Could one day of antibiotics be enough for bile duct infections?

NCT ID NCT05750966

Completed Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 410 patients with a bile duct infection (cholangitis) who had a procedure to drain the bile duct. It compared giving antibiotics for just 1 day versus the usual 4 to 7 days. The goal was to see if the shorter course is just as good at curing the infection, while possibly causing fewer side effects and shorter hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics (e.g., ceftriaxone, gentamicin, ciprofloxacin)
What this could lead to: If successful, this could show that a very short course of antibiotics is enough after drainage, reducing side effects, hospital stays, and costs for patients with cholangitis.
What could go wrong: This is a completed trial, but results are not yet published. The shorter course might not work as well for all patients, especially those with more severe infections or underlying conditions.

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Conditions

The condition(s) this trial relates to.

acute cholangitis cholangitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLANGITIS

Contacts and locations

Locations

Albert Schweitzer Ziekenhuis

Dordrecht, South Holland, 3318 AT, Netherlands
Alrijne Ziekenhuis

Leiderdorp, South Holland, 2353 GA, Netherlands
Amstelland Ziekenhuis

Amstelveen, North Holland, 1186 AM, Netherlands
Amsterdam UMC

Amsterdam, North Holland, 1081 HZ, Netherlands
Canisius Wilhelmina Ziekenhuis

Nijmegen, Gelderland, 6532 SZ, Netherlands
Catharina Ziekenhuis

Eindhoven, North Brabant, 5623 EJ, Netherlands
Deventer Ziekenhuis

Deventer, Overijssel, 7416 SE, Netherlands
Dijklander Ziekenhuis

Hoorn, North Holland, 1624 AR, Netherlands
Elisabeth Tweesteden Ziekenhuis

Tilburg, North Brabant, 5022 GC, Netherlands
Erasmus MC

Rotterdam, South Holland, 3015 GD, Netherlands
Flevoziekenhuis

Almere Stad, Flevoland, 1315 RA, Netherlands
Groene Hart Ziekenhuis

Gouda, South Holland, 2803 HH, Netherlands
Haaglanden Medisch Centrum

The Hague, South Holland, 2512 VA, Netherlands
Isala

Zwolle, Overijssel, 8025 AB, Netherlands
Jeroen Bosch Ziekenhuis

's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
Leids Universitair Medisch Centrum

Leiden, South Holland, 2333 ZA, Netherlands
Maasstad Ziekenhuis

Rotterdam, South Holland, 3079 DZ, Netherlands
Maastricht UMC+

Maastricht, Limburg, 6229 HX, Netherlands
Martini Ziekenhuis

Groningen, Provincie Groningen, 9728 NT, Netherlands
Meander MC

Amersfoort, Utrecht, 3813 TZ, Netherlands
Medisch Centrum Leeuwarden

Leeuwarden, Provincie Friesland, 8934 AD, Netherlands
Medisch Spectrum Twente

Enschede, Overijssel, 7512 KZ, Netherlands
OLVG

Amsterdam, North Holland, 1091 AC, Netherlands
Radboud umc

Nijmegen, Gelderland, 6525 GA, Netherlands
Reinier de Graaf Gasthuis

Delft, South Holland, 2625 AD, Netherlands
Rijnstate Ziekenhuis

Arnhem, Gelderland, 6815 AD, Netherlands
Spaarne Gasthuis

Hoofddorp, North Holland, 2134 TM, Netherlands
St. Antonius Ziekenhuis

Nieuwegein, Utrecht, 3435 CM, Netherlands
Universitair Medisch Centrum Groningen

Groningen, Provincie Groningen, 9713 GZ, Netherlands
Universitair Medisch Centrum Utrecht

Utrecht, Utrecht, 3584 CX, Netherlands
Zaans Medisch Centrum

Zaandam, North Holland, 1502 DV, Netherlands

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