T-cell immunodeficiency

This study tests whether a stem cell transplant can cure people with serious immune system disorders. Participants, aged 4 to 69, receive healthy donor stem cells to rebuild their immune system. The goal is to see if the transplant can permanently fix the immune defect and elimin…

This early-stage trial tests an experimental HIV vaccine called ICVAX in 22 adults with HIV who are stable on antiretroviral therapy (ART). The goal is to see if the vaccine is safe and can strengthen the body's immune response against HIV. Participants receive four injections ov…

This study looks at whether giving two doses of the HPV vaccine instead of three can protect women living with HIV just as well. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have not been vaccinated before. If two doses work, it could make HPV va…

This early-stage trial tests whether a new HIV vaccine combination is safe and can trigger an immune response. About 78 healthy adults will receive either the vaccine or a placebo. The study uses two different dosing schedules to see which works better.

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This study tests whether a stem cell transplant from a healthy donor can help people with severe primary immunodeficiencies. Participants aged 4 to 75 receive chemotherapy before the transplant to prepare their body. The goal is to see if the procedure is safe and can improve imm…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden HIV reservoirs that remain in the body. About 50 adults with well-controlled HIV will either continue their usual therapy or receive lenacapavir injections plus pills. Researchers…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This study follows 200 people with HIV who need a kidney transplant. Half will receive a kidney from a donor with HIV, half from a donor without HIV. Researchers track how many patients experience organ rejection or death over time to see if donor HIV status affects outcomes.

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study looks at how well a long-acting injectable HIV treatment works in people with HIV-1 subtype A6, a common type in Eastern Europe. Researchers will compare medical records from 250 adults in Poland, Germany, and the Czech Republic who have already received the shots. The…

This study tests whether a once-weekly combination of two experimental drugs (islatravir and ulonivirine) works as well as the standard daily three-drug pill Biktarvy for people newly diagnosed with HIV-1. About 570 adults who have never taken HIV medication will be randomly assi…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This study tests two drugs, PDS01ADC and M7824, that work with the immune system to fight Kaposi sarcoma (KS), a cancer often linked to HIV or organ transplants. The trial enrolls 80 adults with advanced KS that has not responded well to prior therapy. Participants receive PDS01A…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests a program called ARC that helps HIV clinics improve their work environment and reduce discrimination. Researchers will compare viral suppression and care retention in clinics using ARC versus standard care. The goal is to see if better clinic culture leads to bet…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management classes, and relationship skills training to help couples reduce alcohol use. Researchers wi…

This study tests a stem cell transplant for people with common variable immunodeficiency (CVID) and other immune disorders. The goal is to replace the faulty immune system with a healthy donor's stem cells. Participants are aged 5 to 40 and will receive a reduced-intensity transp…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a drug called abemaciclib, already used for breast cancer, in people with Kaposi sarcoma (KS), both with and without HIV. The goal is to find a safe dose and see if it can shrink KS tumors. About 111 adults will take the drug daily in 28-day cycles until their ca…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This study tests whether resmetirom, a drug already approved for another liver condition, can safely reduce liver fat in people with HIV who also have fatty liver disease (MASLD). About 120 adults with well-controlled HIV will take either resmetirom or a placebo daily for 24 week…

This study tests an HIV medicine called doravirine in children aged 4 weeks to under 12 years who weigh less than 45 kg. The goal is to see how the drug works in their bodies and if it is safe. About 84 children who are either new to treatment or already have the virus under cont…

This study tests a program to reduce stigma for women in Botswana who have both HIV and a serious mental illness. The program helps women challenge negative stereotypes and build coping skills after leaving a psychiatric hospital. Researchers will compare viral suppression rates …

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This early-stage study tests whether belimumab is safe for people with idiopathic CD4 lymphopenia (ICL), a rare condition causing low CD4 white blood cells and increased infection risk. About 20 adults aged 18-70 with ICL and autoantibodies will receive 8 doses of belimumab intra…

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This early-phase trial tests whether specially engineered immune cells (CAR-T cells) can control HIV in people who stop their regular antiretroviral drugs. 18 participants will receive a single infusion of their own modified cells, with some also getting a mild chemotherapy drug …

This study in South Africa tests whether peer support and long-acting injectable HIV medication help teens (ages 12-19) stay virally suppressed and keep up with care. 720 teens living with HIV will take part. The goal is to see if these approaches improve health and retention ove…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This Phase 2 trial tests whether baricitinib, an FDA-approved arthritis drug, can reduce the amount of HIV hiding in the central nervous system. 95 people with HIV on stable antiretroviral therapy will receive either baricitinib or a placebo for 10 weeks. Researchers will measure…

This study looks at thinking and mental health issues in people with Velocardiofacial, Williams, and Fragile X syndromes. Researchers will test how well medications like methylphenidate, fluoxetine, and risperidone improve these symptoms. The goal is to better understand and trea…

This study tests three approaches to help older adults with HIV become more physically active: one-on-one coaching, cognitive behavioral therapy to overcome barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit …

This pilot study tests whether adding the HIV drug efavirenz to a person's current antiretroviral therapy (ART) can kill cells that harbor hidden HIV. About 26 adults with HIV who have low but detectable virus levels despite good adherence will take efavirenz for 8 weeks. The goa…

This study tests different approaches to help people with HIV whose current medication (tenofovir, lamivudine, and dolutegravir, or TLD) is no longer working. It involves 648 adults and teens in Uganda and South Africa. The goal is to find the best strategy to get the virus under…

This study tests an experimental drug called NT-I7 in people with idiopathic CD4 lymphopenia (ICL), a condition where low CD4 immune cells lead to severe infections and other diseases. The goal is to see if NT-I7 can safely increase CD4 cell counts. About 60 adults aged 18–75 wil…

This study tests a mobile app called WiseApp along with a smart pill dispenser to help Spanish-speaking people with HIV take their medication regularly. About 248 participants from New York City and the Dominican Republic will use the app for 12 months. The goal is to see if the …

This study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to diffe…

This study tests a system that uses a special pill bottle to track when HIV medication is taken. If doses are missed, the system alerts a care team to help address problems like food or housing issues. The goal is to help 110 adults in Los Angeles stick to their HIV treatment and…

This study tests a program called SAVVY that helps young people with HIV choose their preferred antiretroviral therapy (ART) and overcome barriers to getting it. The program includes counseling and a decision-support tool. Researchers will enroll 288 participants to see if this a…

This study tests two ways to help Latino men with HIV take their medication regularly. One group gets text reminders, and the other gets texts plus online support from a navigator. The goal is to see which approach works better for keeping the virus under control. 250 men will pa…

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

This study is testing a mobile health app designed to help women living with HIV remember their medications, appointments, and prescription refills. The app also addresses barriers like stigma and mistrust of the medical system. Researchers will enroll 80 women to see if the app …

This pilot study tests a program where a clinical pharmacist talks with people with HIV about the risks of drinking alcohol (with or without cannabis) while taking multiple medications, especially those that affect the brain. The goal is to see if this approach can reduce falls a…

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese lose weight and improve metabolic health. Researchers will enroll 66 adults with HIV who are on a specific antiretroviral therapy and have a BMI over 30. Participants wil…

This study tests a program called ADELANTE for Latinos with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the health worker progra…

This study tests a proactive approach to help people living with HIV quit smoking. A pharmacist calls participants, offers counseling, and sends cessation medication unless they opt out. The goal is to see if this method works better than standard care. The trial involves 231 adu…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests whether two experimental antibodies (MGD014 and MGD020) are safe in people with HIV who are on standard antiretroviral therapy. Some participants also receive a drug called Vorinostat to help expose hidden HIV, or temporarily stop their regular HIV meds. The goal…

This study tests a new way to help people with HIV stick to their medication. Participants join an adherence club where they pick up 6 months of medicine at once and can get peer support. The goal is to see if this approach improves viral suppression and keeps people in care comp…

This program offers extra stem cells from a half-matched family donor to patients who are getting a cord blood transplant for serious blood cancers or immune disorders. The goal is to help the bone marrow recover more quickly while the cord blood cells take over permanently. It i…

This study tests whether adding the drug fostemsavir to standard HIV treatment can lower the risk of heart disease in people with well-controlled HIV. Researchers will compare heart imaging and blood tests between 150 adults who get the extra drug and those who don't. Participant…

This study is testing a program called Women SHINE, which uses online peer support sessions and group therapy to help women living with HIV who have experienced interpersonal violence. The goal is to see if this approach helps them take their HIV medication more consistently and …

This study compares nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics to standard doctor-led care in hospitals. About 2,944 people will take part across South Africa. The goal is to see if nurse-led care works just as well, is safe, and lowers costs for pa…

This study looks at whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive recipients. Researchers will follow 30 adults with HIV and end-stage kidney disease who receive a kidney from an HIV-positive donor. The goal is to learn more about pat…

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This study is testing a group-based support program to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro take their HIV medication consistently. The program includes four sessions that focus on building social support, self-confidence, and problem-solvin…

This study tests whether daily text reminders and small prize incentives can help people with HIV take their medication on time every day. Researchers will enroll 550 adults in Uganda who recently started HIV treatment. Participants will receive text messages linking pill-taking …

This study tests whether taking the antibiotic azithromycin can reduce deaths in adults with advanced HIV. Researchers will give either azithromycin or a placebo to 8,000 participants and track who dies over 24 weeks. The goal is to see if this simple, cheap drug can save lives i…

This study is testing a new blood test that looks for fetal cells in the mother's blood to detect genetic conditions like Down syndrome. The test will be compared to standard diagnostic methods such as amniocentesis or newborn testing. The study involves 1,000 pregnant individual…

This study tests whether measuring HIV drugs in hair can reliably show if patients are taking their medication as prescribed. Researchers will collect hair and blood samples from 30 HIV patients who are known to be compliant. The goal is to see if hair can be a simple, non-invasi…

This study aims to see if a dried blood spot test can effectively screen drug users for hepatitis B, hepatitis C, and AIDS. Researchers will enroll 500 former or active drug users. The goal is to find a simpler way to detect these infections in a hard-to-reach population.

This phase 3 trial tests MK-8527, a once-monthly oral pill, to prevent HIV-1 infection in women. About 4580 HIV-negative women will take either MK-8527 monthly or a daily PrEP pill (Truvada) to see which works better and is safer. The goal is to offer a more convenient prevention…

This large phase 3 trial is testing whether a new oral pill called MK-8527, taken just once a month, can prevent HIV infection as well as the standard daily PrEP pill. About 4,390 people at risk of HIV will be randomly assigned to receive either the monthly pill or daily Truvada …

This study tests a program called SAKHI HPV for women in India who have both HPV and HIV. The program provides support from community health workers, group sessions, and nutrition education to help women stay healthy and reduce their risk of cervical cancer. Researchers will comp…

This study tests whether a mobile app plus virtual peer support can help young men who have sex with men (ages 16–25) start and stick with PrEP, a daily pill that prevents HIV. The app provides sexual health information and connects users with a peer navigator who can guide them …

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study combines peer navigation (trained community members) with mobile health tools to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be split into two groups: one g…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study tests a program called PrEP My Way that helps young women aged 16-24 in Kisumu, Kenya stay on HIV prevention medication. Participants can choose between a daily pill, a long-acting shot, or a vaginal ring, plus get support from peers. The goal is to see if offering cho…

This study tests a program to help Latinx men lower their HIV risk by combining easy access to PrEP medication, social support from friends, and a national pharmacy chain. Researchers will enroll 624 men aged 18-54 and track how many start and stick with PrEP. The goal is to crea…

This study tests whether a mobile app called MyPEEPS can reduce new HIV infections among 3,200 high-risk young men who have sex with men and non-binary individuals aged 16-29. Participants use the app to learn safer sex strategies and are compared to a standard care group. The tr…

This study tests a peer-led program that helps women at risk of HIV choose and stick with prevention methods like PrEP. About 60 HIV-negative women in Uganda will get support from trained peers to pick what works best for them. The goal is to see if this approach increases use of…

This study tests whether a health coach can help people leaving jail learn about and get PrEP, a daily pill that prevents HIV. The coach will be part of a re-entry program in Dallas. Researchers will see if this approach is feasible and acceptable to clients and staff.

This study is checking the long-term safety and effectiveness of a long-acting injectable drug called cabotegravir (CAB LA) for preventing HIV. It includes about 3,500 people who already received CAB LA in earlier HIV prevention studies. Participants will continue getting the sho…

This early-stage study tests a new long-acting injectable drug, VH4011499, in 168 healthy adults without HIV. The goal is to see if it is safe and how the body processes it, as a potential future option for HIV prevention. Participants receive one or more doses of the drug or a p…

This study looks at whether giving HIV prevention pills (PrEP) at the same time as opioid addiction treatment in pharmacies is practical and acceptable. About 350 HIV-negative adults on opioid therapy in Alberta and Saskatchewan will take part. Researchers will track how many peo…

This study tests a peer-led community program to help Black men in Prince George's County, Maryland, start taking PrEP, a daily pill that prevents HIV. The program uses in-person events to reduce stigma, build social support, and teach skills for getting HIV care. Researchers wil…

This study tests whether a brief alcohol counseling program helps high-risk adults who drink heavily stay on HIV prevention medication (PrEP or PEP). Researchers will enroll 400 people at drinking venues in Kenya and Uganda, giving half the counseling and half standard care. They…

This study tests two types of smell training in 80 adults aged 40+ with HIV. Participants will sniff scents at home twice a day for 8 weeks. The goal is to see if the training is easy to do and if it improves smell and thinking abilities.

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This pilot study is testing whether chiropractic care can improve quality of life and reduce inflammation in adults with HIV. Researchers will compare a group receiving weekly chiropractic adjustments to a group receiving no treatment. The study aims to see if a larger trial is p…

This study tests whether a low dose of naltrexone, a drug normally used for addiction, can safely reduce chronic nerve pain in people with HIV. About 60 adults with HIV and nerve pain will take the drug for 12 weeks and report their pain levels. The goal is to find a cheaper, non…

This study tests whether an AI-powered therapy program can help older adults (50+) living with HIV who are at risk for suicide. Participants watch short videos teaching coping skills and can chat with a coach. The goal is to see if this approach is practical and helps people mana…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study tests whether doing tai chi/qigong over Zoom twice a week for 12 weeks can reduce depressive symptoms in people aged 50-75 living with HIV. About 326 participants will be randomly assigned to either tai chi or a health education class. Researchers will track mood, hear…

This early-phase study will give 9 healthy adults a single dose of the experimental HIV drug VH4524184, plus a tiny radioactive version to track it. Researchers will measure how much of the drug gets into the blood, how it's broken down, and how it leaves the body through urine a…

This study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…

This study aims to understand how HIV behaves differently in the blood compared to lymph nodes and bone marrow. Researchers will take samples from 400 people living with HIV and some without HIV to measure virus levels and immune system changes. The goal is to learn more about wh…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study follows a large group of people with HIV over many years to track their health, treatments, and any complications. Researchers will collect medical data during regular clinic visits to better understand how the disease and its treatments affect patients over time. The …

This study tests whether giving clinics a dedicated coach helps them offer alcohol treatment to people with HIV who drink too much. The coach provides tools and guidance to support a stepped care model, which starts with brief advice and progresses to therapy or medication if nee…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study reviews medical records of over 5,600 people with HIV to see how many might need special dental care due to low immune cells or blood issues. The goal is to help dentists know when to take extra steps and when standard care is safe, reducing stigma. It is an observatio…

This study in South Africa works with women who have HIV and abnormal Pap results to find out why some don't follow up for cervical cancer care. Researchers will interview patients and providers, then create a short counseling and navigation program. They will test if the program…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study looks at people with HIV who are 75 or older and take at least five medications regularly. Researchers want to understand how this 'polypharmacy' affects healthy aging and quality of life. They will interview participants and review their medical records to count medic…

This study aims to understand where HIV hides in the body when people stop their daily antiretroviral therapy (ART) for a short time. Fifty adults with HIV will either stay on ART or pause it for up to 90 days. Researchers will use PET/CT scans and take small tissue samples from …

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study tracks the health of people with HIV over time to learn more about the infection and related conditions. It is for adults 18 and older in the Washington, D.C., area who have or may have HIV. Participants visit the clinic every few months for check-ups and blood tests, …

This study aims to collect stem cells from people with a rare condition called idiopathic CD4 lymphocytopenia (ICL) and from healthy volunteers. Participants receive two medications to move stem cells from bone marrow into the blood, where they are collected. The stem cells are t…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study will screen 2,000 people with HIV for fatty liver disease using a painless ultrasound technique. The goal is to catch liver problems early and improve long-term care. Researchers will also track how different HIV medications affect liver health.

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at whether being more forgiving and holding less resentment can improve quality of life for people living with HIV. Researchers will follow 206 participants at a French hospital, measuring their tendency to forgive and their well-being. The goal is to see if forg…

This study in Zambia will follow about 11,800 people with advanced HIV who are starting or restarting antiretroviral therapy (ART). Researchers want to learn who these patients are, what challenges they face, and how well they do in the first six months of treatment. The goal is …

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study looks at how well vaccines against respiratory viruses (like flu or COVID-19) work in people with weakened immune systems, including those with blood cancers. Researchers will measure both antibody and T cell responses after vaccination. The goal is to understand why v…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study looks at whether stopping vaginal washing can lower inflammation in the cervix, which might help explain why this practice is linked to a higher risk of HIV. Researchers will measure immune cells and protective bacteria in 122 women who currently wash inside the vagina…

