Hospices Civils De Lyon

This study tested whether adding vasopressin to the standard drug epinephrine helps more people survive a cardiac arrest that happens outside the hospital. Over 2,400 adults were enrolled. The main goal was to see how many patients were alive when they reached the hospital.

This early-phase trial tested whether using mathematical models to schedule chemotherapy drugs docetaxel and epirubicin could reduce severe side effects in 17 patients with metastatic breast cancer. The goal was to find the safest dose and schedule while still giving six cycles o…

This phase 2 trial tested personalized immunotherapy combinations for advanced gastric cancer that had worsened after initial chemotherapy. Researchers matched treatments to tumor genetics: patients with certain genetic features received atezolizumab plus ipatasertib, while other…

This phase 2 trial tests whether a combination of clofarabine and intermediate-dose cytarabine (CLARA) works better than high-dose cytarabine (HDAC) alone as consolidation therapy for younger adults (18-60) with newly diagnosed acute myeloid leukemia (AML). After initial remissio…

This early-phase trial tested a combination of three drugs—olaparib, metformin, and cyclophosphamide—in 35 women with recurrent advanced endometrial cancer that had already been treated with chemotherapy. The goal was to find a safe dose and see if the combination could stop the …

This study tested a drug called GM-CSF in 166 ICU patients who had severe sepsis or septic shock and a weakened immune system. The goal was to see if the drug could reduce the number of new infections acquired in the ICU. Patients received either GM-CSF or a placebo, and research…

This study compared two types of total knee replacements in 160 patients with medial knee arthritis. One group received a fixed-bearing implant, the other a mobile-bearing implant. Researchers measured knee function and X-ray results to see if one design leads to better outcomes.

This study tested whether giving growth hormone to children with short bowel syndrome could help them reduce or stop needing IV nutrition. Fourteen children aged 3-18 who had been on IV nutrition for at least 3 years took part. The results will show if the hormone improves intest…

This study tested whether using a calibrated interdental brush (sized to fit each gap) reduces gum bleeding better than a non-calibrated brush in 51 healthy young adults aged 18-30. Participants used one type of brush daily for three months. The main goal was to compare gum infla…

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…

This study tested a treatment called focused ultrasound (HIFU) that aims to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. It involved 174 men aged 50-80 with intermediate-risk prostate cance…

This study looked at 279 adults with worsening idiopathic pulmonary fibrosis (IPF), a serious lung disease. It compared taking two antifibrotic drugs together (pirfenidone and nintedanib) versus switching to the other single drug. The goal was to see which approach better slows l…

This study tested a new device called Lina Librata that uses a balloon to destroy the lining of the uterus in women with heavy menstrual bleeding. The goal was to see if it works well and causes less pain, so it can be done in an outpatient clinic with local anesthesia. The study…

This study looked at kidney transplant patients who already had one skin cancer. It compared switching their anti-rejection medicine to rapamycin versus staying on standard drugs. The goal was to see if rapamycin could prevent new skin cancers over two years while keeping the tra…

This study tested a synthetic glue called IFABOND to attach surgical mesh during laparoscopic sacrocolpopexy, a surgery for pelvic organ prolapse. The goal was to see if using glue instead of staples or stitches reduces complications like vaginal erosion. 70 women with advanced p…

This study tested a drug called avelumab in 24 women with a rare pregnancy-related cancer (GTN) that did not respond to standard chemotherapy. The goal was to see if the drug could lower tumor markers (hCG) to normal levels and allow treatment to stop. Avelumab works by helping t…

This study tested whether a 6-month home-based walking program could reduce dangerous bleeding inside carotid artery plaque in people with significant blockages but no stroke symptoms. Fifty-six participants either followed an individualized step goal (with coaching) or received …

This study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…

This study compared two types of weight-loss surgery in 256 adults with severe obesity. The goal was to see if a newer, simpler surgery (Omega Loop bypass) works as well as the standard Roux-en-Y gastric bypass, with fewer side effects. Participants were followed for two years to…

This study looked at 120 vulnerable women over 70 with advanced ovarian cancer. It compared three chemotherapy plans: standard two-drug therapy every three weeks, a single drug every three weeks, or a weekly two-drug schedule. The goal was to see which plan allowed patients to co…

This study looked at 141 men with Klinefelter syndrome (47,XXY) to see if younger men (ages 15–22) have a better chance of finding sperm through testicular biopsy compared to older men (ages 23–55). Participants provided two semen samples, and if no sperm were found, they underwe…

This study looked at 78 people with advanced kidney failure who needed a surgery to create an arteriovenous fistula (a connection between an artery and vein) for dialysis. The goal was to see if using a nerve block (axillary block) instead of local anesthesia could reduce early p…

This study tested a treatment for peritoneal carcinosis, a cancer that has spread to the lining of the abdomen from the stomach, bowel, or appendix. The approach combined surgery to remove visible tumors with heated chemotherapy drugs (mitomycin C and irinotecan) pumped directly …

This study tested a special heart-protection method given during heart surgery to see if it could reduce damage to the heart muscle. 210 adults having aortic valve surgery took part. Researchers measured a protein called troponin I in the blood for 72 hours after surgery to check…

This study tested whether giving the immunotherapy drug nivolumab directly into the abdomen is safe after extensive surgery and heated chemotherapy (HIPEC) for advanced ovarian cancer. 22 adults with recurrent ovarian, peritoneal, or fallopian tube cancer took part. The goal was …

This study tested whether placing patients with severe acute respiratory distress syndrome (ARDS) face down (prone) for at least 16 hours a day could lower their risk of dying. 474 adults on ventilators were randomly assigned to prone or standard (semi-recumbent) positioning. The…

This study tested whether a stem cell transplant from a matched donor could improve outcomes for myeloma patients under 65 who had already responded well to their own stem cell transplant. Thirteen patients received a reduced-intensity conditioning regimen followed by the donor t…

This study compared two ways to perform partial knee replacement for osteoarthritis: using a robotic system (Navio) versus traditional manual tools. 66 adults with knee osteoarthritis took part. The goal was to see if robotic assistance leads to better leg alignment and implant p…

This study looked at whether removing the primary rectal tumor before starting chemotherapy helps people with rectal cancer that has spread to other organs (but cannot be cured) live longer. Only 5 people took part, and the trial was completed early. The results are too limited t…

This study tested a drug called bevacizumab in 25 adults with hereditary hemorrhagic telangiectasia (HHT) who had severe liver issues and high heart output. The goal was to see if the drug could improve heart function and reduce the need for a liver transplant, which requires lif…

This study compared two procedures for treating unruptured brain aneurysms: traditional coiling (using tiny coils to block blood flow) and a newer method using a flow diverter stent. 91 adults with specific types of aneurysms took part. The goal was to see which treatment works b…

This study looked at whether a specific heart procedure, done a few minutes after blood flow returns naturally, can limit heart muscle damage in people having a major heart attack. 72 adults with a first heart attack and partially open arteries took part. Researchers measured hea…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This study looked at how safe the drug cabozantinib is for people with advanced liver cancer (hepatocellular carcinoma) who have already tried another treatment called sorafenib. A total of 110 adults took part. The main goal was to see how long patients lived after starting cabo…

This study tested whether a non-invasive arm cuff procedure, called remote ischemic conditioning, could reduce organ failure in 180 adults with septic shock. The cuff was inflated and deflated in cycles to mimic brief blood flow restriction. The goal was to see if this could prot…

This study tested a device that pumps cold, oxygenated fluid through donor livers before transplant. The goal was to see if it reduces early organ damage in livers from older or higher-risk donors. 266 liver transplant patients took part. The approach could help more people get s…

This study tested a method to carefully remove extra fluid from critically ill patients with kidney failure who are on continuous dialysis. The goal was to keep their fluid levels balanced without causing dangerous drops in blood pressure. Researchers used advanced heart monitori…

This study tested whether a 6-day infusion of somatostatin, a drug that lowers pressure in the liver's blood vessels, could prevent ascites (fluid buildup) after liver cancer surgery. 179 patients with liver cancer and underlying liver disease took part. The goal was to see if so…

This study tested a drug called tocilizumab for people with fibrous dysplasia of bone who still had pain after standard treatment. The drug blocks a protein linked to bone breakdown. Nineteen adults participated in this small, early-stage trial to see if the drug could reduce bon…

This study compared two treatments for early-stage esophageal cancer in people with Barrett's esophagus: a new, less invasive procedure using radiofrequency ablation (a balloon that burns away abnormal cells) versus standard surgery to remove part of the esophagus. The goal was t…

This study tested whether a program of regular geriatric checkups, nutrition support, and weekly Tai Chi classes could help women over 70 with breast cancer stay on their hormone therapy. The 12 participants had their blood tested over 3 years to see if they were taking their med…

This study tested whether adding a second drug (pegylated interferon) to the standard leukemia medication nilotinib helps people with newly diagnosed chronic myeloid leukemia (CML) achieve a deeper molecular response faster. About 200 adults under 65 with early-stage CML took par…

This study tested whether minoxidil, a blood pressure medicine, can improve blood vessel health in children with Williams-Beuren syndrome. The condition causes weak blood vessels due to a missing gene. 21 children took minoxidil or a placebo for 12 months, and researchers measure…

This study tested whether a routine biopsy three months after kidney transplantation can help doctors adjust immunosuppressive drugs to prevent graft loss and reduce side effects. 346 patients were split into two groups: those with mild inflammation received extra steroids, while…

This study tested whether adding a special pressure wire measurement (FFR) to standard angiography helps doctors decide the best treatment for people with multiple blocked heart arteries. Over 900 patients were randomly assigned to get either angiography alone or angiography plus…

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This study tested whether eating fortified biscuits and cookies daily for nine weeks could lower inflammation in 62 adults with abdominal obesity and cardiometabolic risk. Participants ate either fortified or standard biscuits and cookies, and researchers measured inflammatory ma…

This study tested whether methotrexate, an older drug used for arthritis, works as well as cyclosporine for people with moderate to severe atopic dermatitis (eczema). One hundred adults received either drug for 24 weeks. The main goal was to see if eczema severity dropped by half…

This study tested whether a dye called 5-ALA, which makes tumor cells glow during surgery, helps surgeons remove more of a deadly brain cancer called glioblastoma. 170 adults with newly diagnosed glioblastoma were randomly assigned to receive either 5-ALA or a placebo before surg…

This study tested a temporary urethral stent in 9 men with spinal cord injuries who had trouble emptying their bladders. The stent is placed under local anesthesia to keep the urinary channel open. The goal was to see if patients felt their voiding improved, and to check for prob…

This study compares two machines that clean the blood of toxins when the liver fails: MARS (a standard system) and SPAD (a simpler, cheaper alternative). Thirty-four patients with severe liver failure will try both machines in random order. The goal is to see if SPAD works as wel…

This pilot study tested hand and forearm transplants in 7 people who lost both hands. The goal was to see if the brain can adapt to the new hands and improve daily life. Participants had to be between 20 and 40 years old and have had their amputation 3 months to 3 years before th…

This phase 2 study tested the drug olaparib in 35 people with recurrent IDH-mutant high-grade gliomas, a type of brain tumor. The goal was to see if olaparib could stop the tumor from growing for at least 6 months. Participants took olaparib tablets twice daily until their diseas…

This study tested a new way to place dental implants in the upper jaw without a sinus lift. 60 adults missing teeth took part. One group got implants using image-guided surgery, the other had a standard sinus lift with bone graft. The goal was to see if the new method works as we…

This study compared two types of weight-loss surgery: the newer SADI-S and the standard RYGB. Researchers wanted to see which one leads to more weight loss after two years. The trial involved 382 adults with severe obesity and measured safety and nutritional effects as well.

This study tested whether giving intravenous immunoglobulin (IVIG) to children with toxic shock syndrome is practical and might help. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The trial enrolled 30 children in intensive care, giving them either IVIG…

This study tested a device called MitraClip, which is a small clip placed through a tube in a vein to repair a leaky mitral valve in the heart. The trial included 304 people with severe mitral regurgitation and heart failure. Half got the clip plus standard medical care, and half…

This study tested whether a single injection of cyclosporine, given right before opening a blocked artery, could improve outcomes for people having a major heart attack. About 970 patients received either cyclosporine or a placebo. Researchers tracked deaths, hospitalizations for…

This study tested whether applying estrogen cream to the penis for two months before surgery reduces complications in boys with severe hypospadias, a birth defect where the urethra opening is not at the tip. 244 boys aged 9-36 months received either estrogen cream or a placebo cr…

This early-phase study tested stereotactic radiotherapy, a precise type of radiation, on 13 people with small kidney cancers (≤4 cm). The goal was to find the highest safe dose by gradually increasing the radiation in four steps. Participants were followed for up to 5 years to mo…

This study tested whether the usual vitamin D doses given to children with chronic kidney disease, kidney transplants, or nephrotic syndrome are enough to raise their vitamin D levels to a healthy range. Forty-three children received vitamin D vials based on their weight and star…

This study tested a special nursing strategy to prevent pressure sores in patients with severe lung problems who need to lie face down (prone position). The trial included 160 adults in intensive care who were on breathing machines. The strategy involved protecting the eyes, tilt…

This study tested whether adding the drug bevacizumab (Avastin) to standard chemotherapy (Folfiri) helps people with advanced, aggressive neuroendocrine carcinoma live longer after their first treatment stops working. The trial included 153 adults with inoperable cancer that star…

This study tested whether filtering the blood (therapeutic plasma exchange) could help severe COVID-19 patients by removing harmful immune molecules that cause lung damage. Twenty-one adults in intensive care with COVID-19 and lung failure were randomly assigned to receive either…

This study tested whether using a special bag during laparoscopic fibroid removal (myomectomy or hysterectomy) can prevent the spread of cells that might be cancerous. Forty-eight women were randomly assigned to have the procedure with or without the bag. Researchers then checked…

This study tested two different chemotherapy regimens (R-CHOP14 and R-ACVBP14), both combined with the drug rituximab, in 222 adults aged 18 to 59 with an aggressive type of B-cell lymphoma. The goal was to see which combination led to a complete response after four cycles of tre…

This study tested whether a special MRI scan called T1 mapping can detect kidney damage in people with Fabry disease, a rare genetic disorder. Researchers compared MRI results from 70 adults with and without Fabry disease. The goal was to see if this non-invasive scan could help …

This study measures oxygen pressure in the skin of the upper arm to help diagnose chronic limb ischemia, a condition where blood flow is severely reduced. Researchers will test 30 healthy volunteers and at least 30 patients with known arm artery disease to find normal values and …

This study tested whether a fast removal of 250 ml of fluid during dialysis can predict which ICU patients with acute kidney injury are at risk of unstable blood pressure. Twenty adults on mechanical ventilation and continuous dialysis underwent two different speeds of fluid remo…

This study compared two ways to biopsy the prostate in 275 men with suspected cancer. The standard method takes random samples from the gland, which can miss aggressive tumors or find harmless ones. The new method uses MRI images to guide the needle to suspicious spots. The goal …

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This early study tested a special light probe that helps surgeons see brain tumor tissue during an operation. Eleven adults with suspected brain tumors took part. The probe uses a drug that makes tumor cells glow, and the goal was to see if the device could accurately tell tumor …

This study tested whether a cone-beam CT scanner (often used for dental imaging) can detect cartilage damage in the wrist, ankle, elbow, and knee as well as a standard multidetector CT scanner. 69 adults who needed an arthroscan (a joint X-ray with dye) received both scans in ran…

This study tested whether adding a dynamic knee laxity measurement to standard MRI can improve diagnosis of partial anterior cruciate ligament (ACL) tears. Researchers enrolled 151 people with knee injuries and compared the new method to standard MRI. The goal was to see if the c…

This study looked at whether a combination of 7 biomarkers in the blood can more accurately diagnose severe bacterial infections in children aged 7 days to 36 months with fever. Researchers enrolled 983 children and compared the biomarker panel's performance against standard test…

This study tested whether a newer, high-resolution swallowing test (high-resolution manometry) is better than the standard test (conventional manometry) at diagnosing the cause of swallowing problems in 247 adults with unexplained dysphagia. Participants underwent both tests to s…

This study tested a new device called the BRUXENSE occlusal splint to see if it can help diagnose sleep bruxism (teeth grinding). Seven adults with bruxism tried wearing the splint for 10 nights. The goal was to see if they could use it comfortably and if it collected enough data…

This study tested whether a special scan called [11C]-Methionine PET/MRI can better locate tiny pituitary tumors that cause Cushing's disease. Standard MRI often misses these tumors, leading to risky exploratory surgery. The study involved 33 adults with confirmed Cushing's disea…

This study tested whether a device called MAIA, which measures light sensitivity in the retina, can predict when intermediate age-related macular degeneration (AMD) progresses to the advanced stage. Researchers followed 182 people who already had advanced AMD in one eye and inter…

This study tested a special microscope called Cellvizio that lets doctors see inside the fallopian tubes in real time during surgery. The goal was to find early precancerous lesions that might lead to ovarian cancer. Forty women having their fallopian tubes removed for various re…

This study tested whether an ultra-low dose chest CT scan can find lung blood vessel malformations in people with hereditary hemorrhagic telangiectasia (HHT) as well as the standard low-dose CT scan, but with much less radiation. 45 HHT patients received both scans, and radiologi…

This study tested whether a quick, non-invasive ultrasound of the stomach can accurately detect if a child has too much fluid in their stomach before anesthesia. 92 healthy children aged 1-10 drank a set amount of clear liquid, then had a 3-minute ultrasound. The goal was to see …

