Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study is testing a procedure called duodenal mucosal resurfacing (DMR) to see if it can safely improve blood sugar control in people with type 2 diabetes who are not on insulin. About 18 adults will be randomly assigned to receive DMR or a sham (fake) procedure. The study wi…

This phase 2 trial tests different chemotherapy combinations for people with advanced stomach or esophageal cancer that has spread or cannot be removed. The study compares a new liposomal form of irinotecan plus other drugs against standard treatments to see which works best at s…

This study tests whether adding intravenous immunoglobulin (IVIg) to standard steroid treatment early in myositis helps patients improve faster. Myositis is a group of rare diseases causing muscle inflammation and weakness. The trial includes 44 adults diagnosed within the past y…

This study tests whether adding narrowband UVB phototherapy (a type of light treatment) to optimized topical therapy (creams, ointments, and skin care advice) helps adults with moderate atopic eczema more than topical therapy alone. About 316 adults whose eczema is not well contr…

This study tests whether icosapent ethyl, a purified fish-oil medication, can slow the buildup of calcium in the aortic valve. About 110 adults with mild-to-moderate aortic valve stenosis will take the drug or a placebo. The main goal is to see if the drug reduces the increase in…

This study tests a device called Endosign, which is a sponge on a string that patients swallow to collect cells from the esophagus. The goal is to see if this simple, non-sedation method can provide good enough samples to replace regular endoscopies for monitoring Barrett's esoph…

This study tests a therapy called imagery rescripting in 8 people with early psychosis. Participants imagine a different, more positive outcome to their traumatic memories. The goal is to see if this improves core beliefs, wellbeing, and self-esteem. It is a very small, early-pha…

This study looks at whether the spleen can be safely left in place during surgery for left-sided pancreatic cancer. Currently, the spleen is removed as a standard part of the operation to ensure any cancer in the surrounding fat is also taken out. The study will check how often c…

This study looks at whether a new imaging technique (nCLE) can confirm that a biopsy needle is correctly placed in a lung nodule. About 25 adults with suspicious lung nodules will have the extra imaging during their standard biopsy procedure. The goal is to see if this method mat…

This study looks at how combining blood tests (proteomics and genomics) with CT scans can help predict the worsening of coronary artery disease. Researchers will follow 310 adults aged 50-75 who have early signs of plaque in their heart arteries but no symptoms. The goal is to be…

This study brings together 40 international experts, including doctors and patients, to agree on a clear definition and severity ranking of lung complications that can occur after surgery. Through multiple rounds of surveys and interviews, the team hopes to create a standard way …