Can a higher dose of misoprostol help women with severe obesity avoid C-Section?

NCT ID NCT06199154

Recruiting now Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether a 50 microgram dose of misoprostol works better than a 25 microgram dose for starting labor in pregnant women with a BMI over 40. The goal is to see if the higher dose can lead to more vaginal deliveries and fewer cesarean sections. Participants will receive one of the two doses placed in the vagina every four hours until labor progresses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: misoprostol (a medication used to induce labor)
What this could lead to: If a higher dose proves more effective, it could help more women with severe obesity achieve a vaginal delivery, reducing the need for cesarean sections and related surgical risks.
What could go wrong: This is an early-phase trial with a relatively small number of participants. The higher dose may not improve outcomes and could carry additional risks, such as excessive uterine contractions.

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Conditions

The condition(s) this trial relates to.

morbid obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MORBID OBESITY PREGNANCY

Contacts and locations

Locations

University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21201, United States

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