This study tested whether measuring a substance called BD glucan in the abdominal fluid of ICU patients with peritonitis can diagnose fungal infections faster than standard lab cultures. Fungal peritonitis is deadly, and current tests take at least 48 hours. The study enrolled 12…

This study tested a special PET/MR scan using a radioactive tracer called 18F-sodium fluoride to see if it can better identify dangerous carotid artery plaques. The researchers compared 6 patients who recently had a stroke with 6 who had no symptoms, all with significant plaque b…

This study tested whether a cone-beam CT scanner (Newtom 5G) can detect and classify fractures of the arms and legs as accurately as a standard CT scan. 43 adults with suspected fractures received both scans. Researchers compared how well each scan identified the type of fracture…

This study tested a new device called DiCART that automatically measures capillary refill time — how quickly skin color returns after pressing it. Doctors use this to check blood flow in shock patients, but current manual methods vary a lot. The study involved 20 healthy adults w…

This study tested whether a combination of 11 blood markers can more accurately diagnose late-onset sepsis in newborns in the NICU. Current methods are slow and often lead to unnecessary antibiotic use. Researchers enrolled 233 newborns with signs of infection to see if this biom…

This study tested whether an ultrasound of the optic nerve sheath (the lining around the nerve connecting the eye to the brain) can accurately detect dangerously high pressure inside the skull in children. Researchers measured the nerve sheath diameter in 230 children with brain …

This study tested whether two imaging methods—Histoscanning and multiparametric MRI—can accurately detect and locate prostate cancer that comes back after radiation therapy. Thirty men with rising PSA levels or biopsy-confirmed recurrence were enrolled. Each participant received …

This study tested whether prazosin, a drug normally used for high blood pressure, could prevent post-traumatic stress disorder (PTSD) in people who recently experienced a traumatic event like an accident or assault. Researchers gave the drug to 15 adults who showed signs of acute…

This study looked at 86 women with Factor V Leiden or Factor II mutations who had no history of blood clots. Researchers compared how long doctors prescribed blood thinners after childbirth (less than 2 weeks vs. 6 weeks) to see if shorter treatment was still effective at prevent…

This study tested a program to help women over 50 who had a wrist or arm fracture get proper follow-up care for osteoporosis. The program included oral advice, a leaflet, and phone reminders to see their doctor and get a bone density test. 436 women took part, and the study compa…

This study tested a care program for people over 70 who were starting to have trouble moving around. The program included personalized exercise coaching and nutrition advice from a doctor and a fitness specialist. The goal was to see if this approach could prevent further loss of…

This study tested whether a combination of education and exercise could help healthcare workers avoid repeat episodes of lower back pain. Over 350 workers with a history of back pain took part in small-group sessions or continued usual care. The goal was to see if the program red…

This study tested whether giving the seizure drug levetiracetam right away can prevent seizures in people who had a brain bleed (hemorrhagic stroke). About 50 adults with a recent brain bleed received either the drug or a placebo. The goal was to see if the drug could reduce seiz…

This study tested a special program to prevent falls in elderly patients staying in hospital. The program included identifying who is at risk, taking steps to prevent falls (like exercise and safety checks), and teaching patients how to get up safely after a fall. Over 1,800 pati…

This study tested whether placing infants under 6 months with moderate to severe bronchiolitis on their stomachs (prone position) while on high-flow oxygen could reduce the need for more intensive breathing support. A total of 452 infants in critical care were randomly assigned t…

This study tested a 5-month mindfulness meditation program for hospital staff to see if it improves mental well-being and work fulfillment. 108 professionals from 8 departments took part, with some receiving the program and others serving as a control group. The goal was to see i…

This study looked at whether using a virtual reality hypnosis headset during a frozen embryo transfer is practical and can help lower anxiety. Fifty women undergoing IVF used the headset during the procedure. The main goal was to see if the headset could be used without technical…

This study tested whether doing handgrip exercises before and after surgery can improve the size and function of dialysis fistulas in people with advanced kidney disease. 40 patients participated, and the main goal was to see if the fistula diameter increased. The approach is sim…

This study looked at whether a surgery called anterior sacrospinofixation, which uses a woman's own tissue instead of synthetic mesh, can improve symptoms of pelvic organ prolapse. 66 women with moderate to severe prolapse were followed for 2 months after surgery. The main goal w…

This study tested whether a short educational session before outpatient orthopedic surgery helps patients manage their pain better at home. Over 400 adults took part, with some receiving the extra teaching and others getting usual care. The goal was to see if the education led to…

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can help people with chronic, severe tinnitus (ringing in the ears). Sixty-four adults received either real or fake rTMS at different intensities. The goal was to see if the treatment reduces tinnitus l…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who survived severe COVID-19 recover more quickly. Twenty-two patients who had been on ventilators in the ICU took part in a 4-week rehab program. Half did cycling with FES,…

This study tested whether a non-invasive brain stimulation technique called tDCS can help people with schizophrenia whose symptoms persist despite medication. 141 adults received either real or sham tDCS over 10 sessions. The goal was to see if active stimulation leads to a meani…

This study tested whether regular nurse counseling could help teenagers with type 1 diabetes feel more in control of their condition and improve their blood sugar levels. 77 teens aged 13-18 with poorly controlled diabetes took part. One group received routine care, while the oth…

This study tested whether a custom compression vest (SED CICATREX®) can reduce shoulder pain and improve stability in adults with hypermobile Ehlers-Danlos syndrome. 48 participants wore the vest for 4 weeks, then went without it for 4 weeks. Researchers measured muscle strength,…

This study tested whether injecting botulinum toxin (like Botox) into the lower esophagus can ease symptoms of nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either the toxin or a placebo in a double-blind setup. The m…

This study tested a non-invasive brain stimulation method called tDCS to see if it can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 healthy volunteers and patients with long-term nerve pain. The goal was to measure changes in pain levels and…

This study tested whether cycling for 30 minutes during each dialysis session, three times a week for three months, could improve blood flow in the legs of people on chronic hemodialysis. The goal was to see if this simple exercise could help prevent serious complications like wo…

This study compared using an electronic tablet with age-appropriate games versus the sedative midazolam to reduce anxiety in children before outpatient surgery. 118 children aged 4 to 10 were randomly assigned to either play on a tablet or take midazolam. Researchers measured anx…

This study looked at two treatments for Osgood-Schlatter disease, a common cause of knee pain in growing teens who play sports. One group wore a leg cast for 4 weeks followed by physical therapy, while the other group stopped all sports for 8 weeks and did physical therapy. The g…

This study looked at how well a gel called Bulkamid works for stress urinary incontinence in women. The gel is injected around the urethra to help the bladder control urine flow. Researchers tracked symptom improvement in 70 women who received the injection. The goal was to see h…

This study tested two types of arm exercises in 26 people who had a stroke and had trouble using one arm. One type used automatic movements (where the target moves to guide the arm), and the other used intentional movements (where the target stays still). The goal was to see whic…

This study looked at whether foot reflexology—a type of foot massage—can reduce nausea and vomiting caused by platinum-based chemotherapy. Eighty people with lung or digestive cancer received reflexology sessions during their chemo infusions and were asked to do self-massage betw…

This study tested whether hearing aids can improve thinking, daily behavior, and quality of life in people with mild to moderate Alzheimer's disease who also have age-related hearing loss. Fifty-one participants were split into two groups: one got real hearing aids for 12 months,…

This study tested two different drug combinations given through a small tube near the spine to control pain after video-assisted lung surgery. 90 adults participated to see if adding sufentanil to ropivacaine reduces the need for morphine and improves pain scores compared to ropi…

This study tested a drug called pasireotide in 57 adults with high-output enterostomies (a surgically created opening in the belly) whose fluid loss was not controlled by standard treatments. The goal was to see if the drug could reduce the amount of fluid lost through the stoma …

This study looked at whether injecting botulinum toxin into two leg muscles (rectus femoris and semitendinosus) can improve walking and reduce stiffness in children with cerebral palsy. 23 children aged 7 to 17 who could walk (with or without aids) took part. Researchers measured…

This study looked at the safety of giving lidocaine through a vein during weight-loss surgery. Fifty adults having laparoscopic bariatric surgery received lidocaine, and their blood levels were measured at several points. The goal was to confirm that using a dose based on adjuste…

This study tested a program to help older cancer patients get stronger before and after surgery. 148 patients aged 70+ (or 60+ with other health issues) took part. The program included exercise, nutrition advice, and education to reduce complications and improve recovery.

