Botox for leg pain? new trial tests a surprising treatment
NCT ID NCT05765071
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether injecting Botox into leg muscles can reduce pain during exercise in people with chronic exertional compartment syndrome (CECS). Fifty adults with confirmed CECS will receive either Botox or a placebo injection. Researchers will track pain levels and leg function over 24 weeks to see if the treatment helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Botulinum toxin A (Botox)
What this could lead to
If it works, this could offer a non-surgical option to reduce leg pain during exercise for people with chronic exertional compartment syndrome.
What could go wrong
This is a small pilot study with only 50 participants, so results may not apply to everyone. The treatment is temporary and may not work better than placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Calgary Sport Medicine Centre
RECRUITINGCalgary, Alberta, T2N 1N4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact