Could POTS be an autoimmune disease? new study tests nerve stimulation as a treatment

NCT ID NCT05043051

Completed Knowledge-focused Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study looks at whether postural tachycardia syndrome (POTS) is caused by an autoimmune reaction. Researchers are testing if electrical stimulation of the vagus nerve can improve symptoms, reduce inflammation, and calm the immune system. The study includes 80 people with POTS and healthy volunteers to better understand the condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vagal stimulation (transcutaneous electrical nerve stimulation)
What this could lead to: If successful, this could point toward a new treatment for POTS by targeting the immune system and using nerve stimulation to reduce symptoms.
What could go wrong: This is an early-stage study focused on understanding the cause of POTS, not a treatment trial. The nerve stimulation approach may not work for everyone, and results may not lead to a proven therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTURAL TACHYCARDIA SYNDROME

Contacts and locations

Locations

Oklahoma Clinical and Translational Science Institute

Oklahoma City, Oklahoma, 73104, United States

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