Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This phase 2 trial tests whether vericiguat, a drug already used for heart failure, can improve blood vessel function in people with vasospastic angina—a type of chest pain caused by spasms in the heart's small arteries, not by blockages. About 57 adults with frequent angina symp…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study looked at 410 patients with a bile duct infection (cholangitis) who had a procedure to drain the bile duct. It compared giving antibiotics for just 1 day versus the usual 4 to 7 days. The goal was to see if the shorter course is just as good at curing the infection, wh…

This study tested a personalized approach using custom-made shoes and inserts to prevent foot ulcers from returning in people with diabetes. 126 adults with a history of foot ulcers were followed for 12 months. The goal was to see if this tailored approach could reduce ulcer recu…

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took either the drug combo or a placebo in cycles ove…

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic condition causing inflammation in the colon. 85 participants received either donor or their own stool via tubes and enemas. The goal was to see if donor transplant…

This study tested whether a personalized breathing machine setting during open abdominal surgery could prevent lung complications like pneumonia or respiratory failure. Over 1,400 patients at risk for lung problems were randomly assigned to either the personalized strategy or sta…

This study tested whether giving sickle cell patients two drugs (azathioprine and hydroxyurea) for three months before a stem cell transplant could help the transplant work better. Twenty adults with a matched sibling donor took part. The goal was to see if this approach could re…

This study combined data from nearly 4,000 stroke patients to see how often a heart CT scan finds blood clots that standard ultrasound might miss. Researchers looked at how well this quick scan, done during the initial stroke workup, detects clot sources in the heart. The goal is…

This pilot study tested a plastic stent with a retrieval string to drain bile in 40 people with resectable bile duct cancer. The goal was to see if the stent could safely reduce bile buildup before surgery. Researchers measured serious complications and how well the stent worked.

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, …

Sickle cell disease can affect brain development even in very young children. This study uses eye-tracking—a simple, non-invasive method—to measure attention and processing speed in infants aged 6 to 24 months. The goal is to identify those at highest risk for cognitive challenge…

This study looks at whether people who have been bitten many times by ticks can develop a natural resistance. Researchers placed uninfected ticks on 24 volunteers — some with a history of tick bites, some without — and measured how well the ticks fed. The goal is to understand if…

This study looked at whether it's safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD). The test involves purposely triggering a dangerous heart rhythm to make sure the device can stop it. About 965 people took part. T…

This study looked at how long it takes for a key stress hormone (cortisol) and its carrier protein to return to normal after healthy women stop taking combined oral contraceptive pills. Twenty-four women were followed for several weeks after stopping the pill. The goal was to und…

This study tested whether humans can develop immunity to tick bites by repeatedly exposing 11 volunteers to uninfected ticks. Researchers measured tick feeding success and signs of immune response like itching and redness. The goal is to see if tick immunity exists in people, whi…

This study tested whether an automated device called FlowSure can measure urine output more accurately than the usual manual method in hospital patients with a urinary catheter. 75 adults took part, and their urine was monitored over 8- and 24-hour periods. The goal was to see if…

This study brings together 35 healthcare professionals from around the world to agree on the best methods for clearing mucus from the airways of intubated, critically ill patients. Using a Delphi process, experts will vote on statements about humidification, inhaled therapies, su…

This study tested a technique called cold snare to collect larger pieces of tissue from the duodenum during a routine endoscopy. Researchers wanted to see if these samples were good enough for detailed analysis, including single cell RNA sequencing. The study involved 13 people a…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This completed study looked at whether the brain's central clock (the suprachiasmatic nucleus) works differently in people with insulin resistance or type 2 diabetes. Researchers used advanced MRI scans to measure brain activity over 24 hours in 28 obese adults with varying insul…

This study tested a new way of helping patients breathe during a procedure that destroys liver tumors with heat or electricity. The new method, called flow-controlled ventilation, keeps the diaphragm more still than standard methods, which could help doctors place needles more ac…

This study followed over 1,100 high-risk COVID-19 patients in the Netherlands who received new antiviral drugs or monoclonal antibodies. Researchers collected blood samples and nasal swabs over 90 days to see how the virus and the body's immune response changed during treatment. …

This study observed over 2,500 critically ill patients on breathing machines in intensive care units worldwide. Researchers tracked how doctors used fluids and blood pressure medicines, and looked for links to patient outcomes like length of stay and survival. The goal was to und…