Autonomic nervous system disorder

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested different treatments for autonomic dysfunction, including POTS, in 381 adults with Long COVID. It compared non-drug approaches and medications to see which best eased symptoms like rapid heart rate and dizziness. The goal was to find effective ways to manage the…

This study looked at whether a new blood marker called EM66 can help doctors tell the difference between high blood pressure caused by rare adrenal tumors (pheochromocytoma or paraganglioma) and regular high blood pressure. Researchers measured EM66 levels in 60 adults with eithe…

This study looked at whether a 15-minute hand soak in warm water can help diagnose small fiber neuropathy, a condition that causes pain, numbness, and problems with automatic body functions. Researchers tested 38 adults and compared the wrinkling pattern of their fingertips to st…

This study looked at whether a 16-week brisk walking program, combined with dietary advice, could improve heart rate control and blood vessel health in adults with early-stage cirrhosis (liver scarring). Fifty participants aged 45-75 who were not very active took part. The goal w…

This study tested an automated abdominal binder that inflates when a person stands, applying pressure to help maintain blood pressure. It included 28 adults with autonomic failure and disabling orthostatic hypotension. Participants wore either the active binder or a sham version …

This study tested whether the drug Northera (droxidopa) is safe and helpful for adults with Menkes disease or Occipital Horn Syndrome who have trouble with low blood pressure and other symptoms of dysautonomia. Three participants took either the drug or a placebo in a crossover d…

This pilot study tested whether a 12-week aquatic occupational therapy program could reduce symptoms and improve quality of life in people with Postural Orthostatic Tachycardia Syndrome (POTS). Five adults with POTS completed three 60-minute pool sessions per week, including gent…

This study gave a radioactive drug called 131I-MIBG to 15 people with advanced nerve tumors (neuroblastoma or pheochromocytoma) that had stopped responding to standard treatments. The goal was to see if it could ease symptoms and shrink tumors, while tracking side effects. Partic…

This study tested a device that gently stimulates a nerve in the neck (called nVNS) to see if it can reduce symptoms like dizziness and fatigue in teenagers with POTS, a condition that causes a rapid heart rate upon standing. Forty teens with newly diagnosed POTS took part at May…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This pilot study explored whether the Feldenkrais Method, a gentle movement and awareness practice, could reduce stress and improve well-being in 24 healthy, sedentary women aged 26-59. Participants attended eight daily 90-minute sessions or served as controls. Researchers measur…

This study tested a device called Cereset Research that plays tones in response to a person's brainwaves, aiming to reduce stress and improve sleep. 94 stressed healthcare workers used the device for several sessions and were followed for a year. The goal was to see if the device…

This study looks at how the body's stress (sympathetic) nervous system changes after 8 weeks of either strength training alone or strength training combined with running. Researchers measure nerve activity, muscle strength, and jumping ability in healthy young men who have not ex…

This study tested whether taking hot spring baths (38°C for 20 minutes, three times a week) helps healthy teen athletes adapt to training at 1600 meters altitude. 27 participants were split into three groups: hot spring baths, hot water baths, or standard recovery. Researchers me…

This study looked at whether nerve signals (called sympathetic skin response) are linked to how well women respond to standard lymphedema therapy after breast cancer surgery. Thirty women with lymphedema and thirty healthy women had nerve tests and filled out symptom questionnair…

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…

This study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This study looked at 22 adults with spinal cord injury to understand whether anxiety or physical discomfort causes changes in heart rate and blood pressure during bladder catheterization. Participants either did the procedure themselves or had a nurse do it, with some not knowing…

This study looked at how two simple techniques—special breathing and changing body position—affect the nervous system in healthy young adults. 27 people aged 18-25 took part. The goal was to measure changes in heart rate, blood pressure, and nerve activity, not to treat any disea…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…

This completed study examined whether fibromyalgia, a condition causing widespread pain, is linked to changes in eye blood vessels. Researchers compared 80 people with and without fibromyalgia using eye scans and symptom questionnaires. The goal was to see if nerve system problem…

This study looked at whether people with fibromyalgia have early, hidden changes in heart function. Researchers used a special ultrasound technique called Global Longitudinal Strain (GLS) to measure heart muscle movement in 59 fibromyalgia patients and 59 healthy volunteers. The …

This study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…

This study looked at 10 men to understand why androgen deprivation therapy (ADT) for prostate cancer can lead to high blood pressure. Researchers checked if problems with the nervous system or kidneys were to blame. The goal is to find ways to prevent heart disease in prostate ca…

This study created a new imaging-based grading system to help doctors predict how complex and risky surgery will be for patients with rare adrenal and nerve tumors called PPGL. Researchers used 3D scans from 500 patients to develop the system, aiming to improve surgical planning …

This study looked at whether a patient's abdominal circumference (belly size) is linked to how long surgery takes to remove a pheochromocytoma, a rare adrenal tumor. Researchers reviewed records of 159 adults who had the surgery. The goal was to see if belly size could help docto…

This study tested whether the ACCUVEIN, a device that projects veins onto the skin, can detect changes in vein size caused by the nervous system. Researchers had 12 healthy adults lie on a tilt table and slowly move from lying flat to standing upright. They used the device to see…

This study looked at whether people with long-term neck pain have differences in their autonomic nervous system (the part that controls things like heart rate) compared to healthy people. Researchers measured heart rate variability in 56 participants while lying down, sitting, st…

This completed study looked at whether stimulating a nerve in the ear (vagus nerve) or doing controlled breathing exercises can improve physical performance and affect the nervous system. 64 healthy, moderately active men took part. The goal was to see how these two approaches co…

This study looked at how stress changes the way your nervous system controls your heart rate. Researchers gave 23 healthy adults a hormone called cosyntropin or a placebo to see if it caused delayed changes in heart rate control. The goal was to understand the link between stress…

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, such as family history, loss of smell, blood pressure drops, or a sleep disorder. Participants underwent brain scans, spinal taps, and other tests over several y…

This early-phase study looked at whether xenon gas, used as anesthesia, changes the nerve signals that control muscles and blood pressure. Eight healthy volunteers received xenon gas for 30 minutes while researchers measured nerve activity, heart rate, and blood chemicals. The go…

This study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise…