PET-Guided strategy may improve outcomes in aggressive lymphoma

NCT ID NCT00498043

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tested two different chemotherapy combinations (R-ACVBP and R-CHOP) along with the targeted drug rituximab in 222 adults aged 18-59 with an aggressive type of B-cell lymphoma. Participants had 2 or 3 risk factors that make the disease harder to treat. The researchers used PET scans after the second and fourth treatment cycles to decide which patients needed more intensive therapy. The goal was to see which combination worked better and whether a PET-guided approach could improve complete response rates.

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Contacts and locations

Locations

  • René Olivier Casasnovas

    Dijon, 21000, France

Conditions

Explore the condition pages connected to this study.