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Could one day of antibiotics be enough for bile duct infections?

NCT ID NCT05750966

Completed Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 410 patients with a bile duct infection (cholangitis) who had a procedure to drain the bile duct. It compared giving antibiotics for just 1 day versus the usual 4 to 7 days. The goal was to see if the shorter course is just as good at curing the infection, while possibly causing fewer side effects and shorter hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

antibiotics (e.g., ceftriaxone, gentamicin, ciprofloxacin)

What this could lead to

If successful, this could show that a very short course of antibiotics is enough after drainage, reducing side effects, hospital stays, and costs for patients with cholangitis.

What could go wrong

This is a completed trial, but results are not yet published. The shorter course might not work as well for all patients, especially those with more severe infections or underlying conditions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute cholangitis cholangitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLANGITIS

Contacts and locations

Locations

  • Albert Schweitzer Ziekenhuis

    Dordrecht, South Holland, 3318 AT, Netherlands

  • Alrijne Ziekenhuis

    Leiderdorp, South Holland, 2353 GA, Netherlands

  • Amstelland Ziekenhuis

    Amstelveen, North Holland, 1186 AM, Netherlands

  • Amsterdam UMC

    Amsterdam, North Holland, 1081 HZ, Netherlands

  • Canisius Wilhelmina Ziekenhuis

    Nijmegen, Gelderland, 6532 SZ, Netherlands

  • Catharina Ziekenhuis

    Eindhoven, North Brabant, 5623 EJ, Netherlands

  • Deventer Ziekenhuis

    Deventer, Overijssel, 7416 SE, Netherlands

  • Dijklander Ziekenhuis

    Hoorn, North Holland, 1624 AR, Netherlands

  • Elisabeth Tweesteden Ziekenhuis

    Tilburg, North Brabant, 5022 GC, Netherlands

  • Erasmus MC

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Flevoziekenhuis

    Almere Stad, Flevoland, 1315 RA, Netherlands

  • Groene Hart Ziekenhuis

    Gouda, South Holland, 2803 HH, Netherlands

  • Haaglanden Medisch Centrum

    The Hague, South Holland, 2512 VA, Netherlands

  • Isala

    Zwolle, Overijssel, 8025 AB, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands

  • Leids Universitair Medisch Centrum

    Leiden, South Holland, 2333 ZA, Netherlands

  • Maasstad Ziekenhuis

    Rotterdam, South Holland, 3079 DZ, Netherlands

  • Maastricht UMC+

    Maastricht, Limburg, 6229 HX, Netherlands

  • Martini Ziekenhuis

    Groningen, Provincie Groningen, 9728 NT, Netherlands

  • Meander MC

    Amersfoort, Utrecht, 3813 TZ, Netherlands

  • Medisch Centrum Leeuwarden

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Medisch Spectrum Twente

    Enschede, Overijssel, 7512 KZ, Netherlands

  • OLVG

    Amsterdam, North Holland, 1091 AC, Netherlands

  • Radboud umc

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Reinier de Graaf Gasthuis

    Delft, South Holland, 2625 AD, Netherlands

  • Rijnstate Ziekenhuis

    Arnhem, Gelderland, 6815 AD, Netherlands

  • Spaarne Gasthuis

    Hoofddorp, North Holland, 2134 TM, Netherlands

  • St. Antonius Ziekenhuis

    Nieuwegein, Utrecht, 3435 CM, Netherlands

  • Universitair Medisch Centrum Groningen

    Groningen, Provincie Groningen, 9713 GZ, Netherlands

  • Universitair Medisch Centrum Utrecht

    Utrecht, Utrecht, 3584 CX, Netherlands

  • Zaans Medisch Centrum

    Zaandam, North Holland, 1502 DV, Netherlands