Nerve block may unlock secrets of dangerous heart rhythm

NCT ID NCT05377216

Recruiting now Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how a nerve block (stellate ganglion block) changes the heart's electrical activity in 20 people with ventricular tachycardia, a fast and potentially dangerous heart rhythm. Researchers will measure how the heart's refractory period changes and whether the nerve block affects the ability to trigger the arrhythmia. The goal is to better understand the role of the nervous system in this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stellate ganglion block (local anesthetic)
What this could lead to: If successful, this could point toward a new way to control dangerous heart rhythms by targeting nerve signals.
What could go wrong: This is a very small, early-phase study focused on measuring effects, not treating the condition. It may not lead to a practical therapy.

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Conditions

The condition(s) this trial relates to.

ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTRICULAR TACHYCARDIA

Contacts and locations

Locations

Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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