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Which wrinkle treatment lasts longest? Head-to-Head trial of all five botox products

NCT ID NCT06448676

Symptom relief Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial compares the effectiveness and safety of all five commercially available botulinum toxin type A products for treating frown lines in women aged 18 and older. Participants receive injections into facial muscles and take weekly smartphone photos to track changes. The goal is to determine which product works best and how long the effects last.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
botulinum toxin type A
What this could lead to
If this trial succeeds, it could help doctors choose which botulinum toxin product works best and lasts longest for frown lines.
What could go wrong
This is a phase 4 trial comparing existing products, so no new treatment is being discovered. Results may not apply to men or other uses of botulinum toxin.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 325 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 18 years or over, with moderate to severe glabellar lines * Willing to provide written informed consent * American Society of Anesthesiologists (ASA) Physical Status Classification 1 or 2 * Negative pregnancy test Exclusion Criteria: * ASA Classification 3 or over * History of hypersensitivity or adverse reactions to botulinum toxin or any of its components * Infection at the injection site * Previous treatment with botulinum toxin (lifetime) * Pregnant or breastfeeding women * Neuromuscular disorders or conditions that could interfere with the study assessments

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glabellar frown lines Glabellar furrowing Wrinkle

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faceland

    RECRUITING

    Amsterdam, Netherlands

  • Faceland

    RECRUITING

    Eindhoven, Netherlands

  • Faceland

    RECRUITING

    Utrecht, Netherlands

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