This study tested whether trained mothers who breastfed their own preterm babies could help other mothers of preterm infants breastfeed longer. Over 1,700 mother-infant pairs in European NICUs received either usual care or additional peer counseling during hospitalization and up …

This study tested the Cavaterm™ system, a balloon device that removes the lining of the womb, to treat heavy menstrual bleeding in women who did not get better with medication. 20 women were treated and followed for 2 months to see if their bleeding improved. The goal was to ease…

This study compared two ways to manage pain after knee replacement surgery: a nerve block in the thigh (adductor channel block) versus injecting numbing medicine around the knee joint. 98 adults having their first knee replacement took part. The goal was to see which method reduc…

This study tested whether giving the numbing drug lidocaine through a vein during and after ear, nose, and throat cancer surgery could lower the need for strong opioid painkillers and reduce long-term pain. 143 adults having major head and neck cancer surgery were randomly assign…

This study tested different doses of melatonin to see which one best improves sleep quality in autistic children aged 3 to 12 who have trouble sleeping. Researchers measured things like how long it takes to fall asleep, total sleep time, and number of night awakenings using sleep…

This study tested a computer-based training for people who lost part of their vision after a stroke or brain injury. The training used a moving target to help patients automatically look into their blind area. 22 adults with hemianopia (blindness in half the visual field) complet…

This study looked at 27 children aged 6 to 11 with cystic fibrosis who were starting treatment with CFTR modulators (Kaftrio). The goal was to see if the drug improves nose and sinus symptoms and quality of life after one year. Researchers used a special questionnaire called SN-5…

This study tested whether a simple ear acupuncture treatment could reduce anxiety in women about to have a planned cesarean section. 91 women were split into three groups: one got real acupuncture needles on the ear, another got a needle-free patch (placebo), and a third got no t…

This study looked at whether early, regular visits from a palliative care team can improve quality of life for adults with acute leukemia that has returned. 49 patients were assigned to either receive this extra support or standard care. The team addressed physical, emotional, an…

This study looked at whether a supervised, adapted exercise program can improve fitness and quality of life in children aged 6 to 18 with osteogenesis imperfecta, a rare genetic condition causing fragile bones. Thirty participants did 30-minute exercise sessions twice a week for …

This small pilot study tested a device that gently stimulates the vagus nerve through the skin in women with irritable bowel syndrome (IBS). Over six months, researchers measured changes in digestion, inflammation, symptoms, and quality of life. The goal was to see if this non-in…

This study tested whether showing people a live ultrasound image of their tongue during speech therapy helps them improve faster. It included 18 adults and children with speech problems after surgery or brain injury. They compared therapy sessions with and without the ultrasound …

This study tested a new virtual reality rehab program for adults with two cochlear implants who struggle to locate where sounds come from. Twelve participants completed 8 sessions over a month, using head movements and joystick feedback to practice sound localization. The goal wa…

This study tested different doses of the drug ephedrine to find the most effective one for treating low blood pressure that occurs during surgery in newborns and infants up to 6 months old. The trial involved 120 infants who developed low blood pressure while under anesthesia. Re…

This pilot study tested whether clonidine, a drug used for high blood pressure, can reduce impulse control disorders (like gambling or overeating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The study measured changes in…

This study tested whether gabapentin and memantine can reduce the speed, size, and frequency of involuntary eye movements (nystagmus) in people with oculopalatal tremor, a condition caused by brainstem damage. Seven adults took each drug separately, and researchers measured eye m…

This study tested two drugs, gabapentin and memantine, in 10 people with multiple sclerosis who have a constant eye shaking called pendular nystagmus. The goal was to see if either drug could reduce the eye movement and improve vision and quality of life. Each person tried both d…

This study worked with patients and healthcare professionals to design a program that helps older adults safely stop taking medications that can cause confusion, falls, and other harms. The team held focus groups and workshops to understand barriers and create a step-by-step plan…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study collected tissue and blood samples from 143 people with malignant pleural effusion (cancer that has spread to the lining of the chest). The goal was to create a biobank for future research into why cancer cells in the chest may differ from the original tumor. No treatm…

This study tested a special MRI technique called T1rho to measure hip cartilage in 31 healthy volunteers. The goal was to see if the method gives consistent results and to establish normal values. This could help doctors detect early signs of hip osteoarthritis, a common and pain…

This completed study looked at how 26 premature infants and babies with Pierre Robin sequence suck. The goal was to better understand their feeding challenges so doctors and families can offer better support. Researchers used a special device to measure sucking patterns, aiming t…

This completed study looked at sleep problems in over 1,100 children and adults with specific learning disabilities (like dyslexia or dyspraxia), with or without ADHD. Participants filled out online questionnaires about their sleep habits. The goal was to find out how common diff…

This study checks if bedside ultrasound can accurately measure thigh muscle size in critically ill children, compared to the gold-standard MRI. Researchers will scan 35 sedated children in the ICU with both methods to see if ultrasound is reliable enough for daily use. If it work…

This study looked at 100 healthy adults to see how tobacco and alcohol use cause genetic changes in cells lining the mouth. Researchers collected cheek cells using a gentle brush and searched for mutations linked to oral cancer. The goal was to understand how these substances mig…

This study looks at people who carry one copy of a mutated AGXT gene, which is linked to a rare kidney stone disease. Some carriers develop kidney stones, while others do not. Researchers will compare their urine oxalate levels and lifestyle factors to find out what triggers symp…

This study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…

This study looked at whether children with dyscalculia (a math learning disability) have trouble automating counting procedures rather than recalling math facts. Three children aged 8–11 solved simple addition problems over three years while researchers measured their response ti…

This study looked at whether a protein called IRAP, found in the blood, can be used as a marker for insulin sensitivity (how well the body uses insulin). Researchers measured IRAP levels in 21 healthy adults during a special test called a hyperinsulinemic-euglycemic clamp, which …

This study looked back at 50 adults who had jaw surgery to fix an anterior open bite (a gap between upper and lower front teeth). Researchers wanted to see if tongue position and speech or physical therapy after surgery affected whether the gap came back. The goal is to find bett…

This study looked at whether drinking calvados (a strong apple brandy) during a high-calorie festive meal helps digestion, as some people believe. Eight healthy volunteers ate a standardized 1850-calorie meal and either drank calvados with sorbet or water with sorbet. Researchers…

This study tested whether telephone interviews after a stroke can help patients better understand and follow their medication plans. 54 adults who had an ischemic stroke and were returning home received a pharmaceutical interview before discharge, followed by phone calls at one w…

This study looked at how chemotherapy affects taste and smell in 69 people with digestive cancers. Researchers used questionnaires to track changes in food preferences and eating habits before, during, and after the first round of chemo. The goal was to understand how these senso…

This study looked at 74 healthy adults aged 20 to 80 to understand how natural aging affects heart muscle scarring (fibrosis) and heart function. Participants had MRI scans, blood tests, and skin measurements to detect fibrosis. The goal was to learn how aging alone changes the h…

This study tested whether measuring the area of skin sensitivity around a heart surgery scar can predict if a patient will have chronic pain 3 months later. Researchers used a pain mapping technique on 84 patients two days after surgery. The goal is to find a way to identify high…

This completed study looked at whether circulating tumor cells (CTCs) in the blood can help predict or detect early return of oropharyngeal cancer. Researchers took blood samples from 12 patients at different times (diagnosis, after treatment, and during follow-up) and analyzed t…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies in their blood over two years. Researchers wanted to see if CF patients get infected less often or have milder symptoms. About 331 children and adults with CF from Europe gave blood samples and…

This study looked at whether adding einkorn, an ancient cereal, to the diet could change the types of bacteria in the mouth. Researchers focused on bacteria linked to gum disease and cancer risk. Thirty-one healthy adults ate einkorn and had their oral bacteria measured over time…

This completed study looked at 50 non-diabetic people with chronic kidney disease to see if the drug dapagliflozin changes the types of bacteria in their gut. Researchers measured gut bacteria diversity and related waste products in the blood before and after 12 weeks of treatmen…

This study followed 10 males who had surgery for hypospadias (a birth defect where the urine opening is on the underside of the penis) to see how they fared long after puberty. Researchers performed physical exams, bladder and testicle ultrasounds, and blood tests to check for co…

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used safe brain scans, EEG, and eye-tracking tests at three ages. The goal was to understand normal development and how early experiences shape the brain. This…

This study aimed to better understand why some people develop delayed brain damage after a brain aneurysm rupture. Researchers measured platelet activation over time in 90 patients, comparing those with aneurysm bleeds to those with other types of brain bleeds. The goal was to cl…

This study looked at how the immune system changes in elderly people over 75 who have multiple chronic health problems. Researchers measured a specific immune marker (mHLA-DR) from a simple blood sample to understand the combined effects of aging and chronic diseases. The goal wa…

This completed study collected extra blood samples from 28 adults with thyroid disorders to help standardize thyroid-stimulating hormone (TSH) tests. Different labs often use different tests, making it hard to compare results. By analyzing these samples, researchers hope to make …

This study looked at 5 people with a torn aorta (aortic dissection) who needed a stent to fix it. Researchers used special MRI scans before and after surgery to measure blood flow changes in the aorta. The goal was to see if MRI can help doctors understand how well the treatment …

This study followed 76 women with congenital toxoplasmosis (a parasitic infection present from birth) to see if pregnancy increases the risk of eye inflammation (retinochoroiditis). Researchers checked eye exams done during pregnancy and after childbirth, comparing them to non-pr…

This study followed 385 adults who came to the emergency department with shortness of breath. Doctors used lung ultrasound at the bedside to help diagnose the cause. The goal was to see if this simple, non-invasive test could lower the number of deaths and repeat hospital visits …

This study looked at whether continuous kidney replacement therapy can cause temporary heart muscle weakness (myocardial stunning) in critically ill patients with severe acute kidney injury. Researchers used echocardiograms to measure changes in heart wall motion in 42 adults. Th…

This study looked at 100 pregnant women to determine normal ranges for a blood test called dRVVT, which checks for clotting problems. The goal is to better identify antiphospholipid syndrome, a condition that raises the risk of blood clots and pregnancy complications. By establis…

This study looked at how healthy adults' brains handle the decision to double-check their work. Using brain scans (fMRI and EEG), researchers aimed to pinpoint which brain areas are active during checking tasks. The goal is to better understand compulsive checking in conditions l…

This study looked at 20 adults who had NMDA receptor encephalitis, a rare brain condition that can cause psychosis, memory loss, and seizures. Researchers used questionnaires to measure thinking skills, mood, fatigue, and quality of life after the acute phase. The goal was to und…

This study examined tissue samples from 50 patients with staphylococcal bone and joint infections to see if bacteria can hide inside human cells. Researchers used special staining to detect intracellular staphylococci and identify which cell types they occupy. The goal was to bet…

This study looked at why people with sickle cell disease often get hard-to-heal leg ulcers. Researchers measured blood flow, nerve function, and blood markers in 70 patients with and without ulcers. The goal was to better understand what causes these wounds, not to test a new tre…

This study looked at whether placing infants with severe bronchiolitis on their stomach (prone) while on breathing support reduces their work of breathing. Sixteen babies under 6 months old were randomly assigned to start either on their back or stomach, then switched after an ho…

This study looked at whether a technique called postconditioning, done during angioplasty to reopen blocked heart arteries, can reduce damage to the heart muscle. 44 adults having their first heart attack took part. The researchers used MRI scans to measure the area of blocked sm…

This study looked at 154 elderly patients (70 years or older) having hip fracture surgery. It compared a special type of spinal anesthesia (low-dose hypobaric lateral spinal anesthesia) with general anesthesia to see which one keeps blood pressure more stable during surgery. The …

This study looked at whether a non-invasive eye scan (OCTA) can predict how well blood flows in the heart's small arteries. Researchers examined 101 people with coronary artery disease, comparing eye images to measurements taken during heart catheterization. The goal was to see i…

This study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…

This completed study collected MRI and 3D ultrasound images from 2 men with prostate cancer who had their prostate removed. The goal was to create a database that could later be used to train a computer system to detect cancer without needing a biopsy. This is a very early step i…

This study looks at whether a protein called periostin is higher in the blood of people with fibrous dysplasia, a rare bone disease that can cause pain and fractures. Researchers will take blood samples from 65 patients and compare periostin levels to how many bones are affected …

This study looked at 82 adults getting a liver transplant to see if using a special blood test called ROTEM helps doctors manage bleeding better than standard tests. The goal was to see if ROTEM could reduce the amount of blood products given during surgery. Researchers tracked c…

This study tested whether an automated closed-loop system could better manage fluid levels during major abdominal surgery compared to standard care by an anesthesiologist. Forty-six high-risk patients were randomly assigned to receive fluids via the automated system or manual con…

This study looked at how children aged 8 to 17 with two cochlear implants locate sounds in three-dimensional space. Using virtual reality and motion tracking, researchers measured pointing accuracy and head movements during sound tasks. The goal was to better understand spatial h…

This study looked at genetic and immune system differences in children with lupus, a chronic autoimmune disease. Researchers collected blood samples from 271 participants to search for mutations in known lupus genes and discover new ones. The goal is to better understand what cau…

This study looks at how common muscle loss (sarcopenia) is in people with spondylarthropathy, a type of inflammatory arthritis. Researchers will measure muscle strength, walking speed, and body composition in 106 adults. The goal is to better understand and detect this disabling …

This study examined 98 children with a symptomatic discoid lateral meniscus (DLM), a condition where the knee's cartilage is shaped abnormally. Researchers looked for a link between a child's inability to fully bend one knee and a dislocation of the meniscus seen during surgery. …

This study looked at how gut bacteria in people with chronic kidney disease (CKD) produce harmful toxins that build up in the body. Researchers collected stool samples from 20 patients with advanced CKD and placed them into an artificial intestine to test whether probiotics could…

This study looked at brain activity in 108 women to see if overeating shares features with addiction. Researchers measured brain waves (P300) while women listened to sounds, and also asked about eating habits and mood. The goal was to compare obese women with eating disorders to …

This study looks at how pancreas-kidney transplantation changes bile acids and gut-related metabolism in people with type 1 diabetes and kidney disease. Researchers will measure bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transp…

This study looked at 139 adults with high blood pressure to find out why some blood pressure medicines work better for certain people. Researchers checked things like diet, body size, and genetics to see how they affect drug response. The goal was to learn more about high blood p…

This study looked at whether a special hospital team and computer alerts could help doctors and nurses follow best practices for caring for malnourished children. Over 1,400 children and hospital staff took part. The goal was to see if better adherence to guidelines would lead to…

This study looked at 65 people with cystinosis to see how well they take their cysteamine medicine and how that relates to brain problems. Researchers measured medicine use with special bottle caps and diaries, and checked for cystine buildup in the brain using scans and spinal t…

This study looked at how the brain processes sound in 43 deaf adults who have two cochlear implants. Researchers compared their brain activity to people with normal hearing using PET or EEG scans. The goal was to understand if the timing between activating the two implants affect…

This study looked at how well the ReVive™ SE device works to restore blood flow in the brain during a stroke. Only one patient took part, and the goal was to see if the device is useful in standard care. The main measure was how much blood flow returned after using the device.

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This study tested a transitional care program for patients aged 75 and older leaving the hospital. A nurse created a care plan, contacted their primary doctor, and arranged a follow-up visit. The goal was to see if this reduces unplanned hospital readmissions or emergency visits …

This study looked at whether using ultrasound to check what's in a child's stomach before emergency surgery can help doctors choose a safer way to give anesthesia. 146 children took part. The goal was to see if the ultrasound results led doctors to change their usual approach, po…

This study looked at 267 women with early-stage cervical cancer to compare two surgical approaches: removing all pelvic lymph nodes versus removing only the sentinel (first) lymph node. The goal was to see which method causes fewer complications within 6 months after surgery. Res…

This study looks at genetic differences in children with alpha-1 antitrypsin deficiency, a rare inherited condition that can cause liver disease. Researchers will compare gene patterns between children who develop liver problems and those who do not, using blood samples from abou…

This study looked at how sickle cell disease affects leg muscles. Researchers compared muscle strength and fatigue in 77 people with and without sickle cell disease during a short exercise. The goal was to learn if muscle problems contribute to poor physical fitness in sickle cel…

This study aimed to find factors that can predict whether someone will develop post-traumatic stress disorder (PTSD) after a traumatic event like a serious injury or violence. Researchers followed 460 adults who came to the emergency room within a month of trauma and were at mode…

This study looked at 49 adult cochlear implant users to see if electrical measurements from the inner ear can predict the best sound levels for each person. Researchers collected data during surgery and after months of implant use, then compared it to standard hearing tests. The …

This study looked at how the brain processes speech sounds in 25 people with language impairment or hearing loss. Researchers used e-learning games or hearing aids to see if these interventions change brain activity. The goal was to better understand the underlying problems and g…

This study looked at cells from 21 people with BPAN, a rare brain disease caused by a gene mutation. Researchers wanted to see if the cells have trouble handling stress, which might explain why brain cells die. No treatment was given; the goal was simply to learn more about the d…

This study is developing a clinical score to predict vitamin D deficiency without a blood test. Over 2,500 adults will fill out a questionnaire about sun exposure and diet, then have their vitamin D levels measured. The goal is to create a tool that helps doctors decide who truly…

This study used PET scans to examine brain changes in people with Parkinson's disease at different stages. Researchers looked at two brain chemical systems—dopamine and serotonin—to understand non-motor symptoms like mood and thinking problems. 49 participants, including healthy …

This study looked at how the immune system responds to Clostridium difficile infection in hospitalized patients. Researchers took blood samples every two days to measure immune markers. The goal was to find out why some patients have repeat infections. The study involved 56 parti…

This study collected and stored blood and tissue samples from over 2,100 people with digestive peritoneal carcinomatosis, a type of cancer that spreads in the abdomen. The goal was to create a large, high-quality biobank for future research into better ways to predict, diagnose, …

This completed study followed 255 women with gestational diabetes to see if simple blood tests during pregnancy could predict who will develop type 2 diabetes after giving birth. Researchers measured three markers (CRP, MDA, and adiponectin) and checked glucose tolerance three mo…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their heart function related to their kidney problem. The goal was to impr…

This completed pilot study looked at 47 adults with hereditary hemorrhagic telangiectasia (HHT) who also have liver involvement. Researchers used exercise echocardiography (heart ultrasound while pedaling) to measure lung artery pressure during exercise. The goal was to see if th…

This study tested two ways of helping critically ill patients who are having trouble coming off a breathing machine (ventilator). One method used a T-piece (a simple tube), while the other used a machine that gives extra pressure support. The goal was to see which approach helps …

This study tracked 289 healthcare workers in short-stay hospital wards to see how often they caught the flu, both with and without symptoms. Participants gave blood samples and nasal swabs to confirm infections. The goal is to understand how many silent flu cases occur among staf…

This study looked at how much people who had a transient ischemic attack (TIA or mini-stroke) understand about their condition after being treated in the emergency room. About 100 adults in Lyon, France, answered a questionnaire to test their knowledge of symptoms, risk factors, …

This completed study enrolled over 1,000 people with drug-resistant partial epilepsy to see if severe drops in oxygen levels during seizures can predict later sudden unexpected death (SUDEP). Participants had their seizures recorded with video-EEG monitoring. The goal is to bette…

This study followed 88 adults with moderate to severe traumatic brain injury for up to 18 months. Researchers used MRI scans and hormone tests to see if hormone deficiencies after injury are linked to lower quality of life. The goal was to better understand these connections, not…

This completed study looked at how the immune system is weakened after septic shock, severe trauma, burns, or major surgery. Researchers took blood samples from 552 patients and healthy volunteers to measure immune function. The goal was to find better ways to predict and manage …

This study used a special MRI technique to measure phosphate and ATP (energy) levels inside muscle cells of 11 kidney dialysis patients during a 4-hour session. The goal was to find out whether phosphate removed during dialysis comes from inside cells. If it does, it might explai…

This study tests three different forms of DHA (an omega-3 fat) to see which one gets into the body and brain most effectively. Four healthy men aged 60–70 took a single dose of each form, with a four-month break in between. Researchers measured DHA levels in blood cells and plasm…

This study looked at 24 children (ages 6-17) with narcolepsy or hypersomnia to see if changes in their metabolism explain why they often gain weight and become obese. Researchers measured energy use at home and in the hospital using activity trackers. The goal was to understand t…

This study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…

This study looked at 1,000 people aged 40-80 with type 2 diabetes or obesity to find the best way to screen for advanced liver scarring (fibrosis) from fatty liver disease. Researchers tested combinations of blood tests and a special ultrasound (FibroScan) to see which approach m…

This study looked at how skin blood flow and nerve sensitivity differ in psoriasis plaques compared to healthy skin. Twenty adults with psoriasis on their back received mild electrical currents to deliver vasodilators (acetylcholine, sodium nitroprussiate, or plain water) into bo…

This study looked at 33 adults with ARDS (a serious lung condition) who were lying on their stomachs (prone position) and needed help breathing. Doctors wanted to know if certain heart measurements could tell them when a patient needs more fluids. The study tested different ways …

This study used functional MRI to look at brain activity while people did simple arithmetic. It included 79 healthy right-handed participants: children aged 8 to 14 and adults aged 18 to 24. The goal was to identify which brain regions are involved in math processing, not to test…

This completed study surveyed 55 men who have sex with men who use psychostimulants (like synthetic cathinones) during sex. Researchers used a questionnaire called G-STAT during a regular addiction clinic visit to see if hypersexuality is caused by the drugs or existed before. Th…

This study collected stool samples from 14 patients with bone or joint infections who were receiving long-term antibiotics injected under the skin. The goal was to build a biological sample bank for future research on how gut bacteria develop resistance to antibiotics. No treatme…

This study evaluates the long-term cognitive development of children who were exposed to dexamethasone (a steroid) while in the womb because they were at risk for congenital adrenal hyperplasia (CAH). The goal is to see if the drug causes any thinking or memory problems. Research…

This study looked at a new way to measure airway closure in patients with severe lung injury (ARDS) who are on breathing machines in the ICU. Researchers tested a simple method to see if the lungs are trapping air, which can help doctors adjust ventilator settings. The study invo…

This study tested whether a special type of MRI can detect early changes in the kidneys of people with medullary sponge kidney, a rare condition that can cause kidney stones. Researchers compared MRI scans from 33 adults with the disease to scans from healthy controls. The goal w…

This completed study examined inflammation markers in the fluid from the eyes of 82 people with different stages of age-related macular degeneration (AMD) and a control group without AMD. Researchers collected samples during cataract surgery and tested for 27 inflammation-related…

This study looked at tiny particles that wear off hip implants in 55 adults. Researchers wanted to understand which types of particles cause the most inflammation in the surrounding tissue. The goal is to improve knowledge about why some hip replacements fail sooner than expected…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol and trouble absorbing vitamins. Researchers measured a protective pigment in the eye called macular pigment, which may be low in these patients and could explain why some still develop vis…

This completed study looked at 102 children aged 2 to 8 who were hospitalized for at least 48 hours. Researchers wanted to understand if food pickiness and neophobia (fear of new foods) affect how much children eat in the hospital. They also examined whether a child's family back…

This study looked at 59 adults with Crohn's disease who had surgery to remove diseased parts of their intestine. The goal was to see if certain immune cells in the blood and gut could predict whether the disease would come back within a year. By understanding these patterns, doct…

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to…

This study aims to understand how different parts of the brain send information to each other. Researchers used brain scans and mild electrical stimulation in 157 healthy adults to test a theory about brain waves. The findings may help future research on brain disorders.

This completed study followed 633 stroke or TIA survivors in France to understand why some stop taking their secondary prevention medications. Researchers looked at factors like age, beliefs about medicine, and healthcare access. The goal is to improve long-term adherence and pre…

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This study looked at different ways to estimate the height of children in the pediatric intensive care unit (ICU). Since standard height measurement is often impossible for sick kids, researchers tested methods using a measuring tape and caliper on 477 children. They compared the…

This study looked at whether children with severe infectious shock develop immune suppression, similar to what is seen in adults. Researchers measured immune markers in 105 children admitted to intensive care and compared them to healthy children having surgery. The goal was to u…

This study looked at health-risk behaviors like smoking, alcohol use, diet, and exercise among 46 cancer survivors in France. The goal was to see how common these behaviors are so doctors can better help survivors avoid future health problems. The study found that many survivors …

This study looked at 116 people with advanced neuroendocrine tumors to see if a marker called MGMT can predict which chemotherapy works best. Researchers compared two chemo types—alkylating agents and oxaliplatin—based on MGMT status. The goal is to personalize treatment and impr…

This study used brain scans (fMRI) to see what happens in the brain when healthy people meditate or are hypnotized. 100 volunteers completed tasks and reported their experiences. The goal is to understand how these practices change self-awareness, which could help explain their h…

This study looked at how a non-invasive magnetic brain stimulation technique called rTMS changes brain activity in healthy volunteers and people with long-term nerve pain. Researchers measured brain responses before and after stimulation to see if these changes relate to pain rel…

This study tested a new scale called the SOFMER Activity Scale (SAS) to measure how much help patients in rehabilitation need with physical and mental tasks. Researchers enrolled 152 patients in follow-up care and rehab departments. The goal was to see if the scale is accurate, r…

This completed study examined how a specific serotonin receptor (5-HT4) is expressed in the brains of people with mild to moderate Parkinson's disease compared to healthy older adults. Researchers used PET scans and a special tracer to measure receptor levels, alongside cognitive…

This completed study used non-invasive brain scans (EEG and MEG) to identify electrical signals linked to mental and physical tiredness in 169 healthy adults. Participants performed tasks designed to cause cognitive or physical fatigue while their brain activity was recorded. The…

This study looked at 250 adults having total knee replacement to compare two surgical approaches: resurfacing the kneecap (patella) with a plastic implant versus leaving the natural cartilage in place. The goal was to see which method leads to better knee function and comfort one…

This completed study looked at 165 adults newly diagnosed with lung or head & neck cancer who smoked. Researchers interviewed them by phone about their smoking and drinking habits, and followed up at 3, 6, and 12 months. The goal was to understand what makes it harder or easier f…

This study aims to understand how the brain's wiring changes as people age. Ten healthy volunteers aged 18 to 50 had special MRI scans to map connections between brain regions. The goal is to create a detailed model of the brain's network, called the connectome, which could help …

This study looked at whether tiny molecules in the blood, called microRNAs, can identify epilepsy patients who have dangerous drops in oxygen during seizures. Researchers compared 50 drug-resistant epilepsy patients undergoing video-EEG monitoring, splitting them into those who h…

This study looked at how symptoms of hereditary hemorrhagic telangiectasia (HHT) affect patients' quality of life. Researchers used a special questionnaire developed with patient input to measure different aspects like physical limits, worry about bleeding, and social relationshi…

