Cure My Disease

Don't miss your cure!

 Log in / Sign up

Neck wrinkle fix: filler study compares two injection methods

NCT ID NCT04162496

Symptom relief Sponsor: Siperstein Dermatology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests Restylane Refyne, a hyaluronic acid filler, for treating horizontal neck lines in adults with mild to moderate wrinkles. Each participant receives the filler on one side of the neck with a cannula and on the other side with a needle, allowing a direct comparison. The goal is to see which method works better and causes fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Restylane Refyne (hyaluronic acid filler) injected via cannula or needle
What this could lead to
If successful, this could show that Restylane Refyne safely reduces neck wrinkles, offering a cosmetic option for aging skin.
What could go wrong
This is a small, early study with only 26 participants, so results may not apply widely. Risks include bruising, swelling, or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

26 people

The number who actually took part.

Started

Aug 2020

Finished

Nov 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * In good general health as evidenced by medical history * For females of reproductive potential: use of highly effective contraception * Score of 1--3 on a validated transverse neck line scale3 Exclusion Criteria: * Subjects with allergies to hyaluronic acid filler. * Subjects with auto--immune conditions * Subjects with diabetes * Subjects taking anti--coagulants, diuretics, anti-histamines, or anti--inflammatory medications in the 2 weeks prior to the study or who will need to take these medications at any time during the 60 day study. * Subjects with any scheduled laser, light, or surgical procedures during the study, including dental surgery. * Subjects who had neuromodulators in the past 6 months or fillers in the previous 2 years in the neck area * Subjects who at any time had surgery or permanent fillers in the neck area * Subjects with scars, tattoos, or many skin growths in the neck area * Subjects unwilling or unable to sit still while an injector places Restylane Refyne in the neck * Subjects unwilling or unable to keep their head still during the photos * Subjects who are pregnant or nursing * Female subjects unable to take or use some form of birth control * Subjects with any neck bruising or swelling * Subjects with current skin infections, tumors, herpes outbreak or dermatitis on the neck

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Aging are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Rhytides Wrinkle

Contacts and locations

Locations

  • Siperstein Dermatology

    Boynton Beach, Florida, 33472, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.