Hospices Civils De Lyon

This study tested two different chemotherapy combinations (R-ACVBP and R-CHOP) for younger adults with aggressive B-cell lymphoma. Treatment decisions were guided by PET scan results after the 2nd and 4th chemotherapy cycles, allowing doctors to adjust therapy based on how well t…

This study tested whether a special nurse-led support program could help elderly patients stay home and avoid returning to the hospital soon after discharge. The program provided a dedicated nurse who created a personalized discharge plan, educated patients and caregivers, and ch…

This study compared two surgical techniques used during total knee replacement: resurfacing the kneecap with an implant versus leaving the natural kneecap cartilage in place. It involved 250 adults with severe knee arthritis who needed a first-time knee replacement. Researchers f…

This study tested whether the drug bevacizumab could help adults with a rare inherited bleeding disorder called HHT who developed severe, life-threatening liver complications. The goal was to see if this drug treatment could improve heart function and liver health, offering an al…

This study investigated whether younger men with Klinefelter Syndrome have better chances of sperm retrieval than older men. Researchers compared sperm collection success rates between two age groups (15-22 years vs. 23-55 years) using testicular biopsies. The goal was to determi…

This study tested the safety and best dosing of a drug called cabozantinib for people with advanced liver cancer (hepatocellular carcinoma). It involved 110 patients whose cancer had progressed after trying the standard first-line treatment, sorafenib. The main goal was to see ho…

This study tested whether adding interferon to the standard drug nilotinib helps newly diagnosed chronic myeloid leukemia patients achieve a deeper reduction in leukemia cells. 200 patients were randomly assigned to receive either nilotinib alone or nilotinib plus interferon for …

This study compared two different surgical techniques for removing glioblastoma, a serious type of brain tumor. Researchers tested whether using a fluorescent dye that makes tumor cells glow under special light (fluorescence-guided surgery) was better than the standard computer n…

This study compared two different procedures for treating unruptured, bulging brain arteries (aneurysms). Researchers tested a newer method using a special flow-diverting stent against the traditional method of filling the bulge with tiny coils. The goal was to see which approach…

This study aimed to find out if surgically removing the primary rectal tumor before chemotherapy helps patients with incurable, spread cancer live longer than chemotherapy alone. It involved adults with rectal cancer that had spread to other organs where those secondary tumors co…

This study tested two different chemotherapy combinations to help keep acute myeloid leukemia (AML) from coming back after initial treatment. It involved 735 younger adults (ages 18-60) whose cancer had responded to first-round chemotherapy but who weren't candidates for stem cel…

This study tested whether a combination of protective treatments during heart valve surgery could reduce heart muscle damage compared to standard care. Researchers enrolled 210 patients undergoing aortic valve surgery and measured heart injury markers for 72 hours after surgery. …

This study compared two surgical methods for partial knee replacement in osteoarthritis patients. Researchers tested whether robotic assistance leads to better implant positioning and walking alignment than traditional manual surgery. The trial involved 66 adults with knee osteoa…

This study tested whether the immunotherapy drug avelumab could help women with a rare, pregnancy-related cancer called gestational trophoblastic neoplasia (GTN) that had stopped responding to standard chemotherapy. The trial involved 24 women whose cancer was resistant to prior …

This study tested whether applying an estrogen cream to the penis for two months before surgery could help reduce healing complications in boys with severe hypospadias. Researchers compared the estrogen cream against a placebo cream in 244 boys aged 9-36 months who needed surgica…

This study tested a two-part treatment for advanced cancer that has spread within the abdomen. First, surgeons removed all visible tumors. Then, they washed the abdominal cavity with a heated chemotherapy solution during the same operation. The goal was to see if this combined ap…

This study tested a synthetic surgical glue as an alternative to stitches or staples for securing mesh implants during laparoscopic surgery to repair pelvic organ prolapse. Researchers wanted to see if using this glue could reduce complications like vaginal erosion that sometimes…

This study compared two anesthesia methods for creating dialysis access in patients with advanced kidney failure. Researchers tested whether a regional nerve block (axillary block) leads to fewer early complications than standard local anesthesia. The goal was to determine which …

This study tested whether placing patients with severe acute respiratory distress syndrome (ARDS) in a face-down position for at least 16 hours daily could help them survive. Researchers compared 474 critically ill patients who were either placed face-down or kept on their backs.…

This study tested a new medical device called the Lina Librata system for women with heavy, irregular menstrual bleeding who did not want to have children. The procedure uses a balloon to destroy the uterine lining and was designed to be less painful, potentially allowing it to b…

This large study tested whether a single injection of an existing drug, cyclosporine, given right before a standard artery-opening procedure (stent), could improve long-term outcomes for people having a major heart attack. It aimed to see if protecting heart muscle during treatme…

This study tested whether transplanting two donor hands could restore function for people with double forearm amputations. Researchers followed 7 adult patients to see how their brains adapted to controlling the new hands. The goal was to offer an alternative to prosthetics by re…

This study tested whether creating a special hospital nutrition team could help staff better identify and care for children suffering from malnutrition. The team used alerts and guidelines to improve practices like weighing children and monitoring their nutrition. Researchers wan…

This study directly compared two types of gastric bypass surgery for people with severe obesity. Researchers wanted to see if a newer, simpler procedure called the Omega Loop Bypass was as effective and safe as the traditional Roux-en-Y surgery. They followed 256 patients for two…

This study compared two types of weight-loss surgery for people with severe obesity. It tested a newer procedure called SADI-S against the common standard, RYGB, to see which leads to more weight loss and fewer side effects over two years. Researchers followed 382 patients to mea…

This study looked at whether removing the fallopian tubes to prevent ovarian cancer affects a woman's remaining egg supply and future fertility. Researchers compared two different surgical sealing techniques in 96 women having this preventive procedure. They measured hormone leve…

This study checked if a standard high-dose vitamin D treatment was effective and safe for children and teens with chronic kidney disease, a transplant, or a kidney syndrome. Researchers gave 43 participants a single large dose of vitamin D and measured their vitamin D levels two …

This study aimed to find the most suitable first chemotherapy treatment for older, more vulnerable women with advanced ovarian cancer. It compared three different drug schedules to see which one was most successful at delivering a full course of treatment without causing severe s…

This study compared two surgical methods for placing dental implants in the upper back jaw where bone has shrunk. One method used a traditional bone graft (sinus lift), while the other used computer-guided surgery to place implants without needing the graft. Researchers wanted to…

This study tested whether combining two approved lung-scarring (IPF) drugs works better than switching to the other drug alone for patients whose disease keeps getting worse. It involved 279 adults whose lung function declined despite already taking one of the standard medication…

This study tested a medical device called ReVive SE that removes blood clots from blocked brain arteries during a stroke. Doctors used the device on one patient with a severe stroke caused by a large artery blockage. The goal was to see if this device helps restore blood flow eff…

This study tested if using a special containment bag during a common uterine fibroid surgery makes the procedure safer. Researchers compared two groups of 48 patients: one group had the fibroid tissue removed inside a protective bag, while the other had the standard procedure wit…

This study tested a medical device called Cavaterm™ to treat heavy, prolonged menstrual bleeding when medication doesn't work. It involved 20 women who had already undergone the procedure. The goal was to see how well the treatment controlled bleeding two months after the quick, …

This study compared two approaches for treating patients with multiple blocked heart arteries. Doctors either used standard imaging alone or combined it with a special pressure test (FFR) to decide which blockages truly needed treatment with stents or bypass surgery. The goal was…

This study looked at over 1100 adults with severe obesity who were prescribed the weight-loss medication Wegovy. Its main goal was to see how much weight people lost after one year and to figure out which types of patients responded best. Researchers used detailed health data and…

This study tested whether a simple procedure called remote ischemic conditioning could reduce organ failure in people with septic shock. Doctors used a blood pressure cuff on patients' arms to create brief, controlled periods of reduced blood flow, hoping this would trigger the b…

This study tested whether the drug olaparib could help control recurrent high-grade brain tumors that have a specific genetic change called an IDH mutation. The trial involved 35 adults in France whose brain cancer had returned after standard treatments like radiation and chemoth…

This study compared two methods for managing bleeding during liver transplant surgery. It tested a newer, faster blood test (ROTEM®) against standard lab tests to see which better guided treatment. The goal was to reduce the amount of blood products patients needed during the ope…

This study tested whether a new digital system could improve pregnancy care. The system helped coordinate appointments and information between pregnant women, their doctors, midwives, and hospitals based on each woman's specific risks. Researchers wanted to see if this approach l…

This study tested whether placing infants face-down (prone position) while they receive oxygen through a nasal tube helps them breathe better during severe bronchiolitis. Researchers compared this to the traditional face-up position to see if it reduced the need for more intensiv…

This study tested whether a support program could help mothers of premature babies breastfeed for longer. The program connected new mothers with trained volunteer mothers who had successfully breastfed their own premature babies. Researchers followed over 1,700 mother-baby pairs …

This study tested a strategy to personalize anti-rejection drugs for kidney transplant patients. Researchers used a routine biopsy taken 3 months after transplant to guide treatment. For patients with early signs of inflammation, they tested giving stronger treatment. For patient…

This study tested whether regular check-in calls and visits from nurses could help teenagers with type 1 diabetes better accept their condition and improve their blood sugar control. 77 teens with higher-than-target blood sugar levels were randomly assigned to receive either thei…

This study tested if it was safe to give an immunotherapy drug called nivolumab directly into the abdomen (intraperitoneal) after major surgery and heated chemotherapy (HIPEC) for advanced ovarian cancer. The main goal was to find the safest dose and see how well patients tolerat…

This study tested whether a personalized, home-based walking program could make dangerous plaque in the neck arteries more stable and less likely to cause a stroke. It involved 56 adults with significant carotid artery narrowing but no stroke symptoms. Participants used activity …

This study tested whether a technique called 'postconditioning' could reduce heart muscle damage during heart attack treatment. Researchers worked with 44 patients who had their first heart attack and needed emergency artery-opening procedures. They used special heart imaging to …

This study compared two surgical approaches for early-stage cervical cancer. One group received the standard full removal of pelvic lymph nodes, while the other received a more targeted biopsy of only the key 'sentinel' nodes. Researchers aimed to see if the less invasive approac…

This study tested whether methotrexate works as well as cyclosporine for adults with moderate-to-severe eczema (atopic dermatitis). Both drugs aim to control the disease, but cyclosporine carries risks like high blood pressure and kidney problems. Researchers enrolled 100 patient…

This study tested if a drug called pasireotide could help patients with a high-output enterostomy—a surgical opening in the bowel that leaks too much fluid. When standard medicines fail, this high fluid loss can cause dehydration and kidney problems, keeping patients in the hospi…

This study tested if a protective technique used during artery-opening procedures could still reduce heart damage if applied a few minutes later than usual. It involved 72 patients who had a major heart attack but still had some blood flow to the blocked artery. Researchers measu…

This study tested whether an additional surgical step (lateral retinaculum release) provides any benefit during standard surgery for recurrent kneecap dislocation. Researchers compared two surgical approaches in 140 adults aged 18-45 who needed knee stabilization surgery. The goa…

This study tested a precise, high-dose radiation technique called stereotactic radiotherapy for small kidney tumors (4 cm or less). It aimed to find the safest maximum dose for patients who are older, cannot have surgery, or have cancer that has spread. The treatment was given in…

This study tested whether switching kidney transplant patients who developed their first skin cancer from one type of anti-rejection drug (calcineurin inhibitors) to another (rapamycin) could prevent new skin cancers from forming over two years. It involved 77 patients who had re…

This study tested which treatment helps teens with Osgood Schlatter disease get back to sports faster. It compared putting the leg in a cast to simply resting from sports. The main goal was to see which group had more teens fully return to their sport within a year.

This study tested whether minoxidil, a blood pressure medication, could improve heart and blood vessel health in children with Williams-Beuren syndrome. The condition often causes serious heart problems due to a lack of the protein elastin. Researchers gave minoxidil or a placebo…

This study tested a method to keep fluid levels balanced in critically ill patients with failing kidneys who are on continuous dialysis. Researchers carefully matched the rate of fluid removal by the dialysis machine to the rate of fluids given to the patient, using advanced hear…

This study tested if a blood-filtering procedure called therapeutic plasma exchange (TPE) could help hospitalized COVID-19 patients with severe breathing problems. It compared standard intensive care alone to standard care plus TPE in 21 patients. The goal was to see if removing …

This study tested whether an automated computer system could manage a patient's IV fluids during major abdominal surgery as well as or better than an anesthesiologist. It involved 46 high-risk patients undergoing procedures like liver or pancreas surgery. The goal was to see if t…

This small pilot study tested whether giving intravenous immunoglobulins (IVIG) could help children with life-threatening toxic shock syndrome. The main goal was to see if it's possible to run a larger future trial by checking if enough children could be enrolled and if the treat…

This study tested a gentler way to use breathing machines for hospitalized COVID-19 patients with severe lung failure. Researchers compared the standard method to an 'ultraprotective' method that uses smaller, gentler breaths. The goal was to see if this gentler approach could he…

This study tested whether a drug called GM-CSF could reduce secondary infections in ICU patients recovering from severe sepsis or septic shock. Researchers enrolled 166 patients whose immune systems were weakened by their initial infection. Half received GM-CSF injections and hal…

This pilot study tested a special support program designed to help older adults with cancer prepare for and recover from major surgery. The program included physical exercise, nutritional guidance, and education before surgery, followed by support during the hospital stay and aft…

This study tested a new machine technique to prepare higher-risk donor livers before transplant surgery. The machine pumps a cold, oxygenated solution through the liver to potentially reduce damage and improve how well it works after surgery. Researchers compared this new method …

This study compared two different blood-filtering systems used to support patients with severe liver failure. The goal was to see if a newer, simpler, and less expensive system (SPAD) works as well as the standard, more complex system (MARS) at removing toxins from the blood. Eac…

This study tested if a phone call or video chat after leaving the hospital could help people who had a stroke better understand and follow their medication plan. Researchers worked with 54 stroke patients, giving them a medication review before discharge and then following up by …

This study tested the safety and effectiveness of a combination of three existing drugs—olaparib, cyclophosphamide, and metformin—for women with recurrent or advanced endometrial (uterine) cancer that had stopped responding to standard chemotherapy. The main goals were to find th…

This study tested a small, temporary tube (stent) placed in the urethra to help men with spinal cord injuries urinate more easily. The goal was to see if this removable device could be a good alternative to permanent, destructive surgery. Researchers measured how well it worked a…

This study aimed to find the best dose of a drug called ephedrine to quickly treat dangerously low blood pressure in babies under 6 months old during surgery. Low blood pressure under anesthesia is common in infants and may harm brain development. The trial tested different ephed…

This study compared two treatment approaches for people with a severe leak in their mitral heart valve and weakened heart muscle. Researchers tested whether adding a minimally invasive procedure (using the MitraClip device) to the best standard medical care was better than standa…

This study tested a two-step transplant approach for patients under 65 with aggressive myeloma. After an initial transplant, patients who had a partial response received a second, gentler transplant from a donor. The goal was to better control the disease and improve survival by …

This study tested whether a special support program helps women aged 70+ stick to their breast cancer hormone therapy. The program included weekly Tai Chi, nutritional advice, vitamin D checks, and regular medical follow-ups to manage joint pain and other side effects. Researcher…

This study tested whether surgery for pelvic organ prolapse (a condition where pelvic organs drop) could be safely performed as a same-day outpatient procedure instead of requiring a hospital stay. Researchers followed 38 patients to see if they could go home the same day and tra…

This study tested whether giving the drug somatostatin after liver cancer surgery could prevent a serious complication called ascites, which is fluid buildup in the abdomen. It involved 179 patients with liver cancer and underlying liver disease who had surgery to remove part of …

This study tested a specific method of breathing support to see if it helps critically ill adults who are struggling to come off a ventilator. It compared a combination of air pressure supports to a standard test to find which one helps patients breathe on their own successfully …

This study tested whether the drug tocilizumab could reduce bone pain and damage in people with fibrous dysplasia, a rare bone disorder. It focused on 19 patients who continued to have significant pain despite receiving standard bisphosphonate therapy. Researchers compared tocili…

This study compared two ways to treat high-grade dysplasia, a serious precancerous condition, in patients with Barrett's esophagus. It tested a less invasive balloon procedure that uses radiofrequency energy to destroy abnormal cells against the standard major surgery (esophagect…

This study tested a focused ultrasound treatment (HIFU) for men with intermediate-risk prostate cancer that is confined to one area. The goal was to see if precisely destroying only the cancerous part of the prostate could effectively control the disease while causing fewer side …

This study tested whether adding the drug bevacizumab to standard chemotherapy (Folfiri) could help patients with aggressive neuroendocrine cancer live longer after their initial treatment stopped working. The trial involved 153 adults whose cancer had progressed despite first-li…

