New hope for rare adrenal cancer: drug trial launches

NCT ID NCT07282587

Recruiting now Disease control Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a drug called ONC206 in 90 people with advanced pheochromocytoma or paraganglioma, rare tumors of the adrenal glands. Participants must have tumors that cannot be removed by surgery and have not responded to or cannot have standard treatments. The study will measure how many patients' tumors shrink or disappear, and how long that effect lasts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ONC206 (a drug taken by mouth)
What this could lead to: If successful, this could provide a new treatment option for people with rare adrenal tumors that have stopped responding to standard therapies.
What could go wrong: This is a mid-stage trial with only 90 participants, so results may not apply to everyone. The drug may not shrink tumors or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adrenal gland pheochromocytoma paraganglioma pheochromocytoma pheochromocytoma-paraganglioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED PHEOCHROMOCYTOMA AND PARAGANGLIOMA PCPG

Contacts and locations

Locations

Columbia University Medical Center
NOT_YET_RECRUITING

New York, New York, 10032, United States
Mayo-Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
PENN
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Stanford
RECRUITING

Palo Alto, California, 94604, United States
U of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
U of Michigan
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
UCLA
RECRUITING

Los Angeles, California, 90095, United States
UTAH
RECRUITING

Salt Lake City, Utah, 84112, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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