Autonomic nervous system disorder

This study tests a new radioactive drug, [212Pb]VMT-alpha-NET, in people with advanced gastrointestinal neuroendocrine tumors or pheochromocytoma/paragangliomas that have already been treated with radiation therapy. The drug is designed to attach to a protein on the surface of th…

This phase 2 study tests belzutifan, a daily pill that blocks a protein called HIF-2α, in people with advanced rare cancers like pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, VHL disease-associated tumors, and certain other solid tumors. The goal is to see if …

This early-phase trial tests a new drug called ADCT-701 in adults with rare cancers like neuroendocrine tumors, adrenal cancer, and malignant peripheral nerve sheath tumors. The goal is to find the safest dose and see if it can shrink tumors or slow disease. Participants receive …

This early-stage trial tests a radioactive drug that seeks out and delivers radiation directly to cancer cells with a specific protein (somatostatin receptor). It is for adults with advanced lung, kidney, head and neck, digestive tract, or adrenal gland tumors that cannot be remo…

This phase 2 trial is testing a drug called ONC206 in 90 people with advanced pheochromocytoma or paraganglioma, rare tumors of the adrenal glands. Participants must have tumors that cannot be removed by surgery and have not responded to or cannot have standard treatments. The st…

This study is testing a combination of two drugs—a targeted radioactive drug (177Lu-DOTATATE) and a PARP inhibitor (olaparib)—in children and teens aged 3 to 18 with certain solid tumors that have come back or not responded to treatment. The goal is to see if the combination is s…

This study tests a radioactive drug called I-MIBG in people with resistant neuroblastoma or related tumors (pheochromocytoma and paraganglioma). The drug is designed to deliver radiation directly to cancer cells. Researchers want to see if it can shrink tumors and how safe it is.…

This study tests a new drug called [212Pb]VMT-α-NET, which delivers a powerful type of radiation (alpha particles) directly to tumor cells that have a specific marker (SSTR2). The trial includes 300 adults with advanced neuroendocrine tumors or meningioma that cannot be removed b…

This study tests whether the drug landiolol can safely keep heart rate below 90 beats per minute during major surgery in 114 patients with heart risks. The goal is to see if this approach is feasible and might reduce heart injury after surgery. Participants receive the drug throu…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This phase 2 trial tests a radioactive drug called Lu-177-DOTATATE in 130 adults with rare adrenal or neck tumors that cannot be surgically removed. The drug is given four times over about 8 months, and researchers track how long the cancer stays under control. The goal is to see…

This study tests an experimental drug called ALN-SNCA in 46 people with early Parkinson's disease. The drug is designed to lower levels of a harmful protein, alpha-synuclein, in the brain. The main goal is to check if the drug is safe and tolerable, and to see how it moves throug…

This expanded access program provides 131 I-MIBG therapy for children and young adults with refractory or relapsed neuroblastoma, a cancer that hasn't responded to standard treatments. The therapy uses a radioactive compound that is taken up by cancer cells, delivering radiation …

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study tests whether an implanted spinal cord stimulator can improve autonomic functions like blood pressure and heart rate in people with chronic cervical spinal cord injury. The device delivers electrical pulses to the spinal cord to help regulate involuntary body processes…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…

This study tests a procedure called cardioneuroablation for people with a slow heart rate (bradycardia) caused by overactive vagal nerves. Doctors use a catheter to ablate (destroy) specific nerve clusters in the heart. The trial will enroll 188 participants aged 18-65 and measur…

This study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans and adults in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab…

This study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…

This early study tests a spinal cord stimulation therapy called ARC-IM in 5 people with Parkinson's disease or related conditions who experience severe drops in blood pressure when standing (orthostatic hypotension). The main goal is to check safety, and researchers will also mea…

This study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dy…

This study tests the drug belzutifan in 100 people with von Hippel-Lindau (VHL) syndrome, a genetic condition that causes tumors in various organs. Researchers will track how well the drug shrinks tumors and how long it takes for the disease to progress, while also monitoring sid…

This study tests whether a new imaging agent called [18F]FAPI-74 can find certain cancers as well as or better than the standard PET tracer. About 320 adults with one of 11 cancer types (including pancreatic, liver, ovarian, and lung cancers) will receive both tracers and have th…

This study tests a new radioactive imaging agent called 68Ga-HA-DOTATATE to see if it can safely and accurately detect neuroendocrine tumors using PET/CT scans. About 600 people with known or suspected tumors will receive the agent and be followed for one year. The goal is to imp…

This study tests a newer type of PET/CT scan (Al18F-NOTA-LM3) against the current standard (68Ga-DOTATATE) to see which finds more tumors in people with pheochromocytoma or paraganglioma (PPGL). About 40 adults with suspected or confirmed PPGL will receive both scans, and doctors…

This study tests whether a special PET/MRI scan using a radioactive tracer called Ga68-DOTATATE can better detect certain brain tumors (like meningioma) and tell them apart from changes caused by past treatments. About 200 adults with these tumors will get the scan alongside stan…

This study is testing whether special PET scans using targeted tracers can accurately find and stage neuroblastoma and pheochromocytoma/paraganglioma tumors. About 30 people aged 1 to 70 will receive an injection of a radioactive tracer and then have a PET scan. The scan results …

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can improve heart rate variability and quality of life in people who have had a stroke. 44 participants will receive either real or sham rTMS for 4 weeks. The goal is to see if this brain stimulation can…

This study tests if a nerve block injection in the neck can reduce long-COVID symptoms like fatigue, brain fog, and heart palpitations. About 78 adults with post-COVID condition will get either the real block or a fake injection to see if it helps. The goal is to find a safe, eff…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study tests whether a structured exercise program can improve heart rate variability (a measure of heart health), reduce menopausal symptoms, and enhance sleep and quality of life in postmenopausal women aged 45 to 65. Forty women will either join a supervised 12-week exerci…

This study looks at whether a simple device that makes you breathe in a little extra carbon dioxide (CO2) can help raise blood pressure in people with a condition called neurogenic orthostatic hypotension (nOH). People with nOH get dizzy or even faint when they stand up because t…

This study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…

This study tests a device called Cereset Research to see if it can improve how the body handles stress, anxiety, and insomnia. About 200 adults with these symptoms will use the device while researchers measure heart rate and blood pressure changes. The goal is to find a non-drug …

This study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…

This study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study is testing whether a small, battery-powered device worn on the ear can reduce gastrointestinal symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related autonomic nervous system problems. The device, called IB-Stim, delivers gentle elec…

This study tests whether Northera (droxidopa) is safe and can improve symptoms like dizziness, fainting, and low blood pressure in children aged 7 to 17 with Menkes disease. Six to ten participants will receive either the drug or a placebo in two four-week periods, with careful d…

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime hypertensi…

This study tests whether a non-invasive spinal cord stimulation device can improve autonomic functions like blood pressure, bladder, bowel, and sexual control in people with chronic spinal cord injury. Thirty participants will receive targeted stimulation over several weeks. The …

This study looks at whether raising the head of the bed can help lower high blood pressure that happens when people with autonomic failure lie down. About 44 adults aged 18-85 with this condition will be studied overnight. The goal is to see if gravity reducing blood return to th…

This study looks at whether using a CPAP machine at night can lower dangerously high blood pressure that happens when people with autonomic failure lie down. About 12 participants will use CPAP or a placebo pill/patch. The main goal is to see if CPAP reduces blood pressure while …

This study tests whether special breathing exercises can help veterans and others with persistent post-concussion symptoms like headaches, dizziness, and memory trouble. The exercises aim to improve heart rate variability, a sign of how well the nervous system is working. 148 par…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

This study explores whether a small accelerometer worn on the thigh can objectively measure how well treatments work for neurogenic orthostatic hypotension—a condition causing dizziness and fainting upon standing. Participants wear the device for one week on placebo and one week …

This pilot study looks at how belzutifan, a drug already used for some tumors, changes the production of adrenaline-like hormones in people with pheochromocytoma and paraganglioma (PPGL). Over 5 days, researchers measure key substances in the hormone-making process to see if belz…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study aims to improve how doctors find and understand pheochromocytomas and paragangliomas, rare tumors that can cause dangerous high blood pressure. Researchers will use advanced imaging scans and genetic testing in up to 3,000 participants to learn more about these tumors.…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study from Mayo Clinic looks at how multiple sclerosis (MS) affects the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers will compare 13 people with MS to healthy volunteers using simple lab tests. The goal…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-tabl…

This study looks at how the autonomic nervous system—which controls heart rate and blood pressure—works in people with Down syndrome. Researchers will measure stress responses using virtual reality, cold water, pain patches, caffeine, and exercise in 200 participants. The goal is…

This study is a large registry that collects health information and leftover tumor or blood samples from up to 75,000 children and young adults with cancer. The goal is to track outcomes and gather data to help doctors find better ways to treat and care for these patients over ti…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study looks at how the autonomic nervous system (which controls automatic body functions) might be involved in liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis to find new ways to detect liver cancer earlier. The goa…

This study aims to bring molecular markers into routine care for patients with rare adrenal cancers. Researchers will collect blood, urine, and tumor samples from 450 patients before and after surgery to see if these markers can guide treatment decisions. The goal is to make thes…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the link betwee…

This study looks at how the body controls blood pressure and heart rate in healthy young adults and older adults with high blood pressure. Participants will do tests like standing up and cycling while their heart and blood vessels are monitored. The goal is to better understand t…

This study looks at whether doing jaw stretches and a specific breathing pattern (4-4-8) can affect stress levels, muscle tightness, and mood. About 52 healthy university students will be randomly assigned to do these exercises. Researchers will measure heart rate, blood pressure…

This study uses a special PET scan with a radioactive tracer called [18F]F-DOPA to measure dopamine production in the brains of people with autonomic failure (problems with automatic body functions like blood pressure). The goal is to see if changes in dopamine levels can predict…

This study from the University of Florida is looking at how listening to calming music might affect your health and sense of calm. About 100 participants will listen to a 15-minute music session, fill out surveys, and some will also have their heart rate monitored and give saliva…

This study gathers medical information from 200 adults with possible nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Participants undergo standard tests like nerve conduction studies, EMG, and physical exams. The data is stored anony…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This early-phase study is testing an investigational radioactive tracer called 18F-FluorThanatrace (FTT) for PET/CT scans in up to 30 people with pheochromocytoma or paraganglioma—rare tumors of the adrenal glands or nerve tissue. The tracer aims to measure a protein called PARP-…

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study explores whether high-intensity interval training (HIIT) is a feasible and acceptable option for people with long-term shoulder pain, such as rotator cuff issues or frozen shoulder. Researchers will enroll 15 people with shoulder pain and 15 without, measuring inflamma…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents and children dealing with anxiety, depression, and stress. About 80 parents of children aged 2-7 will complete surveys and provide saliva samples to measure oxytocin levels. The goal is to unders…

This study looks at why people with COPD may have overactive nerve signals that increase heart rate and narrow blood vessels. Researchers will measure nerve activity, breathing, and inflammation in 135 adults with COPD. The goal is to better understand the causes, not to test a n…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at how fast the bladder is filled during a urodynamic test affects a condition called autonomic dysreflexia (sudden high blood pressure) in people with spinal cord injuries. Researchers will test two different filling speeds in 30 participants to see which one ca…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study looks at a mobile workshop called Breizh Fabribus that uses 3D printing and laser cutting to make custom assistive devices on the spot for people with disabilities in a region of France. Researchers will track 70 people who received a device to see if it helps them do …

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This study is looking at children ages 7 to 18 who have been newly diagnosed with high blood pressure. Researchers want to understand how certain hormones in the body, like angiotensin-(1-7), may contribute to damage in the heart, kidneys, and blood vessels. Over two years, they …

This study looks at whether a blood test for a protein called p-tau181 and brain scans can predict which elderly patients with dementia, frailty, and loss of independence will need to visit the emergency room within six months. Researchers will follow 110 participants and track E…

This small pilot study aims to see if a new in-ear wearable device can comfortably and reliably measure blood flow changes in the head. Researchers will compare people who have low blood sugar after bariatric surgery to those who don't. The goal is to learn if this device can hel…

This study looks at how blood flow and the nervous system adapt early in aging women. Researchers will measure forearm blood flow in 64 women aged 18-70. The goal is to better understand these changes, not to test a treatment.

This study looks at children with ROHHAD syndrome, a rare condition that causes rapid weight gain and breathing problems. Researchers will take blood samples to create special cells in the lab and study their genetic activity. The goal is to understand what goes wrong in the body…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic changes that cause these tumors and how they affect health. Up to 2,000 patients and their family members will provide DNA sampl…

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy or Parkinson's disease will participate.…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …

This study looks at whether a type of brain stimulation called rTMS, combined with letting people choose when to get feedback, can improve how healthy young adults learn a motor task. 72 participants will be split into groups receiving different types of stimulation or a fake ver…