cells (eosinophils) become overactive in people with allergies, parasitic infections, or rare immune conditions. Researchers will observe up to 800 participants aged 1 to 100, using blood tests, bone marrow samples, and other exams—but …

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow up to 600 patients and their relatives over time, using exams and genetic tests to understand the disease better. No new treatments …