This study used a technique called transcranial direct current stimulation (tDCS) to apply a mild electrical current to the brain in 37 healthy adults. Researchers used advanced brain scans to measure changes in brain activity, connections, and dopamine levels during and after a …

This completed study looked at how the human brain processes tool use and the ability to make tools better over time. Researchers used fMRI scans on 70 healthy adults while they performed tasks involving tools. The goal was to identify brain areas unique to humans that may explai…

This study looks at how meditation practice influences attention and emotion regulation in healthy adults aged 25 to 70. Researchers use brain scans (MRI, MEG, EEG) and stress biomarkers to understand the changes. The goal is to identify the mechanisms behind meditation's benefit…

This study looked at how healthcare practitioners move their hands and fingers when inserting a peripheral IV catheter. Researchers measured the forces applied to the skin and veins, as well as the angle and speed of the needle. The goal was to gather data to design a more realis…

This study looked at 140 people with recurrent kneecap dislocation who needed surgery. Half received the standard MPFL reconstruction, and the other half had an additional lateral retinaculum release. The goal was to see if the extra release improves kneecap alignment or outcomes…

This study looked at 20 adults in the ICU who were on breathing machines (ventilators) and ready to try breathing on their own. Researchers compared two methods: one using low pressure support and another using automatic tube compensation (ATC) to offset the tube's resistance. Th…

This study tracked immune cell changes in 5 people with advanced melanoma who were taking nivolumab with or without ipilimumab. Researchers took blood and skin samples at several time points to compare immune responses between those who responded to treatment and those who did no…

This study looked at 32 people with advanced melanoma who were treated with the immunotherapy drug Nivolumab. Researchers took blood samples before and during treatment to track changes in immune cells. The goal was to find differences between patients whose tumors shrank or stay…

This study collected PET brain scans from 41 healthy adults aged 20-65 to create a reference database. Doctors can compare these normal scans to those of epilepsy patients to better locate the brain area causing seizures. The goal is to improve surgical planning for patients whos…

This study tested whether taking a daily fiber supplement called chitin-glucan for three weeks could change gut bacteria and improve health markers in 19 adults with abdominal obesity and cardiometabolic risk. Participants took either the fiber or a placebo powder mixed in water.…

This study looks at how sleep helps the brain strengthen motor skills that were learned just by imagining them. Fifty-one healthy adults practiced finger sequences and trackball tasks while their brain activity was recorded with MEG. The goal is to understand which brain networks…

This study looked at how the brain processes faces and voices together when deciding if someone is male or female. Thirty-eight healthy adults had their brains scanned with fMRI while doing a gender classification task. The goal was to understand which brain areas handle visual a…

This study looked at human proteins that stick to hepatitis B virus particles in blood samples from 14 infected adults. The goal was to identify these proteins and understand how they help the virus survive and spread. This is basic research, not a treatment, but it may point tow…

This study looked at 38 adults who had heart surgery to better understand the heart damage that can occur. Researchers used cardiac MRI scans and blood tests for troponin (a heart damage marker) to measure and compare the extent of injury. The goal was to improve knowledge of how…

This study looked at how common human papillomavirus (HPV) infection and abnormal cervical cells are in women with cystic fibrosis (CF). Researchers tested 85 women using Pap smears and HPV DNA tests. The goal was to understand infection rates and how long the virus lasts, so doc…

This study looked at whether the angle of a patient's head (flat at 0° or raised at 30°) changes the esophageal pressure reading used to set ventilators. Eleven adults with acute respiratory distress syndrome (ARDS) had their pressures measured in both positions. The goal was to …

This study looks at how people with congenital amusia (tone deafness) perceive and remember sounds compared to people without it. Researchers used listening tests and brain scans (EEG, MEG, MRI) to understand the differences. The goal is to learn more about the brain areas involv…

This completed Phase 1 study involved 16 healthy men aged 20-35 to test a radioactive tracer called [11C]Yohimbine. Researchers used PET scans to see how the tracer binds to certain brain receptors and measured its effects after giving the drug clonidine. The goal was to understa…

This study looked at 32 adults with severe lung injury (ARDS) who were placed face-down (prone) to help them breathe. Researchers measured pressure inside the lungs using a small balloon in the esophagus. They wanted to see if the face-down position changes lung pressure enough t…

This completed study looked at how a common skin bacterium, Staphylococcus aureus, might cause eczema flares in people with atopic dermatitis. Researchers applied patches containing the bacteria to the skin of 7 participants (both with and without eczema) and measured immune resp…

This completed study followed 281 people who had a severe type of heart attack called STEMI. Researchers collected blood samples, ECGs, MRIs, and quality-of-life questionnaires to find new biological and imaging markers that could help predict outcomes like heart failure. The goa…

This early-phase study tested a new radioactive tracer called [18F]F13640 in 20 healthy volunteers. The tracer is designed to attach to specific receptors in the brain and be seen on a PET scan. The goal was to validate the imaging method and check how reproducible the results ar…

This study looked at 21 people who had a heart attack to see if markers of inflammation in the blood are linked to the amount of heart damage seen on MRI scans. Researchers measured inflammation levels at several time points and compared them to MRI images taken a week later. The…

This study used brain scans (fMRI) to see how children aged 8 to 14 use deductive reasoning—like logical thinking—and how that relates to their math skills. Researchers measured brain activity while kids solved reasoning problems and compared it to their math test scores. The goa…

This completed study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease worse. Researchers compared survival rates between patients infected with PVL-producing bacteria and those without. They also collected blood samples to explore …

This study looked at how head and neck cancer patients sense texture, temperature, and spice in their mouths after treatment. Researchers compared 72 patients to healthy volunteers using touch tests and food preference questionnaires. The goal was to understand if changes in mout…

This study looked for immune tolerance markers in 18 hand and face transplant recipients (transplanted at least one year prior). Researchers analyzed blood and skin biopsies to find a 'tolerance signature' that might identify patients who could safely reduce their lifelong anti-r…

This study used fMRI brain scans to understand how two brain regions—Broca's area and the mid-cingulate cortex—work together to control language. Twenty-three healthy, right-handed adults performed a learning task while their brain activity was measured. The goal is to learn how …

This study measured how fast pulse waves travel from the heart to different arteries in 40 patients undergoing heart surgery with a heart-lung machine. The goal was to see if this speed can detect when blood pressure in central arteries differs from that in arm or leg arteries. R…

This completed study looked at fat tissue in 23 men with advanced chronic kidney disease (stage V) who were not on dialysis. Researchers compared their fat cells to those of healthy men to understand why kidney disease causes problems like weight loss and insulin resistance. Fat …

This study looked at whether the ADHD Rating Scale-IV can detect changes in attention problems in children with epilepsy. Researchers followed 173 children aged 6 to 15 who had both epilepsy and ADHD. They compared scores over 12 to 16 weeks in treated versus untreated children t…

This study tested whether giving a small amount of fluid (3 ml per kg over 2 minutes) can predict if a child needs more fluids during surgery. Researchers measured heart function after the small test and compared it to the standard larger fluid dose. The goal is to help anesthesi…

This study tracked nearly 2,500 adults who came to the emergency room during flu season to see how many actually had the flu. By testing everyone with a nasal swab, researchers aimed to find flu cases that might otherwise go unnoticed. The goal is to give hospitals a clearer pict…

This study tracked 46 people with severe obesity who had gastric bypass or sleeve gastrectomy. Researchers used a special CT scan with gas to measure stomach volume at 3 and 12 months after surgery. The goal was to see if stomach enlargement is linked to weight regain, which coul…

This study looked at whether surgery for vaginal prolapse can be safely done as a day procedure, allowing women to go home the same day. Thirty-eight women with advanced prolapse were treated at three hospitals in Lyon, France. The goal was to see how many could actually be manag…

Fibrous dysplasia is a rare bone disease that causes pain, fractures, and deformities, but its severity varies widely for unknown reasons. This study looked at 24 adults—some with the disease and some without—to see if small molecules called microRNAs in blood and bone tissue are…

This study followed 230 people with cystic fibrosis to understand why some develop diabetes and why it sometimes reverses. Researchers tracked genetics, lung health, infections, diet, and physical activity over a year. The goal is to improve how diabetes is screened and treated i…

This study looked at whether being in labour affects how quickly a light meal (flavoured yoghurt) leaves the stomach. Researchers used ultrasound to measure stomach emptying in 43 women: those in labour with or without epidural, pregnant women not in labour, and non-pregnant wome…

This study looked at how people with brain injuries or migraines process sounds, including attention, memory, and emotions. Researchers used listening tests and brain scans (EEG, MEG, MRI) to measure responses in 262 participants. The goal was to better understand auditory defici…

This pilot study looked at 8 newborns with congenital diaphragmatic hernia (a hole in the diaphragm) after surgery. Researchers compared two types of breathing machines: standard ventilation and a newer method called NAVA, which senses the baby's own breathing signals to provide …

