Could one day of antibiotics be enough for bile duct infections?

NCT ID NCT05750966

First seen Feb 05, 2026 · Last updated May 09, 2026 · Updated 12 times

Summary

This study looks at whether giving antibiotics for just 1 day after a bile duct infection (cholangitis) has been drained is as effective as the usual 4 to 7 days. About 440 adults with this infection will be randomly assigned to either the short or standard course. The goal is to see if the shorter treatment can cure the infection just as well, while possibly causing fewer side effects and shortening hospital stays.

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Contacts and locations

Locations

  • Albert Schweitzer Ziekenhuis

    Dordrecht, South Holland, 3318 AT, Netherlands

  • Alrijne Ziekenhuis

    Leiderdorp, South Holland, 2353 GA, Netherlands

  • Amstelland Ziekenhuis

    Amstelveen, North Holland, 1186 AM, Netherlands

  • Amsterdam UMC

    Amsterdam, North Holland, 1081 HZ, Netherlands

  • Canisius Wilhelmina Ziekenhuis

    Nijmegen, Gelderland, 6532 SZ, Netherlands

  • Catharina Ziekenhuis

    Eindhoven, North Brabant, 5623 EJ, Netherlands

  • Deventer Ziekenhuis

    Deventer, Overijssel, 7416 SE, Netherlands

  • Dijklander Ziekenhuis

    Hoorn, North Holland, 1624 AR, Netherlands

  • Elisabeth Tweesteden Ziekenhuis

    Tilburg, North Brabant, 5022 GC, Netherlands

  • Erasmus MC

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Flevoziekenhuis

    Almere Stad, Flevoland, 1315 RA, Netherlands

  • Groene Hart Ziekenhuis

    Gouda, South Holland, 2803 HH, Netherlands

  • Haaglanden Medisch Centrum

    The Hague, South Holland, 2512 VA, Netherlands

  • Isala

    Zwolle, Overijssel, 8025 AB, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands

  • Leids Universitair Medisch Centrum

    Leiden, South Holland, 2333 ZA, Netherlands

  • Maasstad Ziekenhuis

    Rotterdam, South Holland, 3079 DZ, Netherlands

  • Maastricht UMC+

    Maastricht, Limburg, 6229 HX, Netherlands

  • Martini Ziekenhuis

    Groningen, 9728 NT, Netherlands

  • Meander MC

    Amersfoort, Utrecht, 3813 TZ, Netherlands

  • Medisch Centrum Leeuwarden

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Medisch Spectrum Twente

    Enschede, Overijssel, 7512 KZ, Netherlands

  • OLVG

    Amsterdam, North Holland, 1091 AC, Netherlands

  • Radboud umc

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Reinier de Graaf Gasthuis

    Delft, South Holland, 2625 AD, Netherlands

  • Rijnstate Ziekenhuis

    Arnhem, Gelderland, 6815 AD, Netherlands

  • Spaarne Gasthuis

    Hoofddorp, North Holland, 2134 TM, Netherlands

  • St. Antonius Ziekenhuis

    Nieuwegein, Utrecht, 3435 CM, Netherlands

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ, Netherlands

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX, Netherlands

  • Zaans Medisch Centrum

    Zaandam, North Holland, 1502 DV, Netherlands

Conditions

Explore the condition pages connected to this study.