Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This pilot study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard surgery and antibiotics is feasible for treating infected leg fractures. Fifty adults with confirmed or suspected infection will be randomly assigned to re…

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila, a type of beneficial gut bacteria, can help adults recover after being treated for sepsis in the ICU. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will che…

This study will test a new way to manage heart disease risk using a digital, nurse-led remote monitoring program. About 750 adults with heart conditions will use home devices and answer questionnaires. The goal is to see if this approach helps more patients reach their cholestero…

This study compares 3D-printed hand orthoses (braces) to traditional custom-made ones in 100 adults with chronic hand conditions from nerve, muscle, or bone issues. The goal is to see if the 3D-printed versions work just as well for daily activities, are more satisfying, and cost…

This study tests whether a newer 'splintless' jaw surgery is more accurate and safer than the standard method for treating obstructive sleep apnea. About 66 adults with moderate to severe sleep apnea who cannot use CPAP will be randomly assigned to one of the two surgeries. Resea…

This study tests whether a mobile app that tracks periods and teaches about menstrual health can improve quality of life for teens with painful or heavy periods. About 874 adolescents who have started their periods and speak Dutch, English, Turkish, or Moroccan-Arabic will use th…

This study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…

This observational study will follow 500 children with hemophilia A who use non-factor therapy to prevent bleeding. Researchers want to understand why some children develop antibodies against factor VIII while others do not. By studying blood and stool samples over time, they hop…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study tests how the antifungal drug fluconazole changes the gut microbiome and immune system in 50 healthy men aged 18-35. Participants take one pill daily for 14 days or receive no treatment. Researchers will compare stool and blood samples over 6 months to see if and how l…

This observational study will collect data from 15,000 heart surgery patients across many hospitals worldwide. Researchers will look at how anesthesia, heart-lung machines, and surgical techniques are used, and track patient outcomes like recovery time and complications. The goal…

This study tests a new way for people to share their health data from wearables like smartwatches to help improve heart disease prevention. Researchers want to see if this approach can include groups often left out of research, such as women and people with lower incomes. About 4…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …

This study looks for proteins in the blood that could signal transfusion-related acute lung injury (TRALI), a rare but dangerous complication in ICU patients. Researchers will compare blood samples from 210 people, including ICU patients with and without lung injury, and healthy …