Could POTS be an autoimmune disease? new study tests nerve stimulation as a treatment
NCT ID NCT05043051
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether postural tachycardia syndrome (POTS) is caused by an autoimmune reaction. Researchers are testing if electrical stimulation of the vagus nerve can improve symptoms, reduce inflammation, and calm the immune system. The study includes 80 people with POTS and healthy volunteers to better understand the condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vagal stimulation (transcutaneous electrical nerve stimulation)
What this could lead to
If successful, this could point toward a new treatment for POTS by targeting the immune system and using nerve stimulation to reduce symptoms.
What could go wrong
This is an early-stage study focused on understanding the cause of POTS, not a treatment trial. The nerve stimulation approach may not work for everyone, and results may not lead to a proven therapy.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Oklahoma Clinical and Translational Science Institute
Oklahoma City, Oklahoma, 73104, United States