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Opening blocked heart arteries may beat drugs alone for reducing oxygen starvation

NCT ID NCT03756870

Recruiting now Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial tests whether opening a chronically blocked heart artery with a stent (PCI) reduces heart muscle starvation more than medication alone. It includes 48 patients with a total blockage who have significant ischemia on imaging. The study measures changes in ischemia, chest pain, and heart function over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
percutaneous coronary intervention (PCI) with a drug-eluting stent
What this could lead to
If PCI reduces ischemia more than medication alone, it could improve heart function and reduce chest pain in patients with blocked arteries.
What could go wrong
This is a small, early-phase trial with only 48 participants, so results may not apply broadly. PCI carries risks like bleeding, infection, or artery damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC TOTAL OCCLUSION OF CORONARY ARTERY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Amsterdam UMC, location AMC

    RECRUITING

    Amsterdam, 1105AZ, Netherlands

    Contact

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