Could a simple ketone drink reduce the need for surgery in FAP patients?
NCT ID NCT06578637
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a daily ketone supplement (BHB) is safe and tolerable for people with Familial Adenomatous Polyposis (FAP), a genetic condition that causes many colon polyps and often leads to surgery. Twenty participants will take the supplement for two weeks to see if it raises BHB levels in the blood and if it can eventually slow polyp growth. The goal is to reduce the need for frequent scopes and surgeries.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- R-1,3-Butanediol (a ketone supplement that raises blood BHB levels)
- What this could lead to
- If it works, this could point toward a daily supplement that helps control polyp growth in FAP, reducing the need for frequent colonoscopies and surgeries.
- What could go wrong
- This is a very early, small trial (20 people) testing safety and blood levels, not yet whether it actually prevents polyps. The supplement may cause side effects or not work as hoped.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Abramson Cancer Center of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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