This study tested a new light-detection tool to help surgeons see the edges of brain tumors more clearly during surgery. The goal was to see if this method could safely and effectively distinguish tumor tissue from healthy brain tissue in real time. Eleven adult patients with bra…

This study tested how well a simple, non-invasive stomach ultrasound can detect if a child has a risky amount of fluid in their stomach before receiving anesthesia. Researchers worked with 92 healthy children, having them drink specific amounts of liquid and then using ultrasound…

This study aimed to find a better way to diagnose a serious blood infection called sepsis in newborns. Researchers tested a combination of blood markers to see if they could rule out infection faster and more accurately than current methods. The goal was to help doctors avoid giv…

This study tested a new automated device called DiCART TM that measures how quickly blood returns to the skin after pressure is applied, a test known as capillary refill time. Doctors currently do this test by hand, which can lead to inconsistent results. The study involved 20 he…

This study compared two methods for detecting aggressive prostate cancer. Researchers tested whether using MRI scans to guide biopsy needles (targeted biopsies) finds dangerous cancers better than the standard method of taking many random samples (systematic biopsies). The trial …

This study tested a new method to quickly detect fungal infections in the abdominal fluid of ICU patients with peritonitis. It compared a new lab test to the standard, slower method to see if it could help doctors start life-saving antifungal treatment earlier. The goal was to im…

This study looked at whether a simple observation during a physical exam—one knee not bending as far as the other—could reliably indicate a specific type of dislocated meniscus in children. Researchers examined 98 children under 18 who had a painful, abnormally shaped meniscus (d…

This study tested two imaging methods—a special ultrasound called Histoscanning and a detailed MRI—to see how well they could find and locate prostate cancer that has come back after radiation treatment. It involved 30 men whose cancer was suspected to have returned. The main goa…

This study tested seven new blood markers to help doctors quickly and accurately tell if a fever in a young child is caused by a serious bacterial infection or just a virus. It involved nearly 1,000 children under 3 years old who came to the hospital with a fever. The goal was to…

This study tested whether measuring how much the knee moves during an MRI scan could help doctors better diagnose partial tears of the ACL, a common knee ligament. Researchers enrolled 151 people with knee injuries who were already scheduled for an MRI. They compared the new 'dyn…

This study tested whether a special combined PET/MRI brain scan was practical to use in children with a common type of brain tumor. The goal was to see if this scan could provide clearer pictures to help doctors identify the specific tumor type before surgery. Fifteen children ag…

This study tested whether a heart ultrasound (echocardiography) could help doctors better diagnose kidney problems in people with advanced liver disease (cirrhosis). Researchers examined 28 patients with sudden kidney injury to see if the ultrasound could predict who would benefi…

This study aimed to find the best way to screen for advanced liver scarring (fibrosis) in people at high risk, such as those with type 2 diabetes or obesity. Researchers tested combinations of simple blood tests and a special ultrasound scan in 1,000 patients to see which method …

This study tested a new method to predict when critically ill patients receiving kidney support therapy are at risk of a dangerous drop in blood pressure. Researchers quickly removed a small amount of fluid from 20 patients and measured how their hearts responded, comparing it to…

This study tested a new, step-by-step method for finding the cause of uveitis, a type of eye inflammation. Researchers compared this new, standardized approach to the usual method where doctors freely choose tests. The goal was to see if the new method was just as good at finding…

This study looked at whether using a lung ultrasound machine in the emergency room could help patients with severe shortness of breath. Researchers followed 385 patients to see if getting this quick, non-invasive scan led to better diagnoses, which might help them live longer and…

This study tested whether an ultrasound scan of the stomach works better when a patient is lying flat or tilted at a 45-degree angle. Researchers wanted to see if this scan could accurately detect when a stomach contains too much fluid, which can be dangerous during anesthesia. T…

This study aimed to create a simple questionnaire that predicts whether someone has low vitamin D levels, without needing a blood test. Researchers collected information from over 2,500 adults about their sun exposure, diet, and health factors, then compared it to their actual vi…

This study tested a new type of mouthguard called BRUXENSE to see if it could be a practical tool for diagnosing bruxism, or teeth grinding. Researchers wanted to know if people could comfortably wear the device for 10 nights to collect enough data for a diagnosis. The goal was t…

This study tested whether giving family doctors portable ultrasound machines helps them manage common conditions better. For six months, some doctors used the handheld scanners during patient visits for issues like pneumonia, kidney stones, or pregnancy concerns, while others did…

This study tested a new method to help anesthesiologists decide how much fluid to give children during surgery. Researchers checked if a very small, quick fluid dose (3 ml/kg) could accurately predict how a child's heart would respond to the standard, larger fluid dose (15 ml/kg)…

This study tested whether using a simple ultrasound scan to check if a child's stomach is empty before emergency surgery could help doctors choose a safer anesthesia method. Researchers scanned 146 children aged 0-18 before their operations to see if the scan results changed how …

This study tested a new, ultra-low-dose chest CT scan for people with Hereditary Hemorrhagic Telangiectasia (HHT). HHT patients need regular chest scans to find dangerous lung blood vessel malformations that can cause strokes. Researchers compared this new, lower-radiation scan t…

This study tested a new, non-invasive method to detect high pressure inside the skull (intracranial hypertension) in children with brain injuries. Researchers used a simple ultrasound scan to measure the width of the optic nerve behind the eye, which can swell when brain pressure…

This study tested a new type of combined PET/MRI scan to see if it could better find the tiny pituitary tumors that cause Cushing's disease. The goal was to improve the accuracy of diagnosis so that surgeons have a clearer target, potentially leading to more successful operations…

This study aimed to see if a newer, more detailed swallowing test (high-resolution manometry) is better at finding the cause of unexplained swallowing problems than the older standard test. It involved 247 adults in France who had trouble swallowing but no clear cause found on a …

This study tested whether a newer type of scanner (cone-beam CT) works as well as the standard CT scanner for finding cartilage damage in joints like the wrist, ankle, elbow, and knee. 69 adult patients who needed a joint scan received both types of scans. Researchers compared th…

This study aimed to improve the standard tuberculosis (TB) skin test. Researchers tested a new, easier-to-use needle and a non-invasive machine to read the results, hoping to make the test simpler and more consistent. The study involved 59 healthy volunteers to compare the new me…

This study tested a new imaging tool called Cellvizio® to see if it could spot very early signs of ovarian cancer in the fallopian tubes during surgery. It involved 40 women who were already having their fallopian tubes removed for various reasons. The main goal was to see if the…

This study tested a new type of detailed eye scan called microperimetry. The goal was to see if this scan could predict when a patient's age-related macular degeneration (AMD) would get worse, moving from an intermediate to a severe stage. It focused on 182 patients who already h…

This study tested if a cone-beam CT scanner, commonly used for dental imaging, could be as good as a standard CT scanner at finding and classifying broken bones in the hands and feet. 43 adult patients with suspected fractures had both scans. Researchers compared how well each sc…

This study tested a hospital program designed to prevent falls in elderly patients during their hospital stay. The program involved multiple healthcare professionals working together to identify fall risks and teach patients how to avoid falls. Researchers enrolled 1,852 patients…

This study tested whether eating specially fortified food products daily for 9 weeks could reduce low-grade inflammation linked to heart disease and obesity. Researchers compared these foods to standard products in 62 adults with abdominal obesity. They measured many blood marker…

This study tested whether a simple education program could help women over 50 get the right care after a wrist or arm fracture to prevent future, more serious breaks. It involved 436 women who had recently broken a bone from a minor fall. Half received information about osteoporo…

This study tested a special nursing care plan designed to prevent pressure sores (bed sores) in very sick patients with severe lung failure. The patients were in intensive care and had to lie face-down to help them breathe. Researchers compared whether the new nursing strategy re…

This study tested a new care program designed to prevent older adults from losing their ability to move around independently. It involved 39 participants over age 70 who were starting to have mobility issues. The program combined personalized exercise training with nutritional ad…

This study tested whether switching heart transplant patients from standard anti-rejection drugs to a medication called everolimus could help prevent new skin cancers. It involved 175 patients who had already developed skin cancer after their transplant. Researchers compared how …

This study tested whether giving a seizure-preventing drug right after a bleeding stroke could stop seizures and improve recovery. It involved 104 adults who had recently suffered this type of stroke. Patients were randomly assigned to receive either the real drug or a placebo to…

This study tested if a single dose of naloxone, a drug used to reverse opioid overdoses, could prevent life-threatening breathing pauses that sometimes occur right after a severe epileptic seizure. Researchers gave the injection or a placebo to 485 adults with hard-to-treat epile…

This study tested whether prazosin, a blood pressure medication, could prevent post-traumatic stress disorder (PTSD) in people who recently experienced trauma. Researchers enrolled 15 adults who visited emergency departments after accidents or assaults and showed early stress sym…

This study tested whether a special exercise and education program could prevent back pain from coming back in healthcare workers who had previous back pain. Researchers followed 351 hospital workers for two years to see if the program reduced repeat back pain episodes and sick l…

This study tested whether a brief ear acupuncture treatment could reduce anxiety in mothers before a planned cesarean section. Researchers compared real acupuncture needles to fake patches and no treatment in 91 participants. The goal was to find a drug-free way to ease common an…

This study tested whether showing patients real-time ultrasound images of their tongue movements during speech therapy helps them improve more than standard therapy alone. It involved 18 adults who had throat surgery for cancer and children with speech problems from brain injurie…

This study compared two ways to reduce anxiety in children before outpatient surgery. Researchers tested whether playing with an interactive electronic tablet was as effective as taking a sedative medication (midazolam). The trial involved 118 children aged 4 to 10 years, measuri…

This study tested whether clonidine, a medication commonly used for high blood pressure, could help reduce impulsive and compulsive behaviors in people with Parkinson's disease. Thirty-eight participants with Parkinson's and significant impulse control issues were randomly assign…

This small study tested whether placing infants with severe viral bronchiolitis in a face-down (prone) position makes breathing easier for them compared to lying on their back. Researchers measured breathing effort and lung pressure in 16 hospitalized infants under 6 months old w…

This study tested whether giving the common local anesthetic lidocaine through an IV during head and neck cancer surgery could help manage pain. The main goal was to see if it reduced patients' need for strong opioid painkillers like morphine in the first two days after surgery. …

This study tested a new physical therapy method for patients recovering from severe COVID-19. It compared standard cycling exercise to cycling combined with functional electrical stimulation (FES), which uses small electrical pulses to help muscles contract. The goal was to see i…

This study tested whether regular cycling during dialysis sessions could improve blood flow in the legs of patients with kidney failure. Researchers enrolled 27 adults on long-term dialysis who agreed to pedal for 30 minutes during their treatment. The main goal was to see if thr…

This study tested two different painkiller combinations delivered through a small tube placed near the spine to manage pain after minimally invasive lung surgery. Researchers compared a standard local anesthetic against that same anesthetic mixed with a strong opioid pain medicat…

This study tested different doses of melatonin to see which one best improves sleep quality in children with autism who have trouble sleeping. Researchers worked with 26 autistic children aged 3-12 to measure how melatonin affected their nighttime awakenings, sleep patterns, and …

This study tested whether giving patients clear education about pain and painkillers before outpatient orthopedic surgery would help them manage their pain better at home. Over 400 adults having procedures like knee or shoulder surgery were involved. Researchers compared the stan…

This study tested whether foot reflexology, a type of massage, could help reduce the severe nausea and vomiting caused by certain chemotherapy drugs in patients with lung or digestive system cancers. Researchers enrolled 80 patients to compare those who received reflexology with …

This study tested whether a 5-month mindfulness meditation program could improve mental well-being for hospital staff. It involved 108 healthcare professionals who either participated in the meditation sessions or were in a comparison group. Researchers measured changes in work-r…

This study tested whether involving a supportive care team early could improve quality of life for adults with acute leukemia that has returned for the first time. It compared 49 patients who received this early care to a group who did not. The main goal was to see if this approa…

This study tested a new virtual reality training program designed to help people with hearing loss locate where sounds are coming from. Researchers enrolled 79 adults, including people with normal hearing and those with deafness or cochlear implants. Participants used a VR system…

This study tested whether magnetic stimulation applied to the brain could reduce the severity of chronic tinnitus—persistent ringing in the ears. Researchers compared different levels of magnetic treatment against a sham (fake) procedure in 64 adults with severe, long-term tinnit…

This study tested two existing medications, gabapentin and memantine, to see if they could reduce involuntary eye movements (called pendular nystagmus) in people with multiple sclerosis. Researchers worked with 10 patients to measure how well the drugs improved eye stability, vis…

This study tested whether a gentle, non-invasive electrical brain stimulation could reduce chronic nerve pain. It involved 24 people, including both healthy volunteers and patients with long-term, treatment-resistant pain. Researchers compared the effects of real stimulation to a…

This small, completed pilot study explored whether a non-invasive electrical stimulation device, placed on the ear to target the vagus nerve, could improve symptoms and quality of life for women with Irritable Bowel Syndrome (IBS). The study followed 10 women for 6 months to see …

This study tested whether two existing medications, gabapentin and memantine, could reduce involuntary, shaking eye movements (called pendular nystagmus) in people with a specific brainstem condition. Seven adult patients with oculopalatal tremor participated. Researchers measure…

This study tested whether automatic movement exercises work better than traditional intentional exercises for improving arm function after a stroke. Researchers compared these two approaches in 26 stroke survivors with arm weakness. The goal was to see if automatic movements, whi…

This study tested a new rehabilitation method for people who have lost part of their vision after a stroke or brain injury. The training aimed to improve their ability to search and see things in their blind spot by using automatic eye movements, rather than requiring intense con…

This study looked at whether CFTR modulator drugs, which are known to help lung function in cystic fibrosis, also improve sinus symptoms and quality of life in children aged 6 to 11. Researchers followed 27 children for a year, using a special questionnaire to track changes in th…

This study checked if giving the pain medication lidocaine through an IV is safe for very obese patients having weight-loss surgery. Researchers measured the drug levels in patients' blood to see if a standard, weight-based dose was safe and didn't cause harmful side effects. The…

This study compared two types of anesthesia for older adults having urgent hip fracture surgery. Researchers wanted to see if a specific spinal anesthesia technique caused fewer dangerous drops in blood pressure during surgery compared to general anesthesia. They also tracked whe…

This study tested whether wearing a custom-made compression vest could help adults with hypermobile Ehlers-Danlos syndrome (hEDS). Forty-eight participants wore the garment for four weeks and then went without it for four weeks to compare the effects. Researchers measured changes…

This study tested whether using hearing aids could help people who have both Alzheimer's disease and age-related hearing loss. For one year, researchers compared two groups: one received real hearing aids immediately, while the other started with inactive 'placebo' devices. The g…

This study tested whether a new virtual reality training program could help adults who use two cochlear implants. The goal was to see if practice with visual or combined audio-visual feedback could improve their ability to tell where sounds are coming from in space. Twelve partic…

This study tested if injecting Botox into two specific leg muscles works better than treating just one muscle to reduce stiffness and improve walking in children with cerebral palsy. Researchers compared how well children could move and walk before treatment and then 2 and 6 mont…

This study looked at a surgery for pelvic organ prolapse that uses the patient's own tissue instead of an artificial mesh. It involved 66 women to see if this approach improved their symptoms, like pelvic pressure or bladder problems. The goal was to understand if this mesh-free …

This study looked at a minimally invasive treatment for women with urinary incontinence. It tested a gel injection called Bulkamid, given around the urethra, to help reduce urine leakage. The goal was to see how many patients reported an improvement in their symptoms after receiv…

This study tested whether a non-invasive brain stimulation technique called tDCS could help reduce persistent symptoms in people with schizophrenia who were already taking medication. 141 participants received either real or fake (sham) stimulation sessions over 5 days to see if …

This study tested whether injecting botulinum toxin (Botox) into the lower esophagus could safely reduce symptoms like chest pain and trouble swallowing in people with hypercontractile esophageal motility disorders. In this small, double-blind trial, 24 participants were randomly…

This study tested whether a safe, personalized exercise program could help children and teenagers with osteogenesis imperfecta (brittle bone disease). Thirty participants aged 6 to 18 followed a supervised, one-year training program designed to be safe for their condition. The ma…

This study compared two different pain control methods for patients having knee replacement surgery. Researchers tested whether a newer nerve block technique provides better pain relief with fewer side effects than the standard method. The goal was to help patients recover faster…

This study aimed to understand how the healthy brain performs 'checking' processes, like verifying information or decisions. Researchers used brain scans (fMRI and EEG) on 51 healthy volunteers while they performed thinking tasks. The goal was to map which brain areas are involve…

This study aimed to test how well a specific questionnaire (the ADHD-IV rating scale) can detect changes in attention and hyperactivity symptoms in children who have both epilepsy and ADHD. Researchers followed 173 children aged 6-15 to see if the scale's scores changed over 12-1…

This study aimed to understand how a newer, more responsive breathing machine (NAVA) compares to a standard machine for newborns recovering from surgery to repair a hole in their diaphragm. Researchers measured how hard eight babies worked to breathe and how well they synchronize…

This study aimed to create better computer models of human fingertips by taking detailed MRI scans. Researchers scanned the index fingers of eight healthy volunteers while applying different amounts of pressure. The data will help engineers design more realistic robotic hands and…

This study aimed to understand how consistently patients with cystinosis take their cysteamine medication and how that affects cystine levels in their bodies and potential brain complications. Researchers followed 65 patients over two years, using electronic monitors to track pil…

This study aims to understand how training eye movements affects visual perception and attention in the brain. It involves 24 adults with cerebellum disease or stroke-related brain injury, along with healthy volunteers. Researchers will measure changes in eye movement accuracy an…

This study aimed to test a new method for measuring airway closure during normal breathing in patients with severe Acute Respiratory Distress Syndrome (ARDS) who were on ventilators in the intensive care unit. Researchers enrolled 25 critically ill patients to assess how their lu…

This study investigated why hospitalized children aged 2-8 often eat less food during their stay, which can worsen malnutrition and slow recovery. Researchers measured how much children's natural pickiness and family background affected their hospital meal consumption. They colle…

This study created a large national database and tissue bank from over 2,100 patients with advanced digestive cancer that had spread to the abdominal lining. The purpose was to collect high-quality samples and detailed patient information to help researchers understand why treatm…

This study aimed to understand if a patient's position in bed changes a key measurement used to set ventilator support for people with severe lung failure (ARDS). Researchers measured pressure in the esophagus in 11 critically ill patients while they were lying flat and while the…

This study aimed to understand why diabetes develops in people with cystic fibrosis and why it sometimes reverses on its own. Researchers followed 230 cystic fibrosis patients in France to track their blood sugar patterns over time. They examined factors like genetics, lung healt…

This study aimed to find out if using an ultrasound machine to guide the placement of emergency catheters in the groin is safer than the standard method of using only touch and anatomical landmarks. It involved 136 severely injured adult patients in intensive care who needed thes…

This study aimed to understand the precise hand motions and forces used by healthcare workers when inserting an IV catheter. Researchers measured these actions in healthy volunteers using special sensors and cameras. The goal was to use this data to build better training simulato…

This study measured what patients know about transient ischemic attacks (TIAs), often called 'mini-strokes,' after visiting the emergency room. Researchers surveyed 100 patients in Lyon, France, to understand their awareness of TIA symptoms, risk factors, and when to seek help. T…

This study followed 255 women who developed diabetes during pregnancy (gestational diabetes) to understand who is most at risk for developing type 2 diabetes later. Researchers measured specific blood markers during pregnancy to see if they could predict which women would have ab…

This study collected information from 143 patients who had phalloplasty surgery to understand their surgical results, quality of life, and satisfaction. Researchers followed transgender and cisgender male patients for at least one year after their procedures to learn what works w…

This small pilot study aimed to better understand how the body digests and uses fiber from wheat bran. Six healthy women ate biscuits containing a special, traceable form of wheat bran. Researchers then collected breath, blood, urine, and stool samples over 24 hours to track how …

This study aimed to find out how many older adults in a hospital acute care unit have low vitamin C levels. Researchers measured vitamin C in the blood of 434 patients aged 75 and older. The goal was to understand how common this problem is and what factors might increase a perso…

This study aims to understand the long-term social and psychological effects on young adults who have recovered from NMDA receptor encephalitis, a rare autoimmune brain disease. Researchers followed 20 patients to assess how the disease affects their daily lives, work, education,…

This study tested a new type of combined PET/MRI scan to see if it could better identify dangerous, unstable plaques in the carotid arteries. Researchers compared scans from 12 people, half who had recently had a stroke and half who had not, to look for differences. The goal was …

This study aimed to better understand the genetic and immune system causes of lupus, especially in children and families. Researchers analyzed blood samples from 271 participants with lupus to look for specific gene changes and measure immune cell activity. The goal was to connec…

This study aimed to understand how common vitamin C deficiency is among elderly residents in long-term care facilities. Researchers enrolled 100 participants aged 65+ to measure their vitamin C blood levels and identify factors that increase deficiency risk. The goal was to gathe…

This study aims to understand why some patients with rare intestinal cholesterol disorders still develop vision problems despite taking high-dose vitamin supplements. Researchers will measure pigment density in the back of the eye (macula) in 10 patients with these conditions. Th…

This study aimed to better understand Parkinson's disease by comparing the brains of people with the condition to healthy volunteers. Researchers used PET scans to measure levels of a specific brain receptor (5-HT4) in 40 participants. The goal was to see if changes in this recep…

This study aimed to understand how advanced kidney disease affects body fat tissue. Researchers collected small fat samples from 23 men during routine surgeries—15 with kidney disease and 8 healthy volunteers. They examined the fat cells' size and function to learn why metabolism…

This study aimed to better understand how influenza affects hospital emergency departments. Researchers tested over 2,400 adult patients visiting the emergency room during flu season to see how many actually had the flu. The goal was to gather data to help hospitals prepare resou…

This study aimed to understand how our brains process different kinds of feedback, like social praise or monetary rewards, when we make decisions. Researchers worked with 76 healthy volunteers, using brain scans and a mild, safe ear stimulation technique to see which brain areas …

This study explored whether a heart scan performed during light exercise could spot early signs of heart strain in people with a rare genetic bleeding disorder (HHT) who also have liver complications. Researchers tested 47 adult patients to see if their lung blood pressure rose m…

This study tested whether taking a daily fiber supplement for three weeks could change the types and activity of gut bacteria in people at risk for heart disease and obesity. Researchers measured bacteria and other health markers in stool, blood, and breath to see if the fiber im…

This study looked at how chemotherapy affects taste and smell in people with digestive cancers. Researchers followed 69 patients to track changes in their food preferences and eating habits after starting treatment. The goal was to understand how these sensory changes impact nutr…

This study used brain scans to measure how a special tracer chemical attaches to stress-related receptors in healthy men's brains. Researchers tested the scanning method's reliability and how a blood pressure medication affects these receptors. The goal was to gather basic inform…

This study aimed to understand how often healthcare workers get the flu, both with and without symptoms. Researchers tracked 289 healthcare workers in hospitals to see how many caught the flu during the season. The goal was to measure the risk of silent transmission to patients a…

This study aimed to understand if the brain activity of women with obesity and eating disorders is similar to that seen in drug or alcohol addiction. Researchers measured brain waves in 108 women, comparing lean women, obese women without eating disorders, and obese women with ea…

This study aimed to understand why osteogenesis imperfecta (brittle bone disease) varies in severity from person to person. Researchers analyzed blood samples from 66 adults with different forms of the disease to look for tiny molecules called microRNAs that might be linked to ho…

This study aimed to understand why some patients develop delayed brain damage after a type of severe brain bleed called an aneurysmal subarachnoid hemorrhage. Researchers monitored 90 patients in intensive care, measuring specific markers in their blood platelets over time. The g…

This study aimed to better understand Hereditary Hemorrhagic Telangiectasia (HHT), a genetic disorder that causes abnormal blood vessel formation and bleeding. Researchers collected umbilical cord blood and tissue from 16 newborns who had a parent with HHT. They grew and analyzed…

This study aimed to understand how mouth sensations like texture, temperature, and spiciness affect food preferences in people with head and neck cancer. Researchers compared 72 participants—some with cancer and some healthy volunteers—by testing their mouth sensitivity and askin…

This study collected MRI and ultrasound images from two prostate cancer patients to create a database. The goal is to help researchers develop future computer systems that can better detect prostate cancer without invasive biopsies. This was a data-gathering step, not a treatment…

This study aimed to understand the lifestyle habits of people who have survived cancer, focusing on behaviors like smoking, drinking, diet, exercise, and sexual practices. Researchers surveyed 46 cancer survivors to identify which risky habits were common. The goal was to gather …

This study aimed to understand how chemicals formed when food is cooked (called AGEs) affect kidney function. Researchers tested 10 healthy young men by giving them meals either high or low in these chemicals, then using medical scans to measure changes in kidney blood flow and o…

This study aimed to find early signs that predict who will develop Post-Traumatic Stress Disorder (PTSD) after a recent traumatic event. Researchers followed 460 adults who visited the emergency room within a month of experiencing trauma, like a serious accident or violence. They…

This small study aimed to understand the connection between nerve sensitivity, skin blood flow, and the pain many people with psoriasis experience. Researchers measured how blood vessels in the skin of 20 patients with psoriasis reacted to certain substances, comparing a psoriasi…

This study aimed to understand how normal aging affects the heart muscle. Researchers used MRI scans and blood tests to measure heart function and look for signs of tissue scarring (fibrosis) in 74 healthy adults. The goal was to learn how these age-related changes are connected,…

This study tested a new automated system to see if it could grow cancer cells from patients with advanced metastatic cancer inside chicken eggs. The goal was to create a faster, cheaper research model to help scientists study cancer and test potential drugs. The study involved 10…

This study aimed to understand why people's performance changes when others are present, a phenomenon called 'social facilitation.' Researchers used brain scans (MRI) and eye-tracking to measure how 43 healthy young adults performed tasks alone versus while being observed. The go…

This study aimed to understand how smoking and drinking affect treatment for lung or head and neck cancer. Researchers followed 165 newly diagnosed patients to learn what makes it hard for them to quit and how that impacts their care. The goal was to gather information to help do…

This study aimed to understand why some patients with advanced skin cancer (metastatic melanoma) respond well to a type of immunotherapy called anti-PD1, while others do not. Researchers closely tracked changes in patients' immune cells before and during treatment. The goal was t…

This study aimed to understand how common and severe muscle loss is in people with chronic inflammatory arthritis. Researchers measured muscle strength, walking speed, and body composition in 106 patients during a single visit. The goal was to identify factors linked to muscle lo…

This study aimed to understand how specific areas in the front of the brain help control speech and facial movements. Researchers used MRI brain scans on 23 healthy, right-handed volunteers while they performed tasks. The goal was to map the brain's network for voluntary vocal an…

This study aimed to understand how children's reasoning abilities relate to their math skills by looking at brain activity. Researchers scanned the brains of 137 healthy children aged 8-14 while they solved reasoning problems, then compared this brain activity to their math test …

This study aimed to understand why some children with a rare genetic condition called Alpha-1 antitrypsin deficiency develop serious liver disease, while others do not. Researchers compared the genes of 296 children with the condition, focusing on those with and without liver com…

This study aimed to see if a special type of MRI scan could detect early changes in kidney function for people with medullary sponge kidney disease. Researchers compared MRI results from 33 adults with the disease to results from healthy adults. The goal was to learn more about t…

This study aimed to better understand why children with dyscalculia (a math learning disability) struggle with basic arithmetic. Researchers followed a small group of children aged 8-11 over three years, measuring how quickly and accurately they solved simple addition problems. T…

This study aimed to understand if a protein called periostin, found at high levels in the abnormal bone tissue of patients, could also be detected in their blood. Researchers measured periostin in 65 patients with fibrous dysplasia, a rare condition that weakens bones. They wante…

This study aimed to understand if digestion slows down during labor, which affects whether women should be allowed to eat. Researchers measured how quickly a light meal emptied from the stomach in four groups: women in labor with and without pain relief, pregnant women, and non-p…

This study aimed to understand why some Staphylococcus aureus pneumonia cases become very severe and deadly. Researchers followed 234 patients across France who were hospitalized with severe staph pneumonia. They collected data to see if a specific bacterial toxin (PVL) and a pat…

This study aimed to understand how our brains form and recall memories from realistic, everyday situations. Researchers had 95 healthy volunteers use smartphones in daily life or explore virtual reality environments to create memories. They then used brain scans and eye tracking …

This study followed 10 boys who had surgery to correct hypospadias, a common birth defect where the opening of the urethra is not at the tip of the penis. Researchers checked on their health after puberty to see how well the surgical repairs held up over the long term. They looke…

This study aimed to understand if probiotics could reduce harmful toxins produced by gut bacteria in people with advanced chronic kidney disease (CKD). Researchers collected stool samples from 20 patients with CKD and tested them in a lab-made artificial intestine. They measured …

This study aimed to understand how aging and dirt buildup affect the microphones in cochlear implants, which are devices that help people hear. Researchers tested 81 French-speaking adults with normal hearing to see how different sound processing methods in the implants performed…

This study aimed to better understand how Parkinson's disease affects the brain over time. Researchers used special brain scans (PET scans) to measure changes in two key chemical systems—dopamine and serotonin—in 49 people at different stages of Parkinson's. The goal was to see h…

This study aimed to understand the brain differences in people born with amusia, a condition where individuals have difficulty perceiving musical pitch. Researchers compared 230 French-speaking adults, some with amusia and some without, using brain scans and listening tests. The …

This study aimed to understand how a non-invasive brain stimulation technique works. Researchers used advanced brain scans on 37 healthy volunteers while applying a mild electrical current to the scalp. The goal was to map how this stimulation changes brain activity and chemistry…

This study aimed to understand how the human brain allows us to use and improve tools, a key ability in human evolution. Researchers used brain scans (fMRI) on 70 healthy volunteers while they performed tasks, including a challenge to build a tall tower from wire. The goal was to…

This study aimed to understand how severe medical events like septic shock, major trauma, burns, or surgery can weaken a patient's immune system. Researchers followed 552 adult patients and healthy volunteers, taking blood samples to measure immune function over time. The goal wa…

This study looked at whether continuous kidney dialysis causes temporary heart weakness in critically ill patients. Researchers monitored 42 patients with severe kidney injury who needed dialysis, using heart ultrasound scans to check for stress. The goal was to understand if thi…

This study aimed to better understand how the brain's wiring changes as people get older. Researchers used two types of advanced MRI scans on 10 healthy adults to create detailed maps of brain connections. The goal was to develop new ways to measure these connections, which could…

This study aimed to understand how a non-invasive brain stimulation treatment changes brain activity in people with chronic nerve pain. Researchers compared brain scans and measurements from 65 healthy volunteers and chronic pain patients before and after receiving magnetic brain…

This study aimed to understand how people with severe inner ear damage use very fast eye movements to keep their vision stable when moving their heads. Researchers compared 12 patients with this balance disorder to 12 healthy volunteers, measuring the timing and characteristics o…

This study collected blood samples from people with thyroid disorders to help standardize thyroid hormone tests. Researchers gathered samples from patients with different thyroid hormone levels to create reference materials. The goal is to make test results more consistent across…

This study aimed to see if a specific marker in a tumor (called MGMT) can predict which type of chemotherapy works better for patients with advanced neuroendocrine tumors. Researchers tested 116 patients to see if those with a 'methylated' MGMT marker responded better to one clas…

This study used a special type of MRI scan to see how blood flow changes in the aorta after a stent procedure for aortic dissection. Researchers scanned 5 patients before and after their treatment to measure blood movement in the repaired vessel and its branches. The goal was to …

This study aimed to find brain activity patterns that signal when people are becoming mentally or physically tired. Researchers measured brain waves in 169 healthy adults while they performed tasks designed to induce either mental fatigue or physical exhaustion. The goal was to i…

This study aimed to better understand why placing patients with severe Acute Respiratory Distress Syndrome (ARDS) in a face-down (prone) position helps them breathe. Researchers measured pressures inside the chest and lungs of 32 critically ill patients while they were on their b…

This study aimed to understand why brain cells die in people with BPAN, a rare genetic disorder that causes severe neurological problems and brain iron buildup. Researchers collected blood samples from 21 children and adults with BPAN to examine how their cells handle internal st…

This study aimed to discover which human proteins stick to hepatitis B virus particles. Researchers analyzed blood samples from 14 adults with high levels of the virus to identify these proteins. The goal was to understand how the virus uses these human proteins to survive and sp…

This study aimed to understand the risks of eye inflammation during pregnancy for women who were born with a parasitic infection called congenital toxoplasmosis. Researchers followed 76 women with this condition to see if pregnancy increased their risk of eye problems and to chec…

This study aimed to understand why some people who have had a stroke or mini-stroke (TIA) do not consistently take their prescribed prevention medications. Researchers followed 633 patients in France for one year after their stroke to track their medication use and identify facto…

This small study aimed to understand how the body absorbs and processes three different forms of the omega-3 fat DHA. Researchers gave specially labeled DHA to four healthy older men to track where it goes in the blood. The goal was to see if one form is better at delivering DHA …

