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Scientists probe rare syndrome behind rapid childhood obesity

NCT ID NCT02602769

Recruiting now Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at children with ROHHAD syndrome, a rare condition that causes rapid weight gain and breathing problems. Researchers will take blood samples to create special cells in the lab and study their genetic activity. The goal is to understand what goes wrong in the body to cause such fast obesity. This is an observational study, not a treatment trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this research could reveal the biological causes of rapid obesity in ROHHAD syndrome, pointing toward future treatments.
What could go wrong
This is a very small, early-stage observational study with only 12 participants. It is not testing any treatment, so it may not lead directly to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypothalamic disorder morbid obesity Pediatric Obesity primary dysautonomia rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILDHOOD OBESITY MORBID OBESITY

Contacts and locations

Locations

  • Boston Children's Hospital

    COMPLETED

    Boston, New York, 02115, United States

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

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