Botox for leg pain? new trial tests a surprising treatment
NCT ID NCT05765071
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether injecting Botox into leg muscles can reduce pain during exercise in people with chronic exertional compartment syndrome (CECS). Fifty adults with confirmed CECS will receive either Botox or a placebo injection. Researchers will track pain levels and leg function over 24 weeks to see if the treatment helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Botulinum toxin A (Botox)
- What this could lead to
- If it works, this could offer a non-surgical option to reduce leg pain during exercise for people with chronic exertional compartment syndrome.
- What could go wrong
- This is a small pilot study with only 50 participants, so results may not apply to everyone. The treatment is temporary and may not work better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Calgary Sport Medicine Centre
RECRUITINGCalgary, Alberta, T2N 1N4, Canada
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Other studies related to the condition(s) this trial covers.