Hospices Civils De Lyon

This study tested a special heart-protection plan given during cardiac surgery to see if it could reduce heart muscle damage compared to standard care. It involved 210 adults having aortic valve surgery at multiple French hospitals. Researchers measured a heart damage marker in b…

This study tested a drug called pasireotide in 57 adults with a bowel stoma (enterostomy) who were losing too much fluid despite standard treatments. The goal was to see if the drug could reduce fluid loss within 72 hours, helping patients avoid dehydration and hospital stays. Pa…

This study looked at kidney transplant patients who already had one skin cancer. It compared two groups: those who switched to the drug rapamycin and those who stayed on their usual anti-rejection medicines (calcineurin inhibitors). The goal was to see if rapamycin could help pre…

This study looked at people with rectal cancer that had spread to other parts of the body and could not be cured. It compared two treatments: having surgery to remove the main tumor followed by chemotherapy, versus chemotherapy alone. The goal was to see if surgery helped people …

This study looked at 82 adults getting a liver transplant to see if using a special blood test called ROTEM helps doctors manage bleeding better than standard tests. The goal was to reduce the amount of blood products given during surgery. Researchers also checked for serious com…

This study looked at 141 men with Klinefelter syndrome (47,XXY) to see if younger men (ages 15–22) have a better chance of finding sperm through testicular biopsy compared to older men (ages 23–55). Participants provided semen samples, and if none were found, they underwent a bio…

This study looked at 78 adults with advanced kidney failure who needed a surgical connection between an artery and vein (fistula) for dialysis. It compared two ways to numb the arm during surgery: a nerve block near the armpit versus local anesthesia with sedation. The goal was t…

This study tested whether using a special bag during laparoscopic surgery to remove uterine fibroids or the uterus can prevent the spread of cells that might be cancerous. 48 women were randomly assigned to have the procedure with or without the bag. The main goal was to see if f…

This study looked at 279 adults with idiopathic pulmonary fibrosis (IPF) whose disease was getting worse despite treatment. It compared taking two drugs together (pirfenidone and nintedanib) versus switching to the other single drug. The goal was to see which approach better slow…

This study tested a special nursing strategy to prevent pressure sores (bedsores) in patients with severe lung failure who need to lie face-down. It included 160 adults in intensive care. The approach focused on checking and protecting key body areas like the forehead, chest, and…

This study tested a blood-filtering treatment called plasma exchange in 21 adults with severe COVID-19 and breathing problems. The goal was to remove harmful inflammatory substances from the blood to improve lung function and reduce the need for a breathing tube. Researchers comp…

This study looked at 346 kidney transplant patients to see if a biopsy taken 3 months after surgery could help doctors better manage anti-rejection drugs. Patients with mild signs of rejection were given extra treatment, while those with no inflammation had their steroids reduced…

This study tested whether adding a drug called pegylated interferon to the standard treatment nilotinib helps people with newly diagnosed chronic myeloid leukemia (CML) achieve a deeper molecular response. 200 adults under 65 took part. The goal was to see if the combination lead…

This study tested whether a gentle brain stimulation technique called tDCS can help people with schizophrenia whose symptoms don't fully improve with medication alone. 141 participants received either real or fake (placebo) stimulation over 5 days. The goal was to see if the real…

This study tested whether minoxidil, a blood pressure medicine, can improve blood vessel health in children with Williams-Beuren syndrome, a rare genetic condition that often causes heart and artery problems. The trial included 21 children aged 6 to 18 who took either minoxidil o…

This study compared two treatments for people with Barrett's esophagus who have high-grade dysplasia, a precancerous condition. One treatment is surgery to remove part of the esophagus, which has serious risks. The other is a newer, less invasive procedure called radiofrequency a…

This study tested two different chemotherapy combinations (R-ACVBP and R-CHOP) along with the targeted drug rituximab in 222 adults aged 18-59 with an aggressive type of B-cell lymphoma. Participants had 2 or 3 risk factors that make the disease harder to treat. The researchers u…

This study tested whether methotrexate works as well as cyclosporine for adults with moderate to severe eczema. One hundred participants received one of the two drugs for 24 weeks. The main goal was to see how many people had a 50% improvement in their eczema symptoms after 8 wee…

This study tested if somatostatin, a drug that lowers blood pressure in the liver, can prevent dangerous fluid buildup after liver cancer surgery. 179 patients with liver cancer and underlying liver disease took part. The goal was to see if the drug reduces the need for drainage …

This study looked at whether a personalized 6-month home walking program could reduce dangerous bleeding inside neck artery plaque in 56 patients who had significant blockages but were not having surgery. Participants either wore a step counter with monthly step goals or received…

This study tested a new way to place dental implants in the upper jaw when there isn't much bone. Instead of doing a sinus lift (a common bone-building surgery), doctors used a special image-guided system to place implants more precisely. The study included 60 adults who needed i…

This study tested whether a single injection of cyclosporine, given right before opening a blocked artery, could improve outcomes for people having a major heart attack. About 970 patients received either cyclosporine or a placebo. Researchers tracked deaths, hospitalizations for…

This study looked at how different types of small brushes for cleaning between teeth (interdental brushes) affect gum health in young adults aged 18 to 30. The goal was to see if brushes that are sized to fit each person's gaps (calibrated) work better than one-size-fits-all brus…

This study compared two types of albumin dialysis (MARS and SPAD) in 34 people with severe liver failure. Both treatments filter toxins from the blood when the liver cannot. The goal was to see which one removes bilirubin better and is easier to use. Results help doctors choose t…

This study tested whether eating foods with extra fiber, polyphenols, omega-3, and slow-digesting starch for 9 weeks could reduce low-grade inflammation in 62 adults with abdominal obesity and cardiometabolic risk. Participants ate either fortified or standard foods, and research…

This study tested a high-precision radiation technique called stereotactic radiotherapy on 13 people with small kidney tumors (4 cm or less). The goal was to find the highest safe dose that can destroy the tumor while protecting healthy tissue. Participants received 4 to 5 radiat…

This study tested two different chemotherapy combinations as follow-up treatment (consolidation) in younger adults (ages 18-59) with newly diagnosed acute myeloid leukemia (AML) who achieved remission after initial therapy. The goal was to see which regimen better prevents the ca…

This study looked at whether a program including geriatric checkups, pain management, weekly Tai Chi, and vitamin D supplements could help women over 70 with breast cancer stick to their hormone therapy. The program aimed to improve treatment compliance and reduce side effects. O…

This study tested a drug called bevacizumab in 25 adults with hereditary hemorrhagic telangiectasia (HHT) who had severe liver blood vessel problems and high cardiac output. The goal was to see if the drug could improve heart function and avoid the need for a liver transplant, wh…

This study tested whether giving the immunotherapy drug nivolumab directly into the abdomen is safe after extensive surgery and heated chemotherapy for advanced ovarian cancer. 22 women with recurrent ovarian cancer took part. The goal was to find the highest safe dose and see if…

This study tested a device called Cavaterm™ to treat heavy menstrual bleeding in 20 women who did not respond to medication. The treatment uses a balloon to remove the lining of the womb in a short outpatient procedure. The goal was to see if symptoms improved two months after tr…

This study tested the drug olaparib in 35 adults with a specific type of aggressive brain tumor (IDH-mutant high-grade glioma) that had returned after standard treatments. The drug works by taking advantage of a weakness in the tumor cells' ability to repair their DNA. The main g…

This study tested if a growth hormone (rhGH) could help children with short bowel syndrome reduce or stop their need for IV nutrition. Fourteen children aged 3-18 who had been on IV nutrition for at least 3 years took part. The results will show if the hormone helps them absorb m…

This study tested hand transplants in 7 people who lost both forearms. The goal was to see if the brain could adapt to the new hands and improve daily life. Participants had to take lifelong anti-rejection medication, so this is a disease control approach, not a cure.

This study tested a device called MitraClip that clips a leaky heart valve to help it close better. 304 people with severe mitral regurgitation and heart failure were randomly assigned to get either standard care alone or standard care plus the MitraClip procedure. The goal was t…

This study tested a special medical glue (IFABOND) to hold mesh in place during laparoscopic surgery for pelvic organ prolapse. The goal was to see if using glue instead of staples or stitches reduces problems like mesh erosion. 70 women with severe prolapse took part, and the st…

This study looked at whether a stem cell transplant from a matched donor could help younger myeloma patients (under 65) who had already responded well to their first transplant. The goal was to improve how long patients lived without the disease getting worse. Patients received a…

This study tested whether naloxone, a drug that reverses opioid overdoses, could help people with epilepsy breathe better after a severe seizure. About 485 adults with drug-resistant epilepsy were monitored in the hospital. Those who had a generalized tonic-clonic seizure receive…

This study tested a technique called postconditioning in 44 people having a first heart attack. After opening the blocked artery with a balloon, doctors briefly inflated and deflated the balloon a few times to see if it would reduce damage to the heart muscle and improve blood fl…

This study looked at two ways to treat unruptured brain aneurysms (bulging blood vessels) that haven't bled. One method uses tiny coils to block the aneurysm, and the other uses a special stent to divert blood flow away from it. Researchers compared how well each method worked, t…

This study tested a drug called avelumab in 24 women with a rare pregnancy-related cancer (GTN) that did not respond to standard chemotherapy. The goal was to see if the drug could lower their tumor marker (hCG) to normal levels. Avelumab works by helping the immune system attack…

This study looked at 120 women over 70 with advanced ovarian cancer who were considered vulnerable due to age and health. It compared three chemotherapy plans: standard two-drug therapy, a single drug, or a weekly low-dose combination. The goal was to see which plan allowed patie…

This study tested a combination of three drugs (cyclophosphamide, metformin, and olaparib) in 35 women with advanced or metastatic endometrial cancer that had come back after standard chemotherapy. The goal was to find the safest dose and see if the combination could stop the can…

This study tested whether adding bevacizumab to standard chemotherapy (Folfiri) helps people with advanced neuroendocrine carcinoma live longer after their first treatment stops working. The trial included 153 adults with aggressive, inoperable cancer. The main goal was to see ho…

This study tested a technique called remote ischemic conditioning in 180 adults with septic shock. The approach involves briefly inflating and deflating a blood pressure cuff on the arm to protect organs from damage. The goal was to see if this simple procedure could reduce the s…

This study looked at whether the standard vitamin D supplement (cholecalciferol) helps children with chronic kidney disease, kidney transplants, or nephrotic syndrome reach healthy vitamin D levels. 43 children took a single high-dose vitamin D vial, and researchers measured thei…

This study compared two types of weight-loss surgery for people with severe obesity: the standard Roux-en-Y gastric bypass and a newer Omega Loop bypass. Researchers wanted to see which surgery is safer and works better for weight loss. The trial involved 256 adults aged 18 to 65…

This study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 adults who had a heart transplant at least a year ago and had recurring skin cancers took part. The goal was to see if switching to everolimus w…

This study tested whether a drug called GM-CSF can reduce new infections in ICU patients whose immune system is weakened after severe sepsis or septic shock. 166 adults were randomly given either GM-CSF or a placebo. The goal was to see if the drug could lower the number of hospi…

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…

This study tested a new way of using breathing machines in 220 adults with severe COVID-19 lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. Participants were randoml…

This study looked at whether cutting a small ligament on the outside of the knee (lateral retinaculum release) is helpful during a common surgery for recurrent kneecap dislocation. The surgery, called MPFL reconstruction, already tightens the inner ligament to keep the kneecap in…

This study tested if placing patients with severe acute respiratory distress syndrome (ARDS) on their stomachs (prone position) for at least 16 hours a day could lower the chance of dying. 474 adults on breathing machines were randomly assigned to either prone or standard (face-u…

This study compares two types of weight-loss surgery for people with severe obesity: a newer procedure called SADI-S and the standard RYGB. Researchers want to see if SADI-S leads to greater weight loss after two years. About 382 adults aged 18-65 with a BMI of 40 or higher (or 3…

This study tested a new device called Lina Librata that uses a balloon to destroy the lining of the uterus in women with heavy menstrual bleeding. The goal was to see if it could stop periods and be done with local anesthesia in an outpatient setting. 38 women aged 40-50 who did …

This study tested a new way to help surgeons remove glioblastoma, an aggressive brain tumor. Patients drank a special liquid (5-ALA) before surgery that makes tumor cells glow, helping surgeons see and remove more of the cancer. The study compared this glowing technique to the st…

This study looked at how safe the drug cabozantinib is for adults with advanced liver cancer (HCC) who had already tried another drug called sorafenib. A total of 110 participants were followed to track side effects and overall survival. The goal was to see if cabozantinib can be…

This study looked at whether a technique called angioplasty postconditioning can reduce heart muscle damage in people having a heart attack. It included 72 adults whose blocked heart artery had already started to reopen on its own before the procedure. The goal was to see if brie…

This study tested whether regular nurse counseling could help teenagers with type 1 diabetes feel better about managing their disease and improve blood sugar control. 77 teens aged 13-18 with poorly controlled diabetes took part. One group received extra nurse calls and monthly v…

This study tested a treatment called focused ultrasound (HIFU) for men with intermediate-risk prostate cancer. The goal was to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. 174 men participa…

This study tested a special machine that pumps cold, oxygen-rich fluid through donor livers just before transplant. The goal was to see if this method reduces early liver damage after surgery compared to the usual cold storage. The trial included 266 adults receiving a first live…

This study tested a method to keep fluid levels neutral in 65 critically ill patients with acute kidney injury who were on continuous kidney replacement therapy. The approach used advanced heart monitoring to match fluid removal to fluid intake, aiming to prevent dangerous fluid …

This early-phase study tested a treatment for cancer that has spread to the lining of the abdomen (peritoneal carcinosis). Doctors surgically removed visible tumors and then washed the abdomen with heated chemotherapy drugs (mitomycin C and irinotecan). The goal was to find safe …

This study tested two imaging techniques—Histoscanning™ and multiparametric MRI—to see how well they can find prostate cancer that comes back after radiation therapy. Thirty men with signs of recurrence had both scans, followed by targeted and random biopsies to check accuracy. T…

This study looked for better ways to diagnose late-onset sepsis in newborns at least 7 days old in the NICU. Researchers tested combinations of blood markers to see which could accurately rule out infection early. The goal is to reduce unnecessary antibiotic use, which can cause …

This study looked at whether a newer, more detailed swallowing test (high resolution manometry) can better diagnose the cause of swallowing difficulty (dysphagia) in people whose standard endoscopy was normal. 247 adults with unexplained dysphagia took part. The goal was to see i…

This study looked at whether ultrasound can accurately detect a full stomach in patients lying flat versus sitting up at a 45-degree angle. The goal is to prevent a rare but dangerous complication where stomach contents enter the lungs during anesthesia. 21 healthy adults partici…

This study tested whether quickly removing a small amount of fluid during dialysis can help predict if a patient needs more fluids. Twenty critically ill adults with acute kidney injury on continuous dialysis took part. Researchers compared two speeds of fluid removal to a standa…

This study looked at whether a new ultra-low dose CT scanner can find lung blood vessel malformations in people with HHT (a genetic disorder) as accurately as a standard low-dose CT, but with far less radiation. 45 patients were scanned with both methods. The goal is to reduce ra…

This study tested a new device called DiCART that automatically measures how quickly blood returns to the skin after pressing it (capillary refill time). Doctors use this test to check blood flow in seriously ill patients, but current methods vary a lot between observers. The stu…

This study tested whether using MRI to guide prostate biopsies finds more aggressive cancers than the usual ultrasound-guided method. 275 men with suspected prostate cancer had both types of biopsies. The goal was to see if MRI-targeted biopsies detect more high-grade (Gleason 7 …

This study tested whether a cone-beam CT scanner (often used for dental imaging) can detect cartilage damage in the wrist, ankle, elbow, and knee as well as a standard multidetector CT scanner. 69 adults who needed an arthroscan (a CT scan after dye injection into the joint) were…

This study looked at 7 different blood markers to see if they can better tell apart severe bacterial infections from viral infections in children aged 7 days to 36 months with fever. Researchers enrolled 983 children and compared the new marker combination to standard tests like …

This study tested whether measuring knee looseness during an MRI can help doctors better diagnose partial tears of the anterior cruciate ligament (ACL), which are often hard to see on standard scans. Researchers followed 151 people with knee injuries for one year to compare the n…

This study tested whether a combined PET/MRI scan using a radioactive tracer can better locate tiny pituitary tumors that cause Cushing's disease. Standard MRI often misses these tumors, leading to invasive tests or risky surgery. The study involved 33 adults with confirmed Cushi…

This study tested whether a step-by-step diagnostic plan for uveitis (eye inflammation) works as well as letting doctors choose tests freely, while costing less. Over 900 adults with uveitis took part. The goal was to see if the standardized approach could find the cause of uveit…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage 8 common health problems (like pneumonia, kidney stones, and pregnancy concerns) without needing extra tests. Over 160 patients took part, and researchers compar…

This study tested a non-invasive eye ultrasound to detect high brain pressure in 230 children with brain injuries. The goal was to see if measuring the optic nerve sheath diameter could replace the standard invasive monitoring. Results could lead to safer, faster detection in int…

This study tested a new tool that uses special light to help surgeons see brain tumors more clearly during surgery. Eleven adults with suspected brain tumors took part. The goal was to see if the tool could tell the difference between tumor types and healthy tissue, which could l…

This study looked at whether measuring a substance called BD glucan in the belly fluid of ICU patients with peritonitis can diagnose fungal infections faster than standard lab tests. The standard method takes at least 48 hours, which can delay life-saving treatment. The study enr…

This study tested whether a cone-beam CT scanner, typically used for dental imaging, can accurately detect and classify fractures in the arms and legs. 43 adults with suspected fractures received both a standard CT and the cone-beam CT. Researchers compared how well the cone-beam…

This study tested a special mouth splint (BRUXENSE) to see if it can help diagnose sleep bruxism (teeth grinding). Seven adults with bruxism wore the splint for 10 nights. The goal was to see if the splint is comfortable enough to use and can collect enough data for a diagnosis.

This study tested whether a simple, non-invasive stomach ultrasound can accurately detect dangerous fluid levels in children before anesthesia. 92 healthy children aged 1-10 drank different amounts of clear liquid, then had their stomachs scanned. The goal was to see if the ultra…

This study tested two new tools to make tuberculosis (TB) skin tests better. Researchers compared a new, easy-to-use needle against the standard method and tried a non-invasive scanner to read the results. The goal was to see if these tools could make TB testing simpler and more …

This study tested a program to help women over 50 get proper care for osteoporosis after a low-impact wrist or upper arm fracture. Half of the women received extra information and reminders about osteoporosis, while the other half got usual care. The goal was to see if the progra…

This study tested whether giving the anti-seizure drug levetiracetam right after a brain bleed (hemorrhagic stroke) could prevent seizures and improve recovery. About 50 adults with a recent brain bleed were randomly assigned to receive levetiracetam or a placebo for 48 hours. Th…

This study tested a program to prevent falls in elderly patients staying in hospital. Over 1,800 people aged 65 and older took part. The program involved a team of healthcare workers teaching patients how to identify fall risks, prevent falls, and get up safely after a fall. The …

This study tested whether a program combining exercise and education could help healthcare workers avoid repeat episodes of lower back pain. Over 350 workers with a history of back pain took part, and researchers tracked sick leave and pain for two years. The goal was to see if t…

This study looked at how long women with Factor V Leiden or Factor II mutations should take blood thinners after giving birth to prevent dangerous blood clots. Researchers compared treatment lasting less than 2 weeks versus 6 weeks in 86 women. The goal was to see if shorter trea…

This study looked at whether prazosin, a drug normally used for high blood pressure, could prevent post-traumatic stress disorder (PTSD) in people who recently experienced a traumatic event like an accident or assault. Researchers gave the drug to 15 adults who showed signs of ac…

This study tested a care pathway for adults over 70 who showed early signs of mobility trouble. Participants received personalized exercise coaching and nutritional counseling to prevent loss of mobility. The goal was to see if this approach could help them maintain strength, bal…

This study tested a new virtual reality training program designed to help adults with two cochlear implants improve their ability to locate where sounds are coming from. Twelve adults who have had their second implant for at least a year took part in up to eight rehabilitation se…

This study tested whether adding gentle electrical pulses to leg muscles during stationary cycling helps people who survived severe COVID-19 regain movement faster. Twenty-two adults who had been on breathing machines in the ICU took part. Researchers measured how much time they …

This study tested a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for people with chronic, severe tinnitus (ringing in the ears). 64 adults received either real or fake magnetic pulses to see if it could reduce the loudness of their tinnitus an…

This study looked at whether bringing in a supportive and palliative care team early can improve quality of life for adults with acute leukemia that has returned after initial treatment. 49 patients were split into two groups: one received early, standardized supportive care, whi…

This study looked at two methods to control pain after total knee replacement: a nerve block in the thigh (adductor channel block) and injecting numbing medicine around the knee joint (periarticular infiltration). The goal was to see which one reduces the need for morphine and he…

This study tested whether playing on an electronic tablet can reduce anxiety in children before outpatient surgery better than the standard medicine, midazolam. 118 children aged 4 to 10 were randomly assigned to receive either the tablet or the drug. Their anxiety levels were me…

This study looked at whether a personalized, supervised exercise program could help children and teens (ages 6-18) with osteogenesis imperfecta, a rare condition that causes fragile bones. Over one year, 30 participants followed an adaptive physical activity plan designed to be s…

This study looked at whether regular cycling during dialysis sessions can improve blood flow to the legs in people with chronic kidney disease. 27 adults on long-term hemodialysis pedaled for 30 minutes each session over three months. The goal was to see if this simple exercise c…

This study tested whether injecting botulinum toxin (Botox) into the lower esophagus can help people with nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either Botox or a placebo in a double-blind setup. The main goal …

This study tested a drug called tocilizumab for people with fibrous dysplasia of bone who still had pain after standard treatment. The drug blocks a protein linked to bone damage. Nineteen adults took part in this small, early-stage trial to see if the drug could reduce bone pain…

This study tested if a non-invasive brain stimulation technique called tDCS can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 people, including both healthy volunteers and patients with long-term nerve pain. The goal was to see if targeting a…

This study tested whether showing patients a live ultrasound image of their tongue during speech therapy helps them improve faster. It included 18 adults who had surgery for mouth or throat cancer and children with brain damage. Patients did standard therapy sessions both with an…

This study tested whether a short educational session before outpatient orthopedic surgery helps patients manage their pain better at home. About 412 adults scheduled for day surgery took part. The goal was to see if teaching patients about pain and how to use painkillers properl…

This study tested a program called PROADAPT for older adults with cancer who were about to have surgery. The program included gentle exercise, nutrition advice, education, and medication check-ups to help prevent weakness and complications. 148 patients took part to see if this k…

This study tested whether a handgrip exercise program before and after surgery could help dialysis fistulas grow larger and work better. 40 adults with advanced kidney disease who chose hemodialysis participated. The goal was to see if exercise could reduce the high failure rate …

This study tested two different arm exercise methods in 26 people who had a stroke and had trouble using one arm. One method used intentional, focused movements, while the other aimed to trigger more automatic, natural movements. The goal was to see which approach better improved…

This study tested whether trained peer counselors—mothers who successfully breastfed their own preterm babies—could help other mothers of preterm infants breastfeed longer. Over 1,700 mothers and babies from 8 hospitals in Europe took part. Counselors provided weekly face-to-face…

This study tested a new virtual reality training program designed to help people with hearing loss improve their ability to locate where sounds are coming from. Researchers enrolled 79 adults, including those with hearing loss and those with normal hearing. Participants practiced…

This study looked at whether placing infants under 6 months with severe bronchiolitis on their stomach (prone position) reduces the effort needed to breathe. Sixteen babies on breathing support were randomly placed face-down or face-up, and their breathing work and lung pressure …

This study looked at whether gabapentin and memantine can reduce the rapid, involuntary eye movements (pendular nystagmus) that some people with multiple sclerosis experience. Ten adults with MS and chronic eye shaking for at least 6 months took part. Researchers measured eye mov…

This study tested whether removing only the sentinel lymph node (the first node cancer might spread to) is as safe as removing many pelvic lymph nodes in women with early cervical cancer. 267 women took part. The goal was to see which approach causes fewer complications and how i…

This study looked at two common treatments for Osgood-Schlatter disease, a painful knee condition in growing teens. Researchers compared wearing a leg cast for a few weeks versus simply resting from sports. The goal was to see which approach helped more teens return to full sport…

This study looked at whether injecting botulinum toxin into two leg muscles (rectus femoris and semitendinosus) can improve walking and reduce stiffness in children with cerebral palsy. Twenty-three children aged 7 to 17 who could walk (with or without aids) took part. Researcher…

This study tested two different pain relief medicines given through a small tube near the spine after video-assisted lung surgery. 90 adults took part to see if adding sufentanil to ropivacaine reduces pain better than ropivacaine alone. The main goal was to measure how much morp…

This study tested whether hearing aids could improve thinking, behavior, and quality of life in people with mild to moderate Alzheimer's disease who also have hearing loss. 51 participants were split into two groups: one got active hearing aids right away, the other started with …

This study looked at whether giving lidocaine through an IV during and after ear, nose, and throat cancer surgery can lower the need for strong painkillers (opioids) and reduce long-term pain. 143 adults having major head and neck cancer surgery took part. Researchers measured ho…

This study looked at whether foot reflexology can help reduce nausea and vomiting caused by chemotherapy in people with lung or digestive cancer. Eighty patients received either reflexology or standard care. The goal was to see if the foot massage made a difference in how sick th…

This study tested a temporary urethral stent in 9 men with spinal cord injury who had trouble emptying their bladder due to a condition called detrusor sphincter dyssynergia. The stent is placed under local anesthesia and can be removed later, offering an alternative to permanent…

This study looked at 66 adults with knee osteoarthritis who needed a partial knee replacement. It compared the usual manual surgery to a robotic-assisted method to see which gives better leg alignment and function. The goal is to improve how well the knee works and how long the i…

This study looked for the best dose of a medicine called ephedrine to treat low blood pressure in newborns and infants up to 6 months old during surgery. Low blood pressure is common in these young patients under anesthesia and can be harmful. The study tested different doses of …

This study looked at whether women with severe vaginal prolapse can have surgery and go home the same day. 38 women were treated at three hospitals, and researchers tracked how many were successfully discharged on the same day, why some couldn't, and how satisfied they were. The …

This study tested whether applying estrogen cream to the penis daily for two months before surgery could reduce complications like fistulas (abnormal openings) and wound separation in 244 boys with severe hypospadias, a birth defect where the urethra doesn't form properly. The bo…

This study tested a 5-month mindfulness meditation program for 108 hospital workers to see if it could improve their mental well-being at work. Participants were compared to a control group that did not receive the program. The goal was to see if this simple, non-drug approach co…

This study looked at whether gabapentin and memantine can reduce the constant back-and-forth eye movements (nystagmus) in people with oculopalatal tremor, a condition caused by brainstem damage. Seven adults took each drug separately, and researchers measured eye movement speed a…

This study tested whether placing infants under 6 months old with moderate to severe bronchiolitis on their stomachs (prone position) while using a high-flow nasal cannula could reduce the need for more intensive breathing support like CPAP or a ventilator. Researchers compared t…

This study looked at how symptoms change after a procedure called Bulkamid injection for stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). The treatment is a gel injected around the urethra to help it close better. The study included 70 women who…

This study looked at whether wearing a custom compression garment (a tight vest) can reduce shoulder pain and improve joint stability in people with hypermobile Ehlers-Danlos syndrome, a condition that causes loose joints and chronic pain. About 48 adults wore the vest for 4 week…

This study tested whether melatonin can improve sleep quality in autistic children aged 3 to 12 who have sleep problems. Researchers measured nighttime awakenings using sleep tests and questionnaires. The goal was to find the most effective dose of melatonin to help these childre…

This study looked at whether CFTR modulator drugs improve nose and sinus symptoms in children aged 6 to 11 with cystic fibrosis. Researchers measured quality of life using a special questionnaire before and one year after starting treatment. The goal was to see if these drugs hel…

This study looked at whether a specific type of surgery for pelvic organ prolapse, called anterior sacrospinofixation using the patient's own tissue, improves symptoms. The study included 66 women with moderate to severe prolapse. The main goal was to see how many women felt thei…

This study tested whether clonidine, a drug used for high blood pressure, can help reduce impulse control disorders (like gambling or overeating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The goal was to see if clonidi…

This small pilot study tested a non-invasive device that gently stimulates the vagus nerve through the skin. Ten women with Irritable Bowel Syndrome (IBS) used the device daily for six months. The goal was to see if it could improve digestive symptoms, reduce inflammation, and en…

This study tested whether a simple ear acupuncture treatment could lower anxiety in women waiting for a planned cesarean section. 91 pregnant women received either a tiny needle patch, a needle-free patch, or no patch on their ear. Researchers measured their anxiety levels before…

This study followed 3 children aged 8–11 with dyscalculia (a math learning disability) for 3 years. Researchers watched how fast they solved simple addition problems to see if their counting skills became automatic over time. The goal was to better understand the root cause of th…

This study looked at how different types of feedback (like social or monetary) affect decision-making in 76 healthy adults. Researchers used brain scans and a mild stimulation technique to understand which brain areas are involved. The goal is to apply this knowledge to help peop…

This study looked at 98 children with a symptomatic discoid lateral meniscus (a thicker, C-shaped knee cartilage). Doctors checked if an uneven ability to bend the knee could signal a dislocated meniscus. They found that this simple exam finding may help identify a specific type …

This pilot study looked at whether giving intravenous immunoglobulins (IVIG) to children with toxic shock syndrome is practical and promising. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The study enrolled 30 children in intensive care to see if a lar…

This study looked at 85 women with cystic fibrosis to find out how many carry the HPV virus, which can lead to cervical cancer. Researchers checked for HPV and abnormal cervical cells using a Pap test and DNA testing. The goal is to help doctors better understand the need for reg…

This study looked at how children's brains process deductive reasoning and how that relates to their math skills. Researchers used fMRI scans to measure brain activity in 137 children aged 8 to 14 while they solved reasoning problems. They then compared that activity to math test…

This study aimed to establish normal reference values for a blood clotting test called dRVVT in pregnant women. Researchers measured dRVVT levels in 100 women with normal pregnancies to help doctors better diagnose antiphospholipid syndrome, a condition that increases clot risk d…

This study looked at a new method to set breathing machines for children under anesthesia. Instead of using a fixed breath size, researchers measured the air that actually reaches the lungs (alveolar ventilation) using a special device. The goal was to find a steady target that k…

This study looked at why people perform differently when others are around. Researchers measured brain activity and eye movements in 43 healthy adults aged 18-35 while they did tasks alone or with someone watching. The goal was to find the hidden mental process that causes this '…

This study looked at how well the ReVive™ SE device works to restore blood flow in people having a stroke caused by a blocked artery. Only one patient took part, and the goal was to see if the device helped improve blood flow to the brain. The study did not change the patient's r…

This study looked at healthy adults to see how smoking and drinking affect gene changes in the mouth lining that could lead to oral cancer. Researchers checked for specific mutations in mouth cells from 100 participants, comparing smokers and non-smokers. The goal was to better u…

This study looked at the safety of giving lidocaine (a numbing medicine) during weight-loss surgery. 50 adults having laparoscopic bariatric surgery had their blood tested at several points to measure lidocaine levels. The goal was to confirm that dosing based on a modified body …

This study measured vitamin C levels in 100 elderly people (over 65) living in long-term care units. Researchers wanted to find out how common vitamin C deficiency is and what factors might increase the risk. Participants gave a blood sample and had a skin exam to check for signs…

This study tested whether MRI can measure blood flow changes in the aorta before and after a stent procedure for aortic dissection, a serious tear in the artery wall. Five patients who needed non-emergency stent surgery had two MRI scans to compare blood flow in the true and fals…

This study looked at 12 people with chronic bilateral vestibular hypofunction (a balance disorder causing blurry vision during head movement) and 12 healthy volunteers. Researchers measured how quickly and often the eyes make tiny, automatic saccades during head turns to see if t…

This study looked at why people with frontal lobe epilepsy sometimes don't take their medication as prescribed. Researchers used a simple economic game (the prisoner's dilemma) and brain scans to compare cooperative behavior between 30 epilepsy patients and healthy volunteers. Th…

This study looked at 25 people with a single copy of a mutated AGXT gene, which is linked to a rare kidney stone disease. Researchers compared those who had kidney stones or kidney damage with those who did not, to find out what factors—like diet or lifestyle—might trigger sympto…

This study looked at how a non-invasive brain stimulation technique called tDCS changes brain activity and chemistry in 37 healthy adults. Researchers used advanced brain scans to see the effects during and after a single 30-minute session. The goal is to better understand how tD…

This study looked at 10 adults with chronic hepatitis C to find proteins attached to the virus particles. Researchers purified virus from blood samples and identified these proteins to learn how the virus infects cells and makes copies of itself. The goal was to discover new targ…

This study looked at 11 adults with acute respiratory distress syndrome (ARDS) to see if their body position (lying flat at 0° or slightly raised at 30°) changes the accuracy of esophageal pressure measurements used to set ventilators. Researchers measured pressure at both angles…

This study looked at 100 people who had a transient ischemic attack (TIA) and were treated in emergency rooms in Lyon, France. Researchers wanted to see how much patients understood about their condition, including risk factors, symptoms, and what to do if symptoms return. The go…

This study looked at 182 people who already had advanced AMD in one eye and intermediate AMD in the other. Researchers used a special test called microperimetry to measure light sensitivity and eye fixation, aiming to see if it could predict when the intermediate eye would progre…

This study aims to better understand how the brain's connections change as people age. Ten healthy volunteers aged 18 to 50 underwent special MRI scans to map their brain networks. The researchers developed new markers to measure these connections, which could help future studies…

This study looked at 49 adults with cochlear implants to see if electrical signals from the inner ear can help predict the best device settings. Researchers measured these signals during surgery and after months of use, comparing them to hearing tests and patient details. The goa…

This study tested whether special electrodes placed on the brain can detect early warning signs of new damage in patients with severe head injury or brain bleeding. Twenty patients in intensive care had these electrodes placed alongside standard monitoring. The goal was to see if…

This study looked at 20 adults who had NMDA receptor encephalitis, a rare brain disease that can cause severe symptoms like seizures and memory loss. Researchers wanted to understand how the disease affects people's social lives, emotions, and daily functioning years after the ac…

This study looked at 33 adults with ARDS (a serious lung condition) who were lying on their stomachs (prone position) and needed fluids. Doctors wanted to see if certain heart measurements could predict whether a patient would benefit from extra fluids. The goal was to find a rel…

This study looked at how sickle cell disease affects leg muscles. Researchers compared muscle strength and fatigue in 77 people with and without sickle cell disease during a short exercise. The goal was to understand if muscle problems contribute to poor physical fitness in sickl…

This study looked at how the immune system changes after serious events like septic shock, severe trauma, burns, or major surgery. The goal was to confirm that many patients enter a state of immune suppression, which raises the risk of dangerous secondary infections. Researchers …

This study looked at whether continuous kidney replacement therapy can cause temporary heart muscle weakness (myocardial stunning) in critically ill patients with severe acute kidney injury. Researchers observed 42 adults to see if heart function changes during treatment. The goa…

This study measured inflammation markers in the blood of 21 people who had a heart attack and compared them to heart damage seen on MRI scans. The goal was to understand how the body's inflammatory response relates to the size and type of heart injury. This research did not test …

This study tested a new scale called the SOFMER Activity Scale (SAS) to measure how much help patients need with physical and mental activities during rehabilitation. Researchers enrolled 152 patients in follow-up care and rehab departments. The goal was to see if the scale is ac…

This study looked at how pancreas-kidney transplants change bile acids and blood sugar control in people with type 1 diabetes and kidney disease. Researchers measured bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transplant patien…

This study looked at how the brain combines information from faces and voices to decide a person's gender. Researchers used brain scans (fMRI) on 38 healthy adults while they performed a gender classification task. The goal was to understand which brain areas are involved and whe…

This study examined tissue samples from 50 patients with staph bone or joint infections to see if the bacteria can hide inside human cells. Researchers used special staining to find intracellular staphylococci and identify which cell types they occupy. The goal was to better unde…

This study looked at how symptoms of Hereditary Hemorrhagic Telangiectasia (HHT) impact quality of life. Researchers used a special questionnaire created by and for HHT patients. 185 adults took part to help doctors better understand which symptoms matter most.

This study examined over 1,000 vaccinated adults who later caught COVID-19. Researchers analyzed the virus's genetic code and measured antibody levels to see if certain variants were more common in these cases. The goal was to understand why infections still happen after vaccinat…

This study looked at 25 adults in the ICU with moderate to severe acute respiratory distress syndrome (ARDS). The goal was to test a new, simple way to measure if airflow is blocked when they breathe out. Researchers compared results in different body positions and at different b…

This study tested whether bedside ultrasound can accurately measure muscle loss in critically ill children, compared to the gold-standard MRI. Researchers enrolled 35 children in the pediatric ICU who already needed an MRI. The goal was to see if ultrasound could be a reliable, e…

This study looked at 143 patients who had phalloplasty surgery to create a penis. The goal was to understand how the surgery affected their quality of life, sexual function, and overall satisfaction. Researchers used surveys to compare patients' experiences before and at least on…

This study aimed to create a simple questionnaire that can predict whether someone has low vitamin D levels, without needing a blood test. Over 2,500 adults aged 18 to 70 took part. The goal was to save money and make it easier to identify people who might need vitamin D suppleme…

This study looked at brain activity in 169 healthy adults to find patterns that predict mental and physical tiredness. Using non-invasive EEG and MEG scans, researchers measured how the brain responds during tasks that cause fatigue. The goal was to better understand fatigue mark…

This study looked at whether a telephone interview or video call after a stroke patient goes home can help them better understand and stick to their medication plan. 54 adults who had an ischemic stroke and were returning directly home took part. Researchers checked their knowled…

This study looked at how the brain, especially the cerebellum, helps coordinate eye movements with what we see and pay attention to. Researchers tested 24 people, including healthy adults and those with cerebellar disease, by measuring how their eyes adapted to visual tasks. The …

This study tracked 289 healthcare workers in short-stay hospital wards to find out how often they catch the flu, even without symptoms. Researchers compared flu rates between vaccinated and unvaccinated workers. The goal is to better understand the risk of unknowingly spreading f…

This study looked at 32 people with advanced melanoma who were treated with the immunotherapy drug Nivolumab (Anti-PD1). The goal was to understand how the immune system changes during treatment and why some patients respond well while others do not. By analyzing blood samples be…

This study collected stool samples from 20 people with advanced chronic kidney disease (CKD) to test whether probiotics can reduce harmful uremic toxins. The researchers used an artificial intestine to compare toxin levels with and without a probiotic supplement. The goal is to f…

This study looked at how the heart's muscle stiffness (fibrosis) changes as people age normally. Researchers used MRI scans and blood tests to measure fibrosis in 74 healthy adults. The goal was to better understand age-related changes in heart function, not to treat any disease.

This study tested whether giving a small amount of fluid (3 ml per kg over 2 minutes) can predict if a child under anesthesia will need more fluids. 60 children having scheduled surgery took part. The goal was to avoid giving too much fluid, which can be harmful. The approach was…

This study aims to understand why people with high blood pressure respond differently to various medications. Researchers will look at factors like diet, body size, genetics, and hormone levels. 139 adults with mild to moderate high blood pressure will take several different drug…

This study measured inflammation-related proteins in the eye fluid of 82 people with different stages of age-related macular degeneration (AMD) and a control group without AMD. The goal was to identify specific markers that might explain why some forms of AMD progress faster and …

This study collected brain PET scans from 41 healthy adults aged 20-65 to create a reference database. Doctors can compare these normal scans to those of epilepsy patients to more precisely locate where seizures start. The goal is to improve surgical outcomes for people with epil…

This study looked at which parts of the brain are active when doing math. 79 healthy right-handed children (ages 8-14) and adults (ages 18-24) had their brains scanned with functional MRI while doing arithmetic. The goal was simply to understand normal brain activity, not to test…

This study looked at how dapagliflozin, a drug already used for kidney disease, changes the gut bacteria in people with chronic kidney disease who do not have diabetes. Researchers measured gut bacteria diversity and related toxins in the blood before and after 12 weeks of treatm…

This study tested whether imagining a finger movement (motor imagery) combined with a gentle electrical current to the brain (tDCS) could improve learning of a complex finger sequence. 64 healthy young and elderly adults participated. The goal was to see if this combination boost…

This study followed 255 women with gestational diabetes to see if a blood test during pregnancy could predict who will develop type 2 diabetes after giving birth. Researchers measured three markers in the blood and checked glucose tolerance three months after delivery. The goal i…

This study looked at how the COVID-19 virus spreads within hospitals among patients, caregivers, and healthcare workers. Over 2,100 people from several hospitals took part. The goal was to find out who gets infected, why, and how to better protect everyone with improved hygiene a…

This study tested a new automated method to grow cancer cells from patients with metastatic cancers (like prostate, breast, lung) inside chicken eggs. The goal was to see if this system could successfully grow tumors from patient samples, which could help doctors study cancer and…

This study looked at 98 critically ill adults who had trouble coming off a ventilator. It compared two methods of a breathing test: one using a T-piece alone, and another combining pressure support with positive end-expiratory pressure. The goal was to see which approach helped p…

This study followed 88 adults who had a moderate or severe traumatic brain injury (TBI) to see if hormone deficiencies affect their quality of life over time. Researchers measured quality of life and thinking skills up to 18 months after the injury. The goal was to better underst…

This study tested a new radioactive tracer called [18F]-F13640 to see how well it can image certain brain receptors (5-HT1A) using PET scans. Twenty healthy volunteers took part to check how the tracer moves in the body and if the results are repeatable. The goal was to improve b…

This study looked at how cochlear implant microphones change as they age or get dirty, and whether different signal coding strategies can help. Researchers tested 81 people with normal hearing to measure how well they recognized syllables. The goal was to understand microphone we…

This study tested a new type of eye training for people who lost part of their vision after a stroke or brain injury. Unlike older methods that require a lot of effort, this approach uses automatic eye movements to help patients look into their blind area. The goal was to see if …

This study looked at how common muscle loss (sarcopenia) is in people with spondyloarthropathy, a type of inflammatory arthritis. Researchers measured muscle strength, walking speed, and body composition in 106 adults aged 18 to 80. The goal was to better understand and detect th…

This study looked at brain waves in 108 women to see if the brain activity of obese women with eating disorders resembles that of people with addiction. Researchers measured brain responses to sounds using EEG. The goal was to understand the cognitive processes behind overeating,…

This study enrolled 5 people with advanced melanoma who were starting treatment with nivolumab (with or without ipilimumab). Researchers took blood and skin samples to track how immune cells changed during therapy, aiming to spot differences between those who responded to treatme…

This study looked at 250 people to understand why some smokers develop a rare combination of lung scarring and emphysema (CPFE syndrome). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only scarring or only emphysema, and healthy volu…

This study looked at 65 people with fibrous dysplasia, a rare bone disease that can cause pain and fractures. Researchers measured a protein called periostin in the blood to see if it is higher in patients with more severe disease. The goal was to learn if a simple blood test cou…

This study collected gut bacteria samples from 14 patients with bone or joint infections who were receiving long-term antibiotic injections under the skin. The goal was to build a sample collection for future research on whether antibiotic resistance develops. No treatments or re…

This study looked at 47 people with Hereditary Hemorrhagic Telangiectasia (HHT) who also have liver involvement. The goal was to see if measuring blood pressure in the lungs during exercise could catch early signs of heart failure that standard resting tests miss. Researchers com…

This study looked at 84 adults who had open-heart surgery through a chest cut (sternotomy). Two days after surgery, researchers used thin nylon filaments to map areas of increased pain sensitivity around the scar. They then checked if those patients still had pain three months la…

This study looked at 39 people with multiple sclerosis who have ongoing vision issues. Researchers wanted to understand if the vision loss is caused by damage to the nerve coating (demyelination) or by the nerve cells dying off (degeneration). Participants had eye exams, scans, a…

This study looked at how psoriasis affects blood flow and nerve sensitivity in the skin. Twenty adults with psoriasis on their back took part. Researchers measured skin blood flow and nerve responses on both psoriasis plaques and healthy skin to understand the link between nerves…

This study looked at how people with congenital amusia (tone deafness) process sound and memory compared to those without it. Researchers used brain scans like EEG, MEG, and MRI to measure brain activity during listening and memory tasks. The goal was to better understand the bra…

This study looked at how doctors move their hands and fingers when inserting a small tube (catheter) into a vein. Researchers measured the forces on the skin and vein, the angle of the needle, and how hard the doctor pressed to find the vein. The goal was to gather data to build …

This study looked at how Staphylococcus aureus (staph) bacteria, commonly found on eczema-affected skin, might cause disease flares. Researchers applied staph bacteria or their toxins to the skin of 7 people with eczema and healthy volunteers to see if it triggers inflammation. T…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol levels. Researchers measured the density of a protective pigment in the macula (part of the eye) to see if it is linked to low levels of carotenoids and vitamins. The goal was to better un…

This study looked at 116 people with advanced neuroendocrine tumors (NETs) to see if a marker called MGMT can predict which chemotherapy works best. Researchers compared two chemo types—alkylating agents and oxaliplatin—based on the tumor's MGMT status. The goal is to personalize…

This study used PET scans to measure alpha2-adrenergic receptors in the brains of 16 healthy men. The goal was to test how well the imaging method works and whether a single dose of clonidine can block the tracer. It was a phase 1 study focused on understanding the technique, not…

This study looked at two ways to do knee replacement surgery: one where the kneecap is resurfaced with a plastic implant, and one where it's left natural. Researchers followed 250 patients for 12 months after surgery to see which method led to better knee function and fewer probl…

This study used MRI scans to measure how fingertips bend and shift when pressed or rubbed. Eight healthy adults had their index fingers scanned while light forces were applied. The goal was to collect data to create realistic computer models of the finger, which could help improv…

This study looked at how a 40-minute afternoon nap affects connections between brain regions involved in daydreaming and self-awareness. Researchers scanned the brains of 55 healthy adults before and after napping to see if these connections weakened. They also compared people wh…

This study looked at how brain damage (from strokes or injuries) and migraines affect the way people process sounds, including attention, memory, and emotions. Researchers tested 262 adults using hearing tasks and brain scans like EEG and MRI. The goal was to better understand th…

This study involved 49 healthy volunteers to test whether a special MRI technique can clearly show the different nerve pathways in the spinal cord. The goal was to create a detailed atlas of these pathways, which could help doctors better understand and treat spinal cord injuries…

This completed study surveyed 55 men who have sex with men who use psychoactive substances, particularly synthetic cathinones, during sex. Researchers used questionnaires to determine whether hypersexual behaviors are pre-existing or induced by the drugs. The goal was to better u…

This study tested a special microscope called Cellvizio that lets doctors see inside the fallopian tubes during surgery. The goal was to find early, precancerous changes that might lead to ovarian cancer. 40 women having their fallopian tubes removed for various reasons took part…

This study looked at how meditation affects attention and emotions by scanning the brains of 169 healthy adults. Researchers used MRI and EEG to measure brain activity and stress markers. The goal was to understand the science behind meditation's benefits for mental well-being.

This study looked at 20 adults in the ICU who were on breathing machines for acute respiratory failure. Researchers compared two methods of helping them breathe on their own: a low-pressure support mode and an automatic tube compensation mode. The goal was to see which method bet…

This study looked at whether special cells in the blood, called circulating tumor cells (CTCs), can help predict if oropharyngeal cancer will come back. Researchers took blood samples from 12 patients at different times to measure these cells. The goal was to see if CTCs could be…

This study looked at whether children with severe infectious shock develop immune suppression, similar to what is seen in adults. Researchers measured immune markers in 105 children admitted to intensive care and compared them to healthy children having surgery. The goal was to u…

This study looked at tiny particles that wear off hip implants in 55 adults who had hip replacement surgery. Researchers used special microscopes to examine these particles in joint fluid and tissue. The goal was to understand which types of particles cause the most inflammation …

This study looked at 154 older adults (70+) having hip fracture surgery. It compared a special low-dose spinal anesthesia with general anesthesia to see which one keeps blood pressure more stable during the operation. The goal is to reduce heart complications after surgery.

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation using brain scans and electrical recording…

This study followed 165 adults newly diagnosed with lung or head and neck cancer to understand how their smoking and drinking habits influenced their treatment. Researchers collected information on social factors, addiction levels, and barriers to quitting. The goal was to find b…

This study looked at how the human brain handles tool use and tool improvement. Researchers used brain scans (fMRI) on 70 healthy adults to see which brain areas are active when using tools. The goal was to understand what makes human tool use special, like our ability to make to…

This study tested whether a detailed eye exam could predict how well blood flows in the heart's small arteries. Researchers measured blood flow in the heart and eyes of 101 people with coronary artery disease. They used machine learning to see if eye scans could replace invasive …

This study looked at how two brain chemicals, dopamine and serotonin, change over time in people with Parkinson's disease. Researchers used special PET scans to compare early, middle, and late-stage patients, as well as healthy volunteers. The goal was to better understand non-mo…

This study tested whether an automated closed-loop system could manage intravenous fluids better than an anesthesiologist during high-risk abdominal surgery. 46 adults undergoing major abdominal procedures were randomly assigned to either the automated system or standard care. Th…

This study looks at how a medicine called dexamethasone, given during pregnancy to prevent a rare hormone disorder (congenital adrenal hyperplasia), might affect children's thinking and memory. Researchers will compare children who received the drug with those who did not, includ…

This study looked at how three different forms of DHA (an omega-3 fat) are processed in the body. Four healthy men aged 60-70 took labeled DHA, and researchers measured its levels in blood cells and plasma after 6 hours. The goal was to find which form might best reach the brain.

This study looked at 46 people with severe obesity who had either gastric bypass or sleeve gastrectomy. Researchers used a special CT scan with gas to measure stomach volume 3 and 12 months after surgery. The goal was to see if an enlarged stomach pouch is linked to weight regain…

This study looked at 24 adults with fibrous dysplasia, a rare bone disease that causes pain, fractures, and deformities. Researchers wanted to find out if small molecules called microRNAs in the blood and bone tissue are linked to how severe the disease is. They compared samples …

This study looked at genetic differences in children with alpha-1 antitrypsin deficiency, a rare inherited condition that can cause liver disease. Researchers compared children who had liver problems with those who did not, to find gene patterns that might predict severe liver da…

This study looked at cells from the umbilical cords of 16 newborns who had a parent with hereditary hemorrhagic telangiectasia (HHT), a rare disorder that causes abnormal blood vessels and bleeding. Researchers grew these cells in the lab to compare their genes with cells from he…

This study surveyed 46 cancer survivors in France to find out how many have unhealthy habits like smoking, drinking, poor diet, or lack of exercise. The goal was to see if a custom screening could help prevent future diseases. The research is complete and focused on understanding…

This study looked at how brain scans (fMRI and MEG) relate to electrical signals recorded directly from the brain (intracranial EEG) in people with epilepsy and healthy volunteers. The goal was to better identify the area causing seizures and map healthy brain networks to avoid d…

This study looked at how the brain processes sound in 43 deaf adults who have two cochlear implants, comparing them to people with normal hearing. Researchers used brain scans to see if the timing between getting each implant affects how the brain handles sound from both ears. Th…

This study looked at whether listening to familiar or favorite music can improve brain responses in people with consciousness disorders after a coma, as well as in healthy volunteers. Researchers measured brain waves to see if music helps the brain process personal information li…

This study looked at 65 people with cystinosis to see how well they take their cysteamine medicine and if that affects brain problems. Researchers measured drug use with special bottle caps and diaries, and used brain scans and memory tests to check for cystine buildup. The goal …

This study looked at 189 adults who had COVID-19 to see how long their antibodies last. Researchers collected blood, saliva, and nose swabs at 6 and 12 months after infection. The goal was to understand the immune response and whether protective antibodies persist over time.

This study looked for a substance in the blood (called HLA-G5) that might help doctors predict which flu patients in the intensive care unit (ICU) are at higher risk of severe breathing problems or death. Researchers studied 227 adults and children with severe flu. They also coll…

This study looked at 38 adults who had heart surgery to understand the damage that happens to the heart muscle during the procedure. Researchers used heart MRI scans and blood tests (troponin levels) to measure and compare the amount of injury. The goal was to better understand t…

This study looked at whether using a bedside lung ultrasound in the emergency department for patients with shortness of breath can lower the risk of death or return to the hospital within 3 months. About 385 adults with breathing trouble were included. The goal was to see if this…

This study tested a special brain scan (PET/MRI) in 15 children aged 5 to 17 with tumors at the back of the brain. The goal was to see if the scan is practical and gives clear images. The results may help doctors better understand different tumor types before surgery.

This study looked at how the brain keeps our eye movements accurate, even as we grow or change. Thirty-six healthy adults had their brains scanned with MRI while performing special eye-tracking tasks. The goal was to identify which brain areas are involved in adjusting eye moveme…

This study looked at how platelets (a type of blood cell) change over time in people who had a brain aneurysm bleed. The goal was to better understand why some patients later develop delayed brain injury. Researchers compared 90 patients with aneurysm bleeds to those with other t…

This study looked at whether drinking a small amount of Calvados (a strong apple brandy) during a rich meal helps the stomach empty faster. Eight healthy adults ate a high-calorie meal and either had Calvados with sorbet or water with sorbet. Researchers used ultrasound to measur…

This study looked at whether people with cystic fibrosis (CF) have natural protection against COVID-19. Researchers tested blood samples from 331 children and adults with CF in Europe over two years to see if they had antibodies from past infection or vaccination. The goal was to…

This study followed 1,100 adults with severe obesity who were taking the weight-loss drug WEGOVY®. Researchers tracked weight changes over 12 months and looked for patterns in who lost the most weight. They also used artificial intelligence to find clues—like certain health marke…

This study looked for signs of immune tolerance in 18 people who received hand or face transplants at least one year earlier. Researchers tested blood and skin samples for markers that might show which patients could safely lower their anti-rejection medications. The goal is to r…

This study collected blood and tissue samples from over 2,100 patients with digestive peritoneal carcinomatosis (cancer that has spread to the lining of the abdomen). The goal was to create a large, high-quality biobank for future research into why some cancers resist treatment. …

This study looked at why some people get C. difficile infections again after treatment. Researchers measured the immune response in 56 hospitalized adults with confirmed C. diff diarrhea. The goal was to see if certain immune factors are linked to a higher chance of relapse.

This study collected MRI and 3D ultrasound images from 2 men who had their prostate removed due to cancer. The goal was to create a database that researchers can use to develop a computer system that spots tumors without needing a biopsy. The study did not test any treatment or d…

This study looked at how different parts of the brain talk to each other. Researchers used brain scans and mild electrical stimulation to test a theory about brain waves. 157 healthy adults took part. The goal was to understand normal brain communication, not to treat any disease…

This study looked at how cochlear implants help people understand speech in noisy places. Researchers tested 28 adults (some with normal hearing, some with implants) to measure how different implant settings affect word recognition in background noise. The goal is to customize im…

This study tested whether a coordinated care plan, supported by an electronic system shared among patients and healthcare providers, could improve how well pregnancy checkups and exams are completed. Over 1,500 pregnant women in France took part. The goal was to see if this organ…

This study used special MRI scans to learn more about medullary sponge kidney, a rare condition that causes cysts in the kidney tubes and can lead to kidney stones. Researchers compared 33 adults with the disease to healthy controls to see if MRI could detect early changes in kid…

This study followed 633 people who had a stroke or mini-stroke to understand why some stop taking their medicines that prevent another stroke. Researchers checked pharmacy and prescription records and called participants after one year. The goal was to identify social, medical, a…

This study looked at how the body breaks down wheat bran fiber in 6 healthy women. Participants ate special biscuits made with labeled wheat bran, and researchers measured the fiber's byproducts in breath, urine, blood, and stool over 24 hours. The goal was to find new markers th…

This study collected blood samples from 28 adults with thyroid disorders to help make thyroid-stimulating hormone (TSH) tests give the same results no matter which lab runs them. Currently, different labs use different tests, leading to confusion for doctors and patients. By anal…

This study looked at why hospitalized children aged 2 to 8 eat less, focusing on food pickiness and neophobia (fear of new foods). Researchers measured how much food children ate 48 hours after admission and asked parents about their child's usual eating habits. The goal was to s…

This study aimed to find out how often people come to the emergency room because of the flu, even when the flu isn't listed as the reason. Researchers tested over 2,400 adults visiting the ER during flu season to see how many actually had the flu. The results will help hospitals …

This study looked at 11 people with end-stage kidney disease to understand where phosphate removed during dialysis comes from. Using a special MRI technique, researchers measured phosphate and energy (ATP) levels inside cells during a 4-hour dialysis session. The goal was to see …

This study looked at whether being in labour slows down how fast the stomach empties a light meal. Researchers used ultrasound to measure stomach size in 43 women: those in labour with or without epidural, pregnant women not in labour, and non-pregnant women. The goal is to help …

This study looked at over 1,000 people with drug-resistant partial epilepsy to find out if dangerous drops in oxygen during seizures can predict sudden unexpected death (SUDEP). Researchers monitored patients in a hospital setting to track these oxygen dips and other risk factors…

This study looked at how chemotherapy changes taste and smell in 69 people with digestive cancers. Researchers tracked changes in food preferences and eating habits after the first round of chemo. The goal was to understand why some patients struggle with nutrition during treatme…

This study followed 281 people who had a severe type of heart attack (STEMI) to find new biological and imaging markers that could help predict recovery and future heart problems. Participants gave blood samples and had MRI scans to track heart damage and healing. The goal was to…

This study looked at whether tiny molecules in the blood, called microRNAs, can help identify epilepsy patients who have dangerous drops in oxygen during seizures. Researchers monitored 75 adults with drug-resistant epilepsy during long-term video-EEG and compared those who had b…

This study looked at whether the ADHD rating scale can measure changes in attention problems in children with epilepsy. Researchers followed 173 children aged 6 to 15 with both epilepsy and ADHD. The goal was to see if the scale is sensitive enough to use in future treatment stud…

This study looked at why people with sickle cell disease get leg ulcers. Researchers measured blood flow and nerve function in 70 adults with and without ulcers. They also checked blood and wound fluid for clues. The goal was to better understand the problem, not to test a new tr…

This study looked at why children with narcolepsy often gain weight and become obese. Researchers measured the total energy burned over 24 hours in 24 children with narcolepsy or hypersomnia, both at home and in the hospital. The goal was to see if a change in metabolism explains…

This study looked at how cells from people with BPAN (a rare genetic brain disorder) handle stress. Researchers collected blood samples from 21 children and adults with BPAN to measure how well their cells recycle damaged parts (autophagy) and respond to stress. The goal was to b…

This study looked at how healthy people remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI to understand which parts of the brain are involved in recalling memories. The goal was to learn more about memory and attention, n…

This study looked at 32 adults with severe lung failure (ARDS) who were on breathing machines. Researchers measured pressure inside the lungs when patients were lying on their back versus on their stomach (prone position). The goal was to see if stomach-lying changes lung pressur…

This study aims to find normal oxygen pressure values in the upper arm and determine what level indicates severe artery disease. Researchers measured oxygen in 39 healthy volunteers and reviewed past patient records. The goal is to create a standard test for diagnosing upper limb…

This study looked at 1,000 adults aged 40-80 with type 2 diabetes or obesity to find the best way to screen for advanced liver scarring (fibrosis) caused by fatty liver disease. Researchers tested combinations of blood tests and a special ultrasound (FibroScan) to improve accurac…

This study looked at how sleep helps the brain solidify motor skills that were learned through mental imagery (imagining movements without actually doing them). Researchers used brain scans to track changes in brain activity before and after sleep. The goal was to understand whic…

This study looked at a specific serotonin receptor (5-HT4) in the brains of people with mild to moderate Parkinson's disease compared to healthy volunteers. Using PET scans, researchers measured receptor levels and checked how they relate to movement, thinking, and mood symptoms.…