This study looks at the bacteria living in the lungs of people with active tuberculosis (TB) and how they change with treatment. Researchers will compare lung bacteria in diseased and healthy areas, and also check the mouth, nose, and gut. They aim to understand how these microbe…

This study looks at immune cells in the gut, spinal fluid, lymph nodes, and blood of HIV-positive and HIV-negative adults in Thailand. The goal is to understand how HIV changes the immune system in different parts of the body. About 232 people aged 18 to 50 will join. No new trea…

This study looks at how harm reduction care (a non-judgmental approach to drug use) in HIV clinics affects stigma and health outcomes for people living with HIV who use drugs. Researchers will survey 768 patients and providers to understand how attitudes and care practices influe…

This study tests a program called TransAction to help transgender women in Ho Chi Minh City improve their HIV prevention and care. 80 participants will either join the full program (individual sessions, group support, and social events) or just social events. The goal is to see i…

This study gathers basic health information from 2000 people receiving stem cell transplants for blood cancers or immune disorders. The goal is to track survival and complications to help doctors and researchers improve future treatments. Participants must be getting a standard t…

This study tests whether a very brief, persuasive message—delivered by a video or a counselor—can increase HIV and hepatitis C testing among emergency room patients who initially said no. About 2,000 adults who speak English or Spanish and haven't been tested in the past year wil…

This study follows 150 adults with advanced HIV who are hospitalized in South Africa. Researchers will interview them and review medical records to see if they successfully continue HIV care after leaving the hospital. The goal is to identify where the system fails and find ways …

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study aims to understand frailty in people with HIV who are 50 or older. Researchers will screen participants for signs of weakness or low stamina, then offer a personalized activity plan with strength, balance, and walking goals. The study will track how well people stick w…

This study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at whether long-acting antiretroviral drugs for HIV prevention (PrEP) are effective and affordable for key populations in Thailand, including men who have sex with men and transgender women. Researchers will survey over 10,000 people about their preferences, anal…

This study looks at whether traditional healers in rural Uganda can offer HIV screening tests to children aged 18 months to 5 years. Researchers will compare how many caregivers accept testing from a healer versus how many follow a referral to a health center. The goal is to find…

This study is testing whether setting up special HIV teams in hospitals can increase testing for undiagnosed HIV. The teams will remind doctors to test patients with certain health conditions, reduce stigma, and improve care links. Over 5,200 patients across ten European countrie…

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex and are HIV-negative or don't know their status will receive either helpful texts or general information. Researchers will check if more teens ge…

This study is a long-term project that collects health information from 30,000 HIV patients at 15 clinics in France. The goal is to track how well HIV treatments are working, monitor changes in the disease over time, and understand related health issues like hepatitis C. No new t…

This study compares fat storage around the heart and liver in people with HIV versus the general population using MRI scans. Researchers aim to understand why HIV-positive individuals have double the risk of heart attacks. The study involves 100 participants aged 40 and older wit…

This study looks at how adults in France choose to get tested for HIV voluntarily. Researchers will survey 1,000 people aged 18 and older to see which testing methods they use, such as doctor prescriptions, free testing centers, or self-tests. The goal is to learn more about test…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This long-term study follows 19,000 people with or at risk for HIV in Washington, DC to track their health outcomes and quality of care. Researchers will monitor viral suppression rates and new infections over up to 10 years. The goal is to find ways to improve HIV treatment and …

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study will offer HIV tests to everyone visiting emergency departments in South Africa and Baltimore, regardless of risk factors. The goal is to find undiagnosed HIV cases and connect people to either treatment or preventive medication (PrEP). Researchers will track how many …

This study pauses HIV medication in 40 volunteers to closely monitor how the virus and body interact during the earliest stages of rebound. Participants stop their antiretroviral therapy and undergo frequent testing, resuming treatment within three weeks. The goal is to learn mor…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study tests whether having traditional healers offer HIV counseling and testing can increase the number of people who get tested compared to usual care. Over 230,000 adults in rural South Africa will take part. The goal is to reach people who might avoid regular clinics and …

This study looks at whether giving out special syringes with less leftover space (low dead-space) can help reduce the spread of HIV and hepatitis among people who inject drugs. Researchers will talk with participants and track their health in several countries. The goal is to fin…

This study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using b…