This study aimed to understand why some people with drug-resistant epilepsy die suddenly without warning. Researchers monitored 1,072 patients to see if a severe drop in oxygen levels during or after a seizure could predict this risk. The goal was to gather information that might…

This study aimed to understand how the brain processes speech sounds in people with hearing loss or a specific language impairment. Researchers compared brain activity in 25 adults and children with these conditions to those with normal hearing. The goal was to identify differenc…

This study aimed to establish normal reference values for a specific blood clotting test (dRVVT) in healthy pregnant women. The goal is to help doctors better interpret test results to identify women at risk for serious pregnancy complications linked to abnormal blood clotting, s…

This study aimed to understand how the brain processes sound in people who are profoundly deaf and have received a cochlear implant in each ear. Researchers compared brain activity scans from 43 deaf adults with two implants to scans from people with normal hearing. The goal was …

This study tested a new way to set breathing machines for children during surgery and intensive care. Researchers measured the actual air reaching children's lungs to see if this gives better guidance than current methods. The goal was to gather information to help doctors use sa…

This study created a reference database of normal brain scans from 41 healthy adults. The goal is to help doctors better analyze brain images from people with epilepsy by comparing them to these healthy patterns. This could improve the accuracy of locating the source of seizures …

This study aimed to find a blood test that could identify epilepsy patients at risk for dangerous breathing problems during seizures. Researchers measured tiny molecules in the blood of 75 adults with hard-to-treat epilepsy and compared those who had low oxygen during seizures to…

This study aimed to understand how the brain uses sleep to strengthen skills learned through mental practice, like imagining a movement. Researchers measured brain activity in 51 healthy volunteers while they slept, after they practiced finger movement tasks only in their minds. …

This study aimed to understand how the human brain combines visual and auditory information to recognize gender. Researchers used MRI brain scans on 38 healthy volunteers while they performed a gender classification task. The goal was to map which brain areas are involved and see…

This study aimed to understand where the phosphate removed during dialysis comes from inside the body. Researchers used a special MRI scanner to measure phosphate and energy (ATP) levels inside the cells of 11 patients with kidney failure during their dialysis treatment. The goal…

This study aimed to understand how the immune system responds to COVID-19 over time. Researchers followed 189 adults who had a confirmed COVID-19 infection, checking their blood for antibodies at 6 months and 12 months after they got sick. The goal was to learn how long protectiv…

This study aimed to create a detailed map of the tiny nerve pathways inside the spinal cord. Researchers used a special type of MRI scan on 49 healthy volunteers to try to trace and identify these pathways. The goal is to build a reference atlas that could help doctors better und…

This study aimed to understand why some type 1 diabetes patients who receive a combined pancreas and kidney transplant still have blood sugar issues. Researchers measured changes in gut chemicals (bile acids), gut bacteria, and hormone levels in 50 transplant patients one year af…

This study tested a special type of MRI scan to see if it could reliably measure healthy hip cartilage. Researchers scanned 31 healthy volunteers twice in one session to check if the measurements were consistent. The goal is to gather baseline information that could help detect e…

This study aimed to understand how meditation and hypnosis affect brain activity and our sense of self. Researchers used brain scans (fMRI) on 100 healthy volunteers while they practiced these techniques. The goal was to map which brain areas become active during these altered st…

This research study compared different brain scanning methods to better identify where seizures start in people with drug-resistant epilepsy. Researchers simultaneously recorded brain activity using implanted electrodes along with MRI or MEG scans in 47 participants. The goal was…

This study aimed to find the best way to tell if a critically ill patient with severe lung failure (ARDS) needs more IV fluids while lying face-down. Researchers tested different measurements from heart monitors on 33 sedated patients to see which ones could accurately predict a …

This study aimed to understand how music and other sounds affect brain activity in people with severe consciousness disorders, like coma. Researchers measured brainwave responses in 86 participants, including both patients and healthy volunteers, when they heard familiar sounds l…

This study aimed to collect and store samples of gut bacteria from 14 patients with serious bone or joint infections. The patients were receiving a specific long-term antibiotic treatment given under the skin. The purpose was to create a collection for future research to see if t…

This study aimed to understand why some people with frontal lobe epilepsy have difficulty taking their medication as prescribed. Researchers compared 30 patients with healthy volunteers, having them play a cooperation game while their brains were scanned. The goal was to see if d…

This study aimed to understand how the brain learns to adjust our eye movements and process what we see. Researchers used MRI brain scans on 36 healthy volunteers while they performed simple eye-tracking tasks. The goal was to map which brain areas are involved in this learning p…

This study aimed to understand how the brain processes math problems. Researchers used MRI brain scans on 79 healthy children and adults while they solved arithmetic questions. The goal was to identify which specific brain areas become active during calculation and to see if this…

This small, completed study explored whether adding an ancient type of wheat called einkorn to people's diets could change the balance of bacteria in their mouths. Researchers measured bacteria linked to gum disease and general health markers in 31 healthy adults before and after…

This study aimed to find out if measuring pain sensitivity around a surgical scar two days after heart surgery could predict which patients would still have chronic pain three months later. Researchers used gentle filaments to map pain areas in 84 patients who had open-heart surg…

This study aimed to understand how COVID-19 spreads within hospitals. Researchers observed over 2,100 patients and healthcare workers who showed symptoms to identify patterns of infection. The goal was to gather information to help hospitals improve safety measures and protect bo…

This study aimed to find new markers in blood tests and heart scans that could better predict a patient's recovery and long-term risk of heart failure after a severe type of heart attack (STEMI). Researchers followed 281 patients who had a heart attack and received emergency trea…

This study aimed to understand how meditation practice affects the brain, attention, and emotion control. Researchers measured brain activity, stress markers, and task performance in 169 healthy adults. They used brain scans and simple computer tasks to look for connections betwe…

This study aimed to understand whether a steroid treatment (dexamethasone) given during pregnancy to prevent genital development issues in girls with congenital adrenal hyperplasia (CAH) affects children's thinking, memory, and emotions later in life. Researchers followed 354 chi…

This study aimed to understand why some staph bone and joint infections become chronic and hard to treat. Researchers examined tissue samples from 50 patients with these infections to see if the bacteria were hiding inside the body's own cells. The goal was to learn more about th…

This study aimed to understand the relationship between using certain stimulant drugs and compulsive sexual behavior (hypersexuality) in gay and bisexual men. Researchers surveyed 55 men who used drugs in sexual settings to see if the compulsive behavior was caused by the drugs o…

This study tested whether placing special electrodes on the brain's surface is safe and practical for monitoring patients with severe head trauma or brain bleeding. Researchers wanted to see if these electrodes could detect early electrical waves that signal new brain damage is s…

This study aimed to understand why painful, slow-healing leg ulcers are so common in adults with sickle cell disease. Researchers compared 70 adults with and without ulcers, measuring blood flow, nerve function, and substances in the blood and wound fluid. The goal was to learn m…

This study aimed to understand how children with cochlear implants locate sounds in three-dimensional space. Researchers used a virtual reality system to test 36 children, comparing those with implants to those with normal hearing. The goal was to gather knowledge to potentially …

This study explored whether combining mental practice with a safe, mild form of brain stimulation could help people learn complex finger movements. It involved 64 healthy young and older adults who practiced a finger sequence in their minds while receiving either real or fake sti…

This study aimed to understand how the body's inflammatory response after a heart attack relates to the amount of heart muscle damage. Researchers measured specific inflammation markers in the blood of 21 patients and compared them to detailed heart images from MRI scans taken a …

This study tested a common French belief that drinking a shot of Calvados brandy during a big meal helps with digestion. Eight healthy volunteers ate a large, high-calorie meal and had their stomach emptying measured with ultrasound. Researchers compared what happened when volunt…

This study aimed to understand why fibrous dysplasia, a rare bone condition, varies so much in severity between patients. Researchers looked for tiny genetic markers in the blood and bone tissue of 24 adults with the disease. The goal was to identify markers linked to more severe…

This study followed 331 people with cystic fibrosis in Europe for two years to understand their COVID-19 infection rates and immune responses. Researchers regularly tested blood samples for COVID-19 antibodies and tracked participants' health to see if infection affected their cy…

This study aimed to understand why people with sickle cell disease often have reduced physical fitness. Researchers compared leg muscle strength and fatigue during exercise between 77 sickle cell patients and healthy individuals. The goal was to determine if muscle dysfunction co…

This small study aimed to understand if and how the common skin bacteria Staphylococcus aureus (staph) triggers inflammation in people with eczema (atopic dermatitis). Researchers applied patches containing staph bacteria, its proteins, and a harmless skin bacteria to the skin of…

