Swallow a sponge to check for esophageal cancer?

NCT ID NCT07490340

Ongoing Diagnosis Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a device called Endosign, which is a sponge on a string that patients swallow to collect cells from the esophagus. The goal is to see if this simple, non-sedation method can provide good enough samples to replace regular endoscopies for monitoring Barrett's esophagus, a condition that can lead to esophageal cancer. The trial involves 60 adults with Barrett's esophagus, both with and without early cancer changes. If it works, it could make surveillance much easier and cheaper.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Endosign (sponge-on-a-string sampling device)
What this could lead to: If successful, this could offer a less invasive, cheaper way to monitor Barrett's esophagus, potentially catching esophageal cancer earlier.
What could go wrong: This is a small pilot study (60 people) testing only sample quality, not long-term outcomes. The device may not reliably replace endoscopy, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus Barrett esophagus disease esophageal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT ESOPHAGUS DIAGNOSIS ESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

Amsterdam University Medical Centre, loc. VUmc

Amsterdam, North Holland, 1081HV, Netherlands

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