Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tested whether giving two drugs (azathioprine and hydroxyurea) for three months before a stem cell transplant could help the transplant work better in adults with sickle cell disease. The goal was to help patients' bodies accept the donor cells more completely, potenti…

This large international study tested whether adjusting breathing pressure during open abdominal surgery could prevent lung complications afterward. Researchers compared standard anesthesia breathing settings to a personalized approach that kept pressure changes minimal. The goal…

This study compared two different ways to help patients breathe during a procedure to destroy liver tumors. Researchers tested whether a newer continuous-flow breathing method allows doctors to work more accurately than traditional breathing support. The trial involved 41 patient…

This study tested whether a combination of two drugs, dasatinib and quercetin, could reduce liver scarring (fibrosis) in people with fatty liver disease. Thirty adults with confirmed liver scarring participated in this early-stage trial. The goal was to see if clearing certain ag…

This study tested whether an automated device called FlowSure could accurately measure urine output in hospitalized patients with catheters. Researchers compared the device's readings to the standard manual method used by nurses over 8-hour and 24-hour periods. The goal was to se…

This study analyzed existing data from 3,940 stroke patients to see how well a special heart scan (cardiac CT) works for finding blood clots in the heart that may have caused the stroke. Researchers compared this scan to the standard heart ultrasound test and tracked patient outc…

This study tested whether a personalized package of custom shoe inserts and foot care could prevent painful foot ulcers from returning in people with diabetes. It involved 126 adults with diabetes who had previously healed a foot ulcer. Researchers compared the new personalized a…

This study aimed to understand if the brain's master clock, which controls daily rhythms, is disrupted in people with insulin resistance and type 2 diabetes. Researchers used a powerful brain scanner to measure the clock's activity in 28 obese adults with varying levels of insuli…

This study aimed to find out if people can develop immunity to tick bites, which could help create a future vaccine against tick-borne diseases. Eleven healthy volunteers who had never had a known tick bite were exposed to lab-raised, disease-free ticks multiple times over severa…

This study aimed to understand how a common antibiotic, ceftriaxone, moves through and is cleared from the bodies of patients with severe, decompensated liver cirrhosis. Researchers observed 20 hospitalized patients who were already receiving this antibiotic and having a procedur…

This study observed over 1,100 adults in the Netherlands who received new COVID-19 antibody or antiviral treatments. The goal was to see how the virus and the patient's body responded in real-world use, outside of controlled trials. Researchers collected blood and swab samples to…

This international study aimed to understand how doctors around the world give fluids and blood pressure medications to critically ill patients who are on breathing machines. Researchers observed over 2,500 patients to see if treatment practices differ between countries and how t…

This study aims to create international expert agreement on the best methods to clear mucus and maintain airways in critically ill patients who are on breathing machines. It does not test treatments on patients but instead gathers opinions from 35-40 experienced healthcare profes…

This study aimed to improve the way doctors collect and prepare small pieces of tissue from the first part of the small intestine (the duodenum). Researchers worked with 13 patients who were already scheduled for a specific upper digestive tract procedure. The goal was to get bet…