This study aimed to understand why people with multiple sclerosis (MS) experience long-term vision problems, known as chronic optic neuropathy. Researchers compared 39 MS patients with vision issues to healthy volunteers, using eye exams and brain scans to see if the damage was f…

This study aimed to find out if measuring a specific protein (IRAP) in the blood could be a simple way to check how sensitive a person's body is to insulin, which is important for blood sugar control. Researchers tested this idea in 21 healthy young adults by comparing the IRAP l…

This study aimed to find the best way to estimate a child's height when they are too sick in the intensive care unit to be measured standing up straight. Researchers tested several different estimation methods on 477 children against the standard World Health Organization measure…

This study aimed to understand why some people regain weight after gastric bypass or sleeve gastrectomy surgery. Researchers followed 45 patients for a year, using a special 3D scan to measure if their new, smaller stomach pouch stretched over time. They wanted to see if this str…

This study aimed to find a marker in the blood that could help doctors predict which flu patients in intensive care are most at risk of severe breathing failure or death. Researchers enrolled 227 adults and children hospitalized with confirmed flu and serious breathing problems. …

This study aimed to understand the genetic factors behind Combined Pulmonary Fibrosis and Emphysema (CPFE), a severe lung disease mostly affecting smokers. Researchers compared 250 people, including patients with CPFE, other lung conditions, and healthy individuals, to see if tho…

This study aimed to understand how brain injuries and migraines affect a person's ability to process sounds. Researchers tested 262 adults, including healthy volunteers, people with brain lesions, and people with migraines, using hearing tests, brain scans, and memory tasks. The …

This study tested a new scoring system called the SOFMER Activity Scale (SAS) to measure how well patients can perform daily physical and thinking tasks while in follow-up care or rehabilitation. Researchers enrolled 152 hospitalized patients to see if the score was accurate, rel…

This study aimed to understand how well standard vaccines work in adults who have received a stem cell transplant. Researchers followed 152 transplant recipients to measure their immune system's response to vaccines for diseases like tetanus, pneumonia, and hepatitis. The goal wa…

This study aimed to understand why some hip implants wear out faster than expected. Researchers examined tiny particles shed from implants in 55 patients to see which types cause the most inflammation. The goal was to gather knowledge to help improve future implant designs and lo…

This study aimed to find out why some people's blood pressure responds better to certain medications than others. It involved 139 adults with mild to moderate high blood pressure. Researchers tested different drugs and measured factors like diet, body size, and genetics to see wh…

This study aimed to understand why people feel groggy after waking from a nap, a state called 'sleep inertia.' Researchers used brain scans (fMRI) on 55 healthy adults before and after a 40-minute afternoon nap. They measured how different brain regions communicate to see if this…

This study aimed to understand why children with narcolepsy often gain weight and become obese. Researchers measured the metabolism, physical activity, and food intake of 24 children with narcolepsy over several days. The goal was to find the biological reason for the weight gain…

This study aimed to see if tracking cancer cells in the blood could help doctors better monitor patients with throat cancer. Researchers tested blood samples from 12 patients at different points in their treatment to see if changes in these cells could predict how well treatment …

This study aimed to understand how all the different symptoms of Hereditary Hemorrhagic Telangiectasia (HHT) affect patients' quality of life. Researchers surveyed 185 adult patients with HHT using a specialized questionnaire developed for this condition. The goal was to measure …

This study aimed to find better ways to adjust cochlear implants to help users understand speech in noisy environments like restaurants or parties. Researchers tested 28 adults, including people with normal hearing and long-term cochlear implant users. They measured how well peop…

This study aimed to understand if type 2 diabetes speeds up aging in the body, which might increase the risk of developing a specific heart muscle problem called diabetic cardiomyopathy. Researchers studied 150 middle-aged adults with well-managed type 2 diabetes but no current h…

This study aimed to better understand how the hepatitis C virus (HCV) works by identifying human proteins that stick to the virus particles. Researchers analyzed blood samples from 10 people with chronic HCV to see which human proteins the virus carries with it. The goal was to f…

This study aimed to find biological markers that could show if a person's body is naturally accepting a hand or face transplant. Researchers tested 18 patients who had received transplants at least one year prior, looking for specific immune system patterns. The goal was to learn…

This study aimed to understand why Crohn's disease often returns after surgery. Researchers followed 59 patients who had intestinal surgery for Crohn's, tracking their immune cells for one year. The goal was to find biological markers that could predict which patients are at high…

This study aimed to understand how people with a long-term loss of inner ear balance function might use very fast, automatic eye movements to see more clearly when they move their head. Researchers measured these quick eye movements and asked 20 patients about their vision proble…

This study aimed to understand why some fully vaccinated people still get COVID-19. Researchers analyzed over 1,000 vaccinated people who got infected to see if certain virus variants were more likely to cause these 'breakthrough' infections. They also measured how the immune sys…

This study aims to understand how babies' brains develop during their first year of life. Researchers will track 80 healthy infants at 3, 6, and 12 months using brain scans, eye tracking, and behavioral tests. The goal is to learn how early experiences shape brain development and…

This study aimed to better understand the heart muscle damage that can occur during open-heart surgery. Researchers used detailed heart MRI scans and tracked a specific blood protein (troponin) in 38 patients after their aortic valve surgery. The goal was to see if the blood test…

This study aimed to understand how having multiple chronic diseases affects the immune system in older adults. Researchers measured a specific immune marker in the blood of 81 hospitalized patients over age 75. The goal was to separate the effects of normal aging from the effects…

This study aimed to better understand the role of inflammation in age-related macular degeneration (AMD), a major cause of vision loss. Researchers collected fluid from the eyes of 82 patients during routine cataract surgery to measure specific inflammatory markers. By comparing …

This study aimed to find the best way to test if a patient in the ICU is ready to breathe on their own after being on a ventilator. Researchers compared two different ventilator settings used during a short breathing test. They measured how much effort it took patients to breathe…

This study aimed to understand how different specialized areas of the brain communicate to create thoughts and actions. Researchers used advanced brain scanning and gentle stimulation techniques on 157 healthy volunteers to test a theory about how brain waves help direct informat…

This study aimed to understand if children who survive a severe infection called septic shock develop a weakened immune system, similar to what happens in adults. Researchers measured immune markers in the blood of 105 children with severe shock and compared them to children havi…

This study followed 88 adults with moderate to severe traumatic brain injuries for 18 months. Researchers wanted to understand how hormone deficiencies might affect patients' quality of life and recovery. They measured hormone levels, thinking skills, and daily functioning to loo…

This early study tested a new radioactive tracer used in PET brain scans to measure serotonin 1A receptors, which are involved in mood and neurological function. It involved 20 healthy volunteers who underwent brain scans to see how well the tracer worked and if measurements were…

This study aimed to understand how the immune system changes in people with advanced melanoma who are receiving immunotherapy drugs (nivolumab with or without ipilimumab). Researchers closely monitored the immune cells in the blood and skin of 5 patients to identify differences b…

This study aimed to discover inherited genetic factors that might increase a person's risk of developing certain blood cancers, known as dysglobulinemias, which include multiple myeloma. Researchers studied families with at least two members who had one of these conditions. They …

This study aimed to understand why blood pressure readings can differ between the body's core and limbs during heart-lung bypass surgery. Researchers measured pulse waves in 40 patients undergoing scheduled heart surgery to see if this difference could be reliably detected. The g…

This study aimed to understand how the kidney medication dapagliflozin might work by looking at its effects on gut bacteria. Researchers observed 50 non-diabetic patients with chronic kidney disease who were starting this drug as part of their normal care. They checked if 12 week…

This study aimed to understand why some people get repeat C. difficile infections after treatment. Researchers measured the immune response in 56 hospitalized patients with confirmed C. diff diarrhea. The goal was to learn how the body's defenses relate to the risk of the infecti…

This study aimed to understand how common HPV infection and cervical cell changes are in women with cystic fibrosis. Researchers followed 85 women for two years, performing regular Pap smears and HPV tests. The goal was to gather data to improve gynecological care and screening g…

This study explored whether detailed eye scans could predict resistance in the small blood vessels of the heart. Researchers examined 101 adults with moderate coronary artery narrowing, taking measurements from both their heart arteries and their eyes. They used computer learning…

This study aimed to find better ways to program cochlear implants. Researchers measured electrical signals from the brain in 49 adult implant users to see if these signals could predict the best settings for comfortable hearing. The goal was to create models that might make the f…