This completed study from a French hospital center surveyed 143 patients who had phalloplasty surgery between 2007 and 2018. Researchers collected data on surgical results, sexual quality of life, and patient satisfaction using questionnaires and medical records. The goal is to b…

This study looked at how well recommended vaccines protect adults who have had a stem cell transplant. Researchers took blood samples from 152 transplant recipients before and after vaccination to measure antibody levels against diseases like tetanus, diphtheria, and hepatitis B.…

This completed study looked at 189 adults who had COVID-19 to see how long their immune system remembers the virus. Researchers collected blood, saliva, and nose swabs at 6 and 12 months after infection to measure antibody levels. The goal was to understand if protective immunity…

This study tested whether a special type of brain scan (PET/MRI) can be used in children aged 5-17 with brain tumors. The scan combines two imaging techniques to give doctors more information about the tumor. Only 15 children took part, and the main goal was to see if the scan wa…

This study looks at how frontal lobe epilepsy changes cooperative behavior and decision-making. Researchers will have 30 patients and 30 healthy volunteers play a classic economic game called the Prisoner's Dilemma while their brain activity is measured with fMRI. The goal is to …

This study looked at 20 people with long-term balance problems caused by inner-ear damage. Researchers wanted to see if fast, unconscious eye movements called 'covert saccades' help them see clearly when moving their head. Participants had their eye movements measured during quic…

This study involved 47 people with drug-resistant epilepsy and healthy volunteers. Researchers recorded brain activity simultaneously using implanted electrodes (intracranial EEG) and non-invasive scans (MEG or fMRI). The goal was to better identify seizure-causing brain areas an…

This study looked at 66 adults with Osteogenesis Imperfecta (brittle bone disease) to see if small molecules called microRNAs in the blood are linked to how severe the condition is. Researchers compared people with mild (type 1) and severe (type 3) forms, plus healthy controls. T…

This study looked at 905 people with uveitis, an eye inflammation, to see if a standardized step-by-step diagnostic plan works as well as letting doctors choose any tests they want. The goal was to find the cause of the uveitis more efficiently and at a lower cost. Researchers co…

This study aims to identify human proteins that stick to hepatitis C virus particles in patient blood samples. By understanding which proteins the virus uses to survive and spread, researchers hope to find new targets for future treatments. Ten adults with chronic hepatitis C eac…

This study looked at how different channels in a cochlear implant interact and affect a person's ability to understand speech in noisy settings. Researchers tested 28 adults—some with normal hearing and some with cochlear implants—using speech tests and sound masking measurements…

This study tested a new method to set breathing machines for 60 children under anesthesia. Instead of using standard formulas, doctors adjusted the machine based on real-time carbon dioxide measurements. The goal was to find the right air volume to keep children breathing safely.…

This completed study looked at whether advanced glycation end products (AGEs) – compounds formed when food is cooked at high heat – affect kidney blood flow and oxygen levels. Ten healthy young men ate either a low-AGE meal (eggs) or a high-AGE meal (mixed nuggets), and their kid…

This study looked at 96 women having their fallopian tubes removed during a hysterectomy for non-cancer reasons. Researchers measured how the surgery affected ovarian reserve (egg supply) using a blood test and ultrasound. They also compared two different surgical tools—one using…

This study looked at whether ultrasound can reliably tell if a person's stomach is full before anesthesia, which helps prevent food or liquid from entering the lungs. Twenty-one healthy adults drank different amounts of water, and researchers compared ultrasound accuracy with the…

This study checked vitamin C levels in 434 patients over 75 admitted to a geriatric unit. Researchers wanted to find out how many had low vitamin C and what factors put them at risk. The goal is to help doctors spot and treat this easily fixable deficiency more often.

This study used MRI to measure how fingertips change shape when pressed or sheared with small forces. Eight healthy adults had their index fingers scanned under different loads. The goal was to collect data to create realistic computer models of human grip, which could help impro…

This pilot study gave 6 healthy women a breakfast containing wheat bran with a special carbon label (13C) to track how it is fermented in the gut. Over 24 hours, researchers collected breath, urine, blood, and stool samples to measure breakdown products. The goal is to identify n…

This study tested whether mentally practicing finger movements (motor imagery) combined with a mild electrical brain stimulation (tDCS) could improve learning of a complex finger sequence in both young (20-35) and older (65-80) healthy adults. 64 participants were split into four…

This study collected blood samples from nearly 1,900 people in families where at least two members have a type of dysglobulinemia, including multiple myeloma, MGUS, or Waldenström's disease. Researchers will analyze the DNA to look for genetic variations that might increase the r…

This study collected umbilical cord blood and tissue from 16 newborns who have a parent with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder causing abnormal blood vessels. Researchers aim to grow and compare endothelial cells from these babies with cells from hea…

This completed study looked at how the SARS-CoV-2 virus spreads within hospitals, involving over 2,000 patients, caregivers, and healthcare workers. Researchers tracked suspected and confirmed cases to identify risk factors and the effectiveness of infection control measures. The…

This completed study looked at whether people with type 2 diabetes who show signs of premature aging (like shortened telomeres) are more likely to develop heart muscle disease. Researchers used heart scans and blood tests in 150 adults aged 40-55 with diabetes but no heart sympto…

This study tested whether a coordinated care pathway, supported by an electronic reporting system shared among patients, doctors, and midwives, improves how well pregnancy care follows recommended guidelines. Over 1,500 pregnant women in France were randomly assigned to either th…

This study followed 1100 adults with severe obesity who took WEGOVY (semaglutide) for 12 months. Researchers collected data on weight, eating habits, and blood markers to see how the drug worked in different groups. The goal is to use this information, along with artificial intel…

This study looks at why people perform differently when others are watching. Using brain scans, researchers measured eye movements and attention in 43 healthy adults while they were observed by a friend or alone. The goal is to uncover the brain mechanism behind social facilitati…

This study aims to create a detailed atlas of the spinal cord's nerve tracts using advanced MRI scans in 49 healthy adults. By combining brain and spinal cord imaging, researchers hope to better distinguish sensory and motor pathways. The goal is to improve diagnosis and surgical…

This study looked at how a 40-minute afternoon nap affects communication between brain regions involved in daydreaming and self-reflection. Fifty-five healthy adults had brain scans before and after napping. Researchers wanted to see if brain connectivity decreases after waking, …

This study looked at 39 people with multiple sclerosis who have chronic vision problems. Researchers used eye exams, scans, and electrical tests to see if the vision loss is caused by nerve scarring (demyelination) or nerve cell death (degeneration). The goal is to better underst…

This completed study looked at how common vitamin C deficiency is among 100 elderly people living in long-term care units. Researchers took a blood sample to measure vitamin C levels and recorded possible risk factors. The goal was to better understand why deficiencies happen in …

This study used fMRI to watch brain activity in 36 healthy adults while they performed eye movement tasks. The goal was to identify which brain regions help adjust eye movements (saccades) to keep them accurate. Participants completed tasks where targets jumped in predictable or …

This completed study tested whether a virtual reality training program could improve the ability to locate sounds in people with hearing loss. 79 participants performed sound localization tasks with and without visual feedback. The goal was to see if training could reduce pointin…

This study looks at why some people with chronic balance problems develop very fast eye movements that help them see clearly when moving their head. Researchers tested 12 patients and 12 healthy volunteers using virtual reality and head movements. The goal was to understand what …

This study looked at how cochlear implant microphones change as they age and get dirty, and whether different signal coding strategies can help. Researchers tested 81 people with hearing loss by having them listen to words in noise at various levels, before and after cleaning the…

This study looked at how music and familiar sounds affect brain activity in people with consciousness disorders after a coma, as well as in healthy volunteers. Researchers measured brain responses (P300 waves) to hearing a person's own name or other sounds. The goal was to unders…

This completed study looked at how the brain adapts eye movements and how that relates to visual perception and attention. Researchers studied 24 people, including healthy adults and those with cerebellar disease. Participants performed specific eye movement tasks while researche…

This completed study in 76 healthy volunteers used brain scans (fMRI) and mild electrical stimulation (GVS) to explore how different types of feedback—like social or monetary cues—influence decision-making. The goal was to map the brain networks involved, with the hope of applyin…

This completed study enrolled over 1,000 vaccinated adults who later tested positive for COVID-19. Researchers analyzed the virus's genetic code and measured antibody levels to understand which variants cause breakthrough infections and how well the immune system responds. The go…

This study tested a new micro-needle for giving TB skin tests, comparing it to the standard method in 59 healthy volunteers. The goal was to see if the new needle makes the test easier to give and more consistent. Researchers also tested a device to read the skin reaction without…

This study looked at how healthy people remember experiences from daily life or virtual reality. Using brain scans (fMRI), researchers measured brain activity during recall to understand which areas are involved. The goal was to learn more about memory and attention, not to test …