Botox breakthrough? study tests if injection depth matters for wrinkle treatment

NCT ID NCT05766683

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study compares injecting Botox at two different depths (2mm vs 4mm) to treat frown lines between the eyebrows. Twenty adults will receive a one-time treatment, and researchers will measure how well each depth reduces wrinkles and any side effects. The goal is to find the optimal injection depth for best results with minimal risks.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
onabotulinumtoxinA (Botox)
What this could lead to
If it works, this could help doctors choose the best injection depth for treating frown lines with Botox, possibly improving results and reducing side effects.
What could go wrong
This is a very small, early-phase trial with only 20 people. The results may not apply to everyone, and the difference between depths might be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

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