Custom ventilation during surgery may cut lung risks
NCT ID NCT03884543
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a personalized breathing machine setting during open abdominal surgery could prevent lung complications like pneumonia or respiratory failure. Over 1,400 patients at risk for lung problems were randomly assigned to either the personalized strategy or standard care. The approach aimed to keep the lungs open with the least pressure needed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- individualized high PEEP ventilation strategy
- What this could lead to
- If successful, this could lead to a standard way to ventilate patients during open abdominal surgery to reduce lung complications.
- What could go wrong
- This trial is completed but results may not apply to all surgeries or patients. The strategy involves adjustments that may not work for everyone.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Amsterdam, Netherlands
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Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
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Amsterdam UMC location VUmc
Amsterdam, Netherlands
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Bermanntrost BG Klinikum Halle
Halle, Germany
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Bernhoven Hospital
Uden, Netherlands
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Erasmus Medisch Centrum
Rotterdam, Netherlands
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HAGA
The Hague, Netherlands
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Haaglanden Medisch Centrum
The Hague, Netherlands
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Heinrich-Heine University Hospital Dusseldorf
Düsseldorf, Germany
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Leiden UMC
Leiden, Netherlands
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Maastricht UMC
Maastricht, Netherlands
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Martini Hospital
Groningen, Netherlands
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Medical Center Leeuwarden
Leeuwarden, Netherlands
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Noordwest ziekenhuizengroep Alkmaar
Alkmaar, Netherlands
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Onze Lieve Vrouwen Gasthuis
Amsterdam, Netherlands
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Ospedale Policlinico San Martino
Genoa, Italy
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Radboud UMC
Nijmegen, Netherlands
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Rijnstate Hospital
Arnhem, Netherlands
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Spaarne Gasthuis Hospital
Haarlem, Netherlands
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UMC Groningen
Groningen, Netherlands
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University hospital Carl Gustav Carus
Dresden, Germany
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University hospital Napoli
Naples, Italy
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