Antifungal drug may reshape gut bacteria for months

NCT ID NCT07295314

Not yet recruiting Knowledge-focused Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests how the antifungal drug fluconazole changes the gut microbiome and immune system in 50 healthy men aged 18-35. Participants take one pill daily for 14 days or receive no treatment. Researchers will compare stool and blood samples over 6 months to see if and how long the microbiome changes last.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluconazole (antifungal drug)
What this could lead to: If successful, this could help doctors understand how antifungal medications impact gut health and immune function.
What could go wrong: This is a very early, small study in healthy young men, so results may not apply to patients or predict long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIFUNGAL THERAPY GUT MICROBIOME HEALTHY ADULT MALE

Contacts and locations

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Locations

Amsterdam UMC

Amsterdam, 1105 AZ, Netherlands

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