Autonomic dysreflexia
MONDO:0043975A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)
Also known as: autonomic dysreflexia, Dysreflexia, autonomic, Dysreflexia, spinal autonomic, Dysreflexias, autonomic, Dysreflexias, spinal autonomic, autonomic Dysreflexia, spinal, autonomic Dysreflexias, autonomic Dysreflexias, spinal
11 clinical trials for this condition and its sub-types.
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Could controlled Low-Oxygen breathing prevent dangerous blood pressure swings in spinal injury?
Disease control Recruiting nowThis study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dy…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Spinal stimulation may steady blood pressure in paralyzed patients
Symptom relief Recruiting nowThis study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…
Phase: NA • Sponsor: University of Louisville • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Spinal stimulation offers new hope for autonomic recovery after injury
Symptom relief Recruiting nowThis study tests whether a non-invasive spinal cord stimulation device can improve autonomic functions like blood pressure, bladder, bowel, and sexual control in people with chronic spinal cord injury. Thirty participants will receive targeted stimulation over several weeks. The …
Phase: NA • Sponsor: University of British Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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MS study aims to unlock secrets of Body's 'Autopilot' system
Knowledge-focused Recruiting nowThis study from Mayo Clinic looks at how multiple sclerosis (MS) affects the autonomic nervous system, which controls things like blood pressure, skin blood flow, and bladder health. Researchers will compare 13 people with MS to healthy volunteers using simple lab tests. The goal…
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Smartwatches and nerve tests aim to unlock spinal injury secrets
Knowledge-focused Recruiting nowThis Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Bladder test speed may trigger dangerous blood pressure spikes in spinal injury patients
Knowledge-focused Recruiting nowThis study looks at how fast the bladder is filled during a urodynamic test affects a condition called autonomic dysreflexia (sudden high blood pressure) in people with spinal cord injuries. Researchers will test two different filling speeds in 30 participants to see which one ca…
Sponsor: Pusan National University Yangsan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC