Nuceiva safety checked in 756 patients for frown lines
NCT ID NCT05481931
First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 4 times
Summary
This completed study looked at the long-term safety of Nuceiva (a botulinum toxin injection) for treating moderate-to-severe frown lines between the eyebrows. It involved 756 adults under 65 who received the treatment in real-world clinics. The main goal was to track any side effects, especially eye problems or signs of the toxin spreading. The study did not test how well the treatment works, only its safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
prabotulinumtoxinA (a type of botulinum toxin, also known as Jeuveau or Nuceiva)
What this could lead to
If successful, this study could confirm that Nuceiva is safe for long-term use in treating frown lines.
What could go wrong
This is an observational safety study, not a test of effectiveness. It cannot prove the treatment works better than others, and rare side effects may still emerge.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
Contacts and locations
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Locations
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Cologne Dermatology
Cologne, Germany