This study looked at whether adding a brain MRI and a check by a nerve doctor (neurologist) changes the treatment plan for people with a serious heart valve infection called infectious endocarditis. About 29 adults with this infection took part. The goal was to see if these extra…

This study looked at the genes and immune systems of 271 children and adults with lupus, a chronic autoimmune disease. The goal was to find genetic mutations linked to lupus, especially in children or those with a family history. Researchers hope this will lead to a better unders…

This study looked at how hard newborns with a hole in their diaphragm (congenital diaphragmatic hernia) have to work to breathe after surgery. Researchers compared a standard ventilator with a newer type called NAVA, which uses the baby's own breathing signals to provide support.…

This study looked at how changes in mouth sensations—like touch, temperature, and texture—affect food preferences in people with head and neck cancer. Researchers compared 72 patients to healthy volunteers using a simple pressure test and temperature sensitivity measures. The goa…

This study looked at whether a protein called IRAP, found in the blood, can be used as a marker for insulin sensitivity (how well the body uses insulin). Researchers measured IRAP levels in 21 healthy adults during a special test called a hyperinsulinemic-euglycemic clamp, which …

This study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease more dangerous. Researchers tracked survival, hospital stays, and genetic factors. The goal was to better understand why some cases are so severe, not to test a new treatm…

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used brain scans, EEG, and eye tracking to understand how babies develop skills like moving, socializing, and thinking. The goal was to learn more about normal…

This study looked at whether eating einkorn, an ancient cereal, could change the types of bacteria in the mouth. Researchers focused on bacteria linked to gum disease and cancer risk. Thirty-one healthy adults added einkorn to their usual diet, and their mouth bacteria were measu…

This study tested whether a special nutrition team and electronic alerts could help hospital staff follow best practices for caring for malnourished children. Over 1,400 children and their healthcare providers took part across multiple hospital units. The goal was to see if bette…

This study looked at 59 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers tracked changes in certain immune cells (T cells) in the blood and gut over one year to see if they could predict when the disease would come back. The goal…

This study used brain scans (fMRI) to understand how two specific brain areas help control speech. 23 healthy, right-handed adults performed tasks while their brain activity was measured. The goal was to learn more about these brain networks, which could one day help improve spee…

This study looked at two methods doctors use to decide how to treat people with multiple blocked heart arteries. One method used standard X-ray images, while the other added a special pressure wire test (FFR) to see which blockages truly need treatment. Over 900 adults with stabl…

This study tested whether a special PET/MR scan can detect which carotid artery plaques are more likely to cause a stroke. Fifteen people with at least 50% narrowing of the carotid artery took part—half had a recent stroke and half did not. Researchers measured how much of a radi…

This study looked at whether people with type 2 diabetes who show signs of premature aging are more likely to develop heart muscle disease. Researchers measured aging markers in blood and used heart imaging in 150 adults aged 40-55 with diabetes but no heart symptoms. The goal wa…

This study looked at 76 women with congenital toxoplasmosis to see if pregnancy raises the risk of eye inflammation (retinochoroiditis). Researchers used past and current medical records from a French hospital cohort. The goal is to better inform women about their eye safety duri…

This study looked at 50 adults who had jaw surgery to fix an anterior open bite (a gap between front teeth). Researchers wanted to see if tongue rehabilitation (retraining tongue position) after surgery helped prevent the gap from coming back. The goal is to improve long-term suc…

This study looked at 20 people with long-term balance problems that cause blurry vision when moving their head. Researchers wanted to see if fast, unconscious eye movements called covert-saccades help them see better. Participants took vision and quality-of-life tests to measure …

This study looked at whether a special MRI scan (T1rho) can reliably measure hip cartilage in 31 healthy adults. The goal is to find normal values and see if the measurements are consistent. This could help doctors detect early signs of hip osteoarthritis before symptoms start.

This study looked at 14 adults with chronic hepatitis B to find human proteins that stick to the virus. The goal was to better understand how the virus works and identify new targets for future treatments. Researchers purified virus particles from blood samples and used mass spec…

This study collected blood samples from nearly 1,900 people in families where at least two members had a blood disorder called dysglobulinemia, which includes multiple myeloma and related conditions. The goal was to identify genetic differences that might increase the risk of dev…

This study looked at fat tissue in 23 men with advanced chronic kidney disease (stage V) who were not on dialysis and did not have diabetes. Researchers took small samples of belly fat during surgery to measure fat cell size and study gene activity. The goal was to understand how…

This study looked at whether certain compounds in cooked food, called AGEs, change how the kidneys work. Ten healthy young men ate either a high-AGE meal (chicken nuggets) or a low-AGE meal (eggs), and researchers measured kidney blood flow and oxygen levels using special scans. …

This study followed 230 people with cystic fibrosis to understand why some develop diabetes that can get better or worse. Researchers looked at genetics, lung health, and infections to find clues. The goal is to improve how doctors screen for and treat diabetes in cystic fibrosis…

This study tested whether taking 4.5 grams of chitin-glucan fiber daily for three weeks could improve gut bacteria and related health markers in 19 adults with abdominal obesity and cardiometabolic risk. Researchers measured changes in gut bacteria, fatty acids, and digestion. Th…

This study looked at 460 adults who came to the emergency room after a traumatic event, like a serious injury or threat of death. The goal was to find out which factors—biological, psychological, and social—can predict if someone will develop post-traumatic stress disorder (PTSD)…

This study looked at how well recommended vaccines work in 152 adults who had a stem cell transplant. After transplant, the immune system is weak and past protection against infections is lost. Researchers measured antibody levels after full vaccination to see if the body builds …

This study aimed to understand how meditation and hypnosis affect our brain's sense of self. Researchers used brain scans (fMRI) on 100 healthy volunteers while they practiced mindfulness and hypnosis techniques. The goal was to identify which brain areas become active during the…

This study looked at how the brain processes speech sounds in people with language impairment or hearing loss. Researchers measured brain responses to syllables in 25 participants to find differences between the two groups. The goal was to better understand the root causes of spe…

This study tested a program where a specially trained nurse helps elderly patients (75+) transition from hospital to home. The goal was to see if this support reduces the chance of being readmitted or visiting the emergency room within 30 days. 630 patients took part, and the pro…

This study looked at a specific immune marker (mHLA-DR) in 81 elderly patients over 75 with multiple chronic conditions. The goal was to understand how aging and having several illnesses together affect the immune system. Researchers measured mHLA-DR levels in the blood to gather…

This study looked at 40 heart surgery patients to understand why blood pressure readings can differ between the body's center and arms during use of a heart-lung machine. Researchers measured pulse wave speed at the thigh, upper arm, and wrist to find a better way to detect these…

This study looked at how children aged 8 to 17 with two cochlear implants perceive where sounds come from in three-dimensional space. Using virtual reality and motion tracking, researchers measured how accurately the children pointed to sound sources. The goal was to understand t…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their hearts were working before giving them extra fluids. The goal was to…

This study looked at whether removing the fallopian tubes during a hysterectomy for non-cancer reasons affects a woman's ovarian reserve (egg supply). It involved 96 women and compared two surgical techniques: using electric energy versus ultrasound. The goal was to gather knowle…

This study looked at 10 males who had surgery for hypospadias (a birth defect where the urine opening is not at the tip of the penis) during childhood. The goal was to see how they were doing after puberty, checking for complications, urinary symptoms, and sexual function. Resear…

This study looked at different ways to estimate the height of children in the pediatric intensive care unit (PICU). Accurate height is important for calculating nutrition, medicine doses, and other care. Since standard measuring methods are often impossible in the ICU, the study …

This study looked at whether using ultrasound to check children's stomach contents before emergency surgery can help doctors choose a safer way to give anesthesia. The goal is to reduce the risk of stomach contents entering the lungs. 146 children aged 0 to 18 took part, and doct…

This study looked at 136 severely injured patients in the intensive care unit who needed emergency catheters placed in their leg (femoral artery and vein). The goal was to see if using ultrasound to guide the needle reduces complications like bleeding, bruising, or blood clots co…

This study looked at 66 adults to find small molecules called microRNAs in the blood that might explain why some people with osteogenesis imperfecta (brittle bone disease) have a mild form while others have a severe form. Researchers compared people with type 1 (mild) and type 3 …

This study aimed to find out how common low vitamin C levels are in older adults admitted to a hospital unit. Researchers measured vitamin C in the blood of 434 patients over 75 years old to see how many had a deficiency. They also looked at factors like diet, health conditions, …

This study aimed to understand how the healthy brain performs the 'check' process—like verifying information to improve performance. Researchers used brain scans (fMRI and EEG) on 51 healthy volunteers while they performed thinking tasks. The goal was to map which brain areas are…