New chemo cocktail aims to fight esophageal cancer with fewer side effects

NCT ID NCT03764553

Ongoing Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests different chemotherapy combinations for people with advanced stomach or esophageal cancer that has spread or cannot be removed. The study compares a new liposomal form of irinotecan plus other drugs against standard treatments to see which works best at slowing cancer growth and causes less nerve damage. About 320 participants will be randomly assigned to one of three treatment groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Liposomal irinotecan, carboplatin, oxaliplatin, capecitabine, 5-fluorouracil, leucovorin
What this could lead to: If successful, this could identify a more effective and less nerve-damaging chemotherapy combination for advanced stomach or esophageal cancer.
What could go wrong: This is a mid-stage (phase 2) trial with 320 participants, so results are not definitive. The experimental combo may not improve survival or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms gastroesophageal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL CANCER

Contacts and locations

Show contact details

Locations

Academic Medical Center, Medical Oncology

Amsterdam, 1100 DD, Netherlands
Admiraal de Ruijter Ziekenhuis

Goes, 4460 AA, Netherlands
Amphia Ziekenhuis

Breda, 4818 CK, Netherlands
Bravis ziekenhuis locatie Roosendaal

Roosendaal, 4708 AE, Netherlands
Canisius Wilherlmina ziekenhuis

Nijmegen, Netherlands
Catherina Ziekenhuis

Eindhoven, Netherlands
Dijklander ziekenhuis

Hoorn, Netherlands
Elkerliek ziekenhuis

Helmond, Netherlands
Flevoziekenhuis

Almere Stad, Netherlands
Haaglanden Medisch Centrum

The Hague, Netherlands
Ikazia ziekenhuis

Rotterdam, Netherlands
Isala Klinieken

Zwolle, Netherlands
Jeroen Bosch Ziekenhuis

's-Hertogenbosch, 5223 GZ, Netherlands
Laurentius Ziekenhuis

Roermond, Netherlands
Leids Universitair Medisch Centrum

Leiden, Netherlands
Maasstadziekenhuis

Rotterdam, Netherlands
Meander MC

Amersfoort, Netherlands
Medisch Centrum Leeuwarden

Leeuwarden, Netherlands
Nij Smellinghe

Drachten, Netherlands
Radboud Universitair Medisch Centrum

Nijmegen, Netherlands
Reinier de Graaf Gasthuis

Delft, 2625 AD, Netherlands
Rijnstate Ziekenhuis

Arnhem, 6815 AD, Netherlands
Rivierenland Ziekenhuis

Rotterdam, Netherlands
Sint Antonius Ziekenhuis

Nieuwegein, Netherlands
Sint Jansdal

Harderwijk, Netherlands
Spaarne Gasthuis

Hoofddorp, Netherlands
Tergooi ziekenhuizen

Hilversum, Netherlands
Treant Zorggroep

Emmen, Netherlands
Treant zorggroep

Hoogeveen, 7909 AA, Netherlands
UMCU

Utrecht, 3508 GA, Netherlands
VieCurie

Roermond, 6043 CV, Netherlands
Ziekenhuis Gelderse Vallei

Ede, Netherlands
Ziekenhuisgroep Twente

Almelo, Netherlands
Zuyderland Medisch Centrum